재발성군날개 치료에 있어 항혈관내피성장인자 항체 베바시주맙을 적용한 임상효과

이종욱,박영정,김인택,이규원,Jong Wook Lee,Young Jeung Park,In Taek Kim,Kyoo Won Lee 대한안과학회 2008 대한안과학회지 Vol.49 No.12

Purpose: To clinically establish the effectiveness and safety of bevacizumab on recurrent pterygium. Methods: Twenty patients with recurrent pterygium were given a subconjunctival injection of 0.3 cc bevacizumab, and were evaluated for periodic clinical results at 1 week, 2 weeks, 4 weeks, and every month thereafter. The patients were also evaluated for clinical results and complications. Results: Of recurrent pterygium patients with bevacizumab injection, the conjunctival injection decreased maximally after 1 to 2 weeks, but significantly increased at 4 weeks (above the lowest level measured at 1 to 2 weeks), and no patient presented conjunctival injection above the pre-injection level at 3 months, except in 2 cases. Two weeks after the injection, ICG anterior segment angiography revealed a significant decrease (30.14+17.69%) in vessel thickness of the pterygium 2 weeks after the bevacizumab injection compared to before the injection. There had been no cases of progression of pterygium, and no ocular or systemic complications due to bevacizumab. Conclusions: As shown above in the results, subconjunctival injection of 0.3 cc bevacizumab decreased the conjunctival injection and effectively suppressed any further progression of pterygium. Thus, bevacizumab subconjunctival injection appears to be effective in recurrent pterygium treatment instead of surgical methods.

소안구증 환자에서 piggyback 방법을 이용한 백내장 수술

이종욱,최원석,박영정,이규원.Jong Wook Lee. MD. Won Suk Choi. MD. Young Jeung Park. MD. PhD. Kyoo Won Lee. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.7

Purpose: To report a case of cataract surgery using a piggyback method in a patient with pure nanophthalmos with an axial length under 16.00 mm in both eyes. Case summary: The authors performed cataract surgery using a piggyback method inserting two intraocular lenses (IOLs) in a 44-year-old male with nanophthalmos with axial lengths of OD 15.36 mm, and OS 15.59 mm. Primary implantation of two IOLs of +53.0D as calculated by the SRK/T and Holladay formula was performed in the right eye using a piggyback method. In the left eye, two IOLs of +60.0D calculated by the Hoffer Q formula were implanted. Postoperative hyperopic refractive errors occurred in both eyes. The differences between the preoperative target spherical equivalent (SE) and the postoperative one year four month SE were 9.68D in the right eye and 1.63D in the left eye. Conclusions: Due to high diopter IOL requirements in nanophthalmic patients (less than 16.00 mm) during cataract surgery, the refractive errors were well corrected, without complications, by using a piggyback method. In the present case study, the Hoffer Q formula produced better results than did the SRK/T or Holladay formula in reducing the difference in preoperative and postoperative SEs, but more surgical cases and research are required to establish the most appropriate formula for cataract surgery in nanophthalmos.

Co계 자성합금 나노와이어의 특성에 영향을 미치는 전기화학적 변수

이종욱,박호동,이관희,김긍호,정원용,Lee, Jong-Wook,Park, Ho-Dong,Lee, Kwan-Hyi,Kim, Gyeung-Ho,Jeung, Won-Young 한국전기화학회 2005 한국전기화학회지 Vol.8 No.3

본 연구에서는 고순도 알루미늄 호일$(t=300{\mu}m)$양극산화 공정을 통해 AAO 나노템플레이트를 자체 제조하였고, 이렇게 제조된 형틀을 가지고 교류 나노전주법에 의해 경자성 합금인 CoP와 연자성 합금인 CoFe를 나노와이어로 제조하였다. 대표적인 Co계 자성합금인 CoP와 CoFe나노와이어는 각기 독특한 자기적 성질을 나타내었다. 경자성 CoP 합금 나노와이어의 경우 교류 인가전압에 따라 hcp와 fcc가 혼재된 구조가 형성되어 자기적 특성에 영향을 미쳤다. 또한 높은 포화자화 값을 갖는 CoFe연자성 합금 나노와이어는 박막 도금 시와는 달리 이상합금도금현상이 거의 나타나지 않았으며 $Co_{30}Fe_{70}$에서 가장 좋은 238emu/g의 포화자화 값을 나타내었다. We have investigated the electrochemical factors affecting the magnetic properties of hard magnetic CoP nanowires and soft magnetic CoFe nanowires fabricated by ac electrodeposition into self-made AAO(anodic aluminum oxide) nano-templates. AAO template having nano scale pores of high aspect ratio has been prepared through 2-step anodizing of aluminum foil in sulfuric acid. Hard Magnetic properties of CoP nanowires were highly conditional on the applied ac potential which could be a decisive factor to make CoP nanowires made up of either pure hcp crystals or a mixture of hop crystals and fcc crystals. On the contrary to CoFe films, there was no anomalous codeposition in the electrodeposition of soft magnetic CoFe nanowires which exhibited their best saturation magnetization of 238 emu/g at the composition of $Co_{30}Fe_{70}$.

III-V족 화합물 반도체 InSb 나노와이어의 전기화학적 합성 및 특성 평가

이관희,이종욱,박호동,정원용,이종엽,Lee, Kwan-Hyi,Lee, Jong-Wook,Park, Ho-Dong,Jeung, Won-Young,Lee, Jong-Yup 한국전기화학회 2005 한국전기화학회지 Vol.8 No.3

본 연구에서는 그동안 전기화학적으로 합성되지 못했던 III-V족 화합물 반도체 InSb를 구연산 용액으로부터 합성하였으며 자체 제조한 AAO를 나노템플릿으로 이용하여 정전압 도금을 실시하여 InSb 나노와이어를 제조하였다 제조된 InSb나노와이어는 X선 회절분석 결과 단결정의 나노와이어는 아니었으나 정확하게 화학양론을 만족시키는 화합물임을 확인하였고, 평판 박막 상태의 InSb와는 달리 나노와이어의 길이방향으로 (220) 방향의 결정이 주로 성장하는 우선결정방위를 가지고 있음을 알 수 있었다. 또한 집합적으로 배열된 상태에서 측정된 I-V특성 곡선에서는 n형 반도체의 특성을 보이되 밴드갭이 좁고, 전자이동도가 큰 InSb고유의 특성상 반금속과 유사한 전기적 특성을 보유하고 있음을 확인하였다. To the best knowledge, the formation and characterization of InSb nanowires have not been reported yet in spite of its good characteristics as a III-V compound semiconductor. The nanowire arrays were potentiostatically electrodeposited in a mixing solution of indium chloride, antimony chloride, citric acid, and potassium citrate according to our previous work on the electrodeposition of the stoichiometric InSb films. The electrical properties of nanowire arrays were measured by semiconductor parameter analyzer, and the microstructural analysis of the nanowires was conducted by employing XRD. Our experimental results indicate that the InSb nanowires have a highly preferred orientation of (220) direction and also exhibit electrical characteristics of n-type semiconductors which we, however, similar to semi-metals mainly due to their narrow band-gap and high electron mobility.

III-V 화합물 반도체 InSb의 전기화학적 제조

이정오,이종욱,이관희,정원용,이종엽,Lee, Jeong-Oh,Lee, Jong-Wook,Lee, Kwan-Hyi,Jeung, Won-Young,Lee, Jong-Yup 한국전기화학회 2005 한국전기화학회지 Vol.8 No.3

본 연구에서는 구연산 수용액 전해질을 제조하여 전기도금 방식에 의해 III-V족 화합물 반도체 InSb를 전기화학적으로 합성하였다. 본 연구에서 제조된 InSb는 기존문헌에서 보고된 바와 달리 EPMA분석결과 In과 Sb의 조성비가 52:48로 화학양론을 정확하게 만족시키고 있고, XPS분석결과 전해질내의 구연산의 농도가 1.2M, pH가 4일 때 444.1 eV에서 InSb 화합물의 피크를 관찰하였으며 구연산의 농도가 1.2M보다 낮거나 pH가 4보다 낮을 때는 InSb화합물과 금속상태의 In이 혼재되어 있는 것을 확인하였다. 또한 XRD를 통하여 InSb(111)의 우선결정방위를 갖는다는 것을 확인하였고, I-V 특성 곡선 측정을 통해 rnSb가 고유한 반도체 특성을 보임을 확인하였다. We investigated the electrochemical formation of a stoichiometric III-V compound semiconductor of InSb from an aqueous citric solution. Under an? optimized electrochemical condition, not like other research results, the electrodeposited InSb are satisfied exactly with the stoichiometry. Furthermore it retains the inherent characteristics of III-V compound semiconductor, InSb without heat treatment. EPMA, XPS and XRD were employed for confirmation of its composition/stoichiometry, chemical state, and crystallographic orientation, respectively.

Phentermine Hydrochloride에 의한 급성 근시와 전방각 폐쇄 1예

구성현,최원석,이종욱,박영정,이규원,Sung Hyun Koo,Won Suk Choi,Jong Wook Lee,Young Jeung Park,Kyoo Won Lee 대한안과학회 2011 대한안과학회지 Vol.52 No.7

Purpose: To describe a case of bilateral acute myopia and acute angle-closure associated with phentermine hydrochloride, a drug used for obesity treatment. Case summary: A 25-year-old woman visited our hospital with blurry vision and ocular pain after taking phentermine hydrochloride for three weeks. Manifest refraction accompanied myopic shift in the both eyes, slit-lamp examination showed forward displacement of the lens-iris diaphragm and fundus examination revealed retinal folds. Suspecting phentermine hydrochloride induced acute myopia and acute angle closure, discontinuation of the drug and administration of cycloplegic agents and antiglaucomatic agent successfully resolved the symptoms. Conclusions: Although the exact mechanism is unknown, phentermine hydrochloride may generate ciliochoroidal effusion and ciliary edema, lead to acute myopia and acute angle closure resulting from forward displacement of the lens-iris diaphragm. J Korean Ophthalmol Soc 2011;52(7):881-886

거제도 인근도서(지심도, 내도, 윤돌도)의 자원식물상 연구

박선주(Seon-Joo Park),우복주(Bok-ju Woo),박성준(Seong-Jun Park),황규진(Gyu-Jin Hwang),김금숙(Kum-Suk Kim),이종욱(Jeung-Wook Lee) 한국자원식물학회 2005 한국자원식물학회지 Vol.18 No.3

거제도의 인근도서 지심도, 내도, 윤돌도 식물상 조사는 2004년 3월, 6월, 8월 총 3번에 걸쳐 식물상을 조사하였다. 본 조사 결과 관속식물은 지심도 64과 114속 121종 10변종 131분류군, 내도 53과 79속 5변종 81분류군, 윤돌도 14과 15속 15종 1변종 16분류군으로 총 72과 140속 149종 14변종 1품종 164분류군이 동정하였다. 멸종위기식물은 관찰되지 않았으나, 한국특산식물은 거제딸기, 섬쥐똥나무 등 2과 2속 1종 1변종 총 2분류군이 확인되었다. 식물구계학적 특정식물은 가는쇠고사리, 섬쥐똥나무, 나도생강, 털머위, 생달나무, 센달나무, 남오미자, 멀꿀, 팔손이 등을 포함 25과 33속 36종 2변종 38분류군이 관찰되었다. 그 외에 귀화식물은 소리쟁이, 자리공, 토끼풀, 까마중, 선개불알풀, 주홍서나물, 개망초, 별꽃아재비등 6과 10속 10종으로 우리나라 전체 귀화식물종 284종에 대한 도시화지수(U.I) 및 귀화율은 3.52%와 6.1%이다. 조사지역은 장승포와 옥포 등 가까운 거리에 있고 자연경관이 뛰어나 방문객의 수가 갈수록 급증할 것으로 예상되어 귀화식물의 종류와 수는 앞으로 더욱더 늘어날 것으로 전망된다. 또한 낚시터로 많은 사람들의 출입이 빈번한 곳이다. 이에 따른 식생이 파괴될 위험이 크므로 조사지역의 상록활엽수림에 대한 보존대책이 요망된다. The floras of Jisimdo, Naedo and Yundoldo around Koje Island were investigated 3 times from January 2004 to November 2004. The vascular plants recorded were 165 taxa, 1 forms, 15 varieties, 149 species, 140 genera, 72 families, The rare and endangered plants were recorded as 1 taxa (Quercus gilva Blume), Korean endemic plants were recorded as 2 taxa (1 variety, 1 species, 2 genera, 2 families). The naturalized plants were 10 taxa, 10 species, 10 genera, 6 families, 3.52% and 6.1% among the total naturalized plants and Urbanization Index in Korea. Anglers and visiter s number is expected to increase fast because nature of Jisimdo, Naedo and Yundoldo, in which kind and number of naturalized plants are forecasted to be increased more.