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자궁내막증 치료에 있어서 GnRH agonist (Nafarelin Acetate) 의 효용성
목정은,이주학,고준성,남주현,정동근,전대준 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10
자궁내막증 치료에 있어 GnRH agonist의 효용성을 알아보기 위하여 15명의 자궁내막증 환자를 대상으로 하여 nafarelin을 6개월간 비강내 분무투여 하여 다음과 같은 결과를 얻었다. 1. 혈중 E₂농도는 치료기간중에 유의한 감소를 보였으며, 혈중 CA-125농도도 치료시작전에 비해 치료시작후 의미있는 감소를 보였다. 2. 15명의 환자 모두에서 치료후 endometriosis score의 유의한 감소가 있었다. 3. 15명의 환자 모두에서 치료전의 증상이 치료기간 중에 증상의 소실 또는 호전을 보였다. 4. 부작용으로는 안면홍조, 질 건조감, 두통, 성교통, 유방크기의 감소, 불면증, 성욕감퇴, 근육통, 관절통, 체중증가, 우울증 등이 있었으나, 부작용으로 치료를 중단한 에는 없었다. 이상의 결과로 볼때 자궁내막증 환자에 있어 GnRH agonist(nafarelin)의 투여는 효과적이며 안전한 치료방법으로 사료된다. To evaluate the efficacy and safety of nafarelin for the treatment of endometriosis, twenty women with laparoscopically proven endometriosis were recruited to the study. The patient were treated with intranasal nafarelin, 400 micro g/day(100 micro twice a day) for 6 months. Efficacy assessments were based on preadmission and end-of treatment laparoscopic scores and subjective symptom scores at admission and end-of treatment. Safety was evaluated by adverse events. We observed following results. 1. Serum estradiol levels and serum CA-125 levels significantly fell during the treatment. 2. The endometriosis scores significantly decreased after treatment. 3. Symptoms of endometriosis significantly improved during treatment. 4. There was none of patients interrupted during treatment due to adverse effects. These data suggest that intranasal GnRH agonist, nafarelin is a effective and convenient approach to the medical treatment of endometriosis.
분자간의 상호간섭을 고려한 2성분계 흡착의 확률적 모델링
이승목,이주광 ( Seung Mok Lee,Ju Goang Lee ) 한국물환경학회 1996 한국물환경학회지 Vol.12 No.2
A Markov process coupled with interaction between molecules is developed to simulate bisolute adsorption kinetics. This model is relatively simple in that estimates of all model parameters except interaction parameters are obtained from single solute experiment. Transient behavior of molecules can be evaluated by analytically solving a system of the governing ordinary differential equations of the present stochastic model. Adsorption rate profile is not affected by interaction parameters at low concentration range.
강릉시 식수계중 휘발성 유기화합물질 ( VOCs ) 의 분포
이주광,이승목,윤이용 ( Ju Goang Lee,Seung Mok Lee,Yi Yong Yoon ) 한국물환경학회 1996 한국물환경학회지 Vol.12 No.3
A survey of Volatile Organic Compounds(VOCs) was conducted in the Kangnung City raw water, treated water and groundwater from Mar. 1994 to Dec. 1994. Four VOCs. 1,1,1- trichloroethane, carbon tetrachloride, trichloroethylene and tetrachloroethylene, were detected below detection limit level. Among those, 1,1,1-trichloroethane, carbon tetrachloride and trichloroethylene were detected at trace and frequently. Trichloroethylene was contaminated in the highest level among detected four VOCs. The mean concentrations of trichloroethylene were 1.15㎍/ℓ of the raw water, 3.30㎍/ℓ of the treated water and 0.47㎍/ℓ of the groundwater. respectively. The concentration levels of the VOCs from the raw water and the treated water were increased from winter to summer, while this trend cannot be found in groundwater.
남주현,목정은,한지수,이주학,전대준 대한부인종양 콜포스코피학회 1993 Journal of Gynecologic Oncology Vol.4 No.3
Mucocele of the appendix is uncommon and rarely diagnosed preoperatively. The malignant countpart-i. e. mucinous cystadenocarcinoma--has the same gross appearance and many micro scopic features in common with the benign form. It may be associated with ovarian mucinous cystadenoma of strikingly similar microscopic appearance. A serious complication is a rupture of the mucocele resulting in pseudomyxoma peritonei. Each case of benign and malignant mucocele of the appendix falsely diagnosed as an ovarian tumor before laparotomy are presented with a brief review of the literatures.