요통환자에 관한 임상적 연구

전제균 대한물리치료학회 1992 대한물리치료학회지 Vol.4 No.1

This study was carried out by using questionnaires with 230 lumbago patients who visited the general hospitals, orthopedic clinics, neurosurgery clinics and physical treatment centers in Taequ, Korea for one month from December 20, 1991 to January 20, 1992. The result of this study is summarized as follows. 1. 203 patients consisted of 113 males and 9t) females, while 65 patients were 30s which was the highest percentage. 2. The relation between their occupational properties and lumbago indicated that there was significant relation m their total employed period, job hours, monthly average incomes(P$lt;0.01), job satisfaction. working posture, mental stress(P$lt;0.01), excessive usage of back during working, lifting of heavy thing and serious noises. 3. The relation between social properties and lunbago showed that there was a remarkable relation in their introspective character(P$lt;0.05), daily average riding hour(P$lt;0.05), smoking(P$lt;0.01), drinking(P$lt;0.01) and insufficient physical exercise. 4. The relation between the clinical properties and lumbago indicated that the lumbago was mainly caused by lifting the heavy thing, which was continued for three months or longer. And, it was shown that they consider the lumbago as one of serious diseases. In addition. they positively evaluated their physical treatment. Therefore, it is required to accomplish the comprehensive treatment of this lumbago on the basis of the educational contents centering around its prevention by performing more suitable health education.

다수 유전자 프로그램의 최적 결합을 위한 확률적 탐색 방법

정제균(Je-Gun Joung),장병탁(Byoung-Tak Zkang) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.1B

유전자 프로그래밍은 고정적인 구조가 아닌 가변 길이의 트리 구조를 가지고 있어서 여러 세대를 통하여 다양한 개체들을 만들어 낸다. 이러한 특징은 위원회 머신(committee machines)을 구축하는데 있어서 자연스럽고 또한 효과적인 알고리즘일 수 있다. 하지만 해결해야할 요소 중 하나는 다수의 개체들에서 결합할 개체의 선택과 개체의수를 결정하기 위한 방법이다. 본 논문에서는 효과적인 개체들의 결합이 되기 위한 새로운 탐색방법을 소개한다. 이 방법은 확률적인 진화 탐색을 바탕으로 하고 있다. 제안된 방법을 여러 가지 분류 문제에 적용하였으며 실험을 통하여 탐색의 특성과 일반화 성능을 분석하였다.

심폐바이패스 없는 관상동맥우회술의 임상성적

신제균,김정원,정종필,박창률,박순은 대한흉부외과학회 2008 Journal of Chest Surgery (J Chest Surg) Vol.41 No.1

Background: Off-pump coronary artery bypass grafting (OPCAB) shows fewer side effects than cardiopulmonary bypass, and other benefits include myocardial protection, pulmonary and renal protection, coagulation, inflammation, and cognitive function. We analyzed the clinical results of our cases of OPCAB. Material and Method: From May 1999 to August 2007, OPCAB was performed in 100 patients out of a total of 310 coronary artery bypass surgeries. There were 63 males and 37 females, from 29 to 82 years old, with a mean age of 62±10 years. The preoperative diagnoses were unstable angina in 77 cases, stable angina in 16, and acute myocardial infarction in 7. The associated diseases were hypertension in 48 cases, diabetes in 42, chronic renal failure in 10, carotid artery disease in 6, and chronic obstructive pulmonary disease in 5. The preoperative cardiac ejection fraction ranged from 26% to 74% (mean 56.7±11.6%). Preoperative angiograms showed three-vessel disease in 47 cases, two-vessel disease in 25, one-vessel disease in 24, and left main disease in 23. The internal thoracic artery was harvested by the pedicled technique through a median sternotomy in 97 cases. The radial artery and greater saphenous vein were harvested in 70 and 45 cases, respectively (endoscopic harvest in 53 and 41 cases, respectively). Result: The mean number of grafts was 2.7±1.2 per patient, with grafts sourced from the unilateral internal thoracic artery in 95 (95%) cases, the radial artery in 62, the greater saphenous vein in 39, and the bilateral internal thoracic artery in 2. Sequential anastomoses were performed in 46 cases. The anastomosed vessels were the left anterior descending artery in 97 cases, the obtuse marginal branch in 63, the diagonal branch in 53, the right coronary artery in 30, the intermediate branch in 11, the posterior descending artery in 9 and the posterior lateral branch in 3. The conversion to cardiopulmonary bypass occurred in 4 cases. Graft patency was checked before discharge by coronary angiography or multi-slice coronary CT angiography in 72 cases, with a patency rate of 92.9% (184/198). There was one case of mortality due to sepsis. Postoperative arrhythmias or myocardial infarctions were not observed. Postoperative complications were a cerebral stroke in 1 case and wound infection in 1. The mean time of respirator care was 20±35 hours and the mean duration of stay in the intensive care unit was 68±47 hours. The mean amounts of blood transfusion were 4.0±2.6 packs/patient. Conclusion: We found good clinical outcomes after OPCAB, and suggest that OPCAB could be used to expand the use of coronary artery bypass grafting.

Marfan 증후군 환자에서 개심수술 및 누두흉의 교정

신제균,정종필,이용직 대한흉부외과학회 2002 Journal of Chest Surgery (J Chest Surg) Vol.35 No.7

Marfan 증후군에 심한 누두흉이 동반된 경우 정중흉골절개시 개흉기를 걸기도 힘들고 대혈관과 심장의 노출이 어려울 수 있다. 저자들은 대동맥근확장의 직경이 52 mm, 중등도의 대동맥판 폐쇄부전증, 고도의 승모판 폐쇄증, 누두흉을 가진 33세의 남자환자에서 대동맥근부의 근치술과 승모판 치환술을 시행하면서 누두흉을 성공적으로 치유했기에 보고한다. 정중절개에 의해 심장 및 대동맥에 접근했고 개심술 후 프로타민 투여 직후 시행된 변형된 늑연골의 절제와 흉골거상으로 수술후 안정된 흉벽을 형성할 수 있었다. Combined Repair of Pectus Excavatum and Open Heart Surgery in Marfan's Syndrome

완전 흉골열 - 1례 보고 -

신제균 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.10

Congenital defects of the sternum are rare development anomalies. They result form the failure of the lateral sternal bars to fuse. This malformation may be associated with other ventral midline fusion defects and ectopia cordis. A complete sternal cleft is the rarest form and less than 10 cases have been reported in the medical literature. Here were report a 3-day-old boy with complete sternal cleft without other malformations, who underwent primary surgical repair. Surgical correction of complete sternal cleft should be performed in neonatal period whether the infant if symptomatic or not because it is usually simple, able to achieve good result and primary repair is usually feasible at this period.

기관에 발생한 소세포암 - 1례 보고 -

신제균,정종필,류상완,서재희,박재후 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.8

59세 여자환자에서 매우 드문 기관의 소세포암을 치험하였기에 보고한다. 진단은 병리조직학적 소견 및 면역조직화학적 검사로 확진하였고, 외과적 절제후 보조적 항암요법을 한 뒤 호전이 있었으나 술후 6개월째 다발성 전이를 보이면서 사망하였다. A rare small cell carcinoma of the trachea was managed in a 59 year old female patient. The diagnosis was confirmed by histopathological and immunohistochemical studies. Surgical resection and adjuvant chemotherapy were done. The patient died 6 months later due to multiple metastasis.

특발성 유미흉 치험 1례 보고

신제균,정종필 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.6

A 51-year-old woman was transferred from a private hospital for persistent massive left pleural effusion. Available examination methods did not reveal the cause of the disease. The pleural effusion was confirmed as chylothorax by thoracentesis and chest computed tomography. Previous tube drainage and pleurodesis had failed. Therefore we decided on an operative approach. A left thoracotomy revealed nothing abnormal except for the oozing lymph from the mediastinal pleura, which was sutured by 4-0 prolene. Decortication and pleurodesis were done at the same time. Postoperative course was uneventful and no recurrent pleural effusion was recognized for 3 months. Adult Idiopathic unilateral chylothorax with unknown etiology is rare, but this case was successfully treated with an operative method. 유미흉은 보전적인 치료로는 비교적 실패할 확률이 높고 여러 가지 합병증을 동반할 수 있어 적극적인 수술적 치료를 고려하여야 한다. 환자는 51세된 여자로 지속되는 좌측의 흉수로 타병원에서 전원 되었다. 가능한 여러 가지 검사와 문진에서도 흉수의 원인은 알 수 없었고, 흉수천차로 유미흉은 확진할 수 있었다. 이전 병원에서 흉관을 통한 배액과 흉막 유착술을 시행한 보전적 치료가 실패하였으므로 적극적으로 수술적 치료를 시행하였다. 수술 소견상 종격동 흉막에서 국소적 누출을 발견하여 봉합하였으며, 동시에 흉막 박피술과 흉막 유착술을 시행하였다. 술후 경과는 순조로왔으며, 3개월 동안 흉수가 재발하지 않았다. 성인에서 일측성으로 나타나는 유미흉은 매우 드물며 성공적으로 수술적 치료를 하였다.

전립선암 종양 이질성 규명을 위한 차세대 염기서열 분석의 유용성

정제균(Je-Gun Joung),박주영(Joo-Young Park),양소윤(So-Yun Yang),정정윤(Jeongyun Jeong) 대한비뇨기종양학회 2021 대한비뇨기종양학회지 Vol.19 No.2

Prostate cancer has long been considered a disease with a heterogeneous phenotype. The intratumor heterogeneity (ITH) may affect diverse phenotypes such as treatment response, drug resistance, and overall clinical outcomes. Despite technical advances over the past decade, we have an incomplete understanding of the extent and effects of ITH in prostate cancer progression. We present here a comprehensive review of the various studies dealing with ITH in prostate cancer. We discuss the advanced next-generation sequencing analyses including single cell sequencing and circulating cell-free DNA sequencing that have the impact of heterogeneity on clinical decision making.

인공심장판막의 재치환술 5례 보고

신제균 대한흉부심장혈관외과학회 1985 Journal of Chest Surgery (J Chest Surg) Vol.18 No.4

From January 1985 to July 1985, prosthetic heart valves were replaced in 5 patients at Keimyung University Dongsan Medical Center. The patients included three women and two men ranging in age from 22 to 41 years. Three mitral valve replacements, one aortic valve replacement and one double valve replacement [mitral and aortic valve replacement] were done at the first valve operations. Reoperation were performed 2 to 76 months after the first operations, Prosthetic valve endocarditis occurred in 3 patients, early in one and late in two and primary valve failure occurred in 2 patients. In operative findings, vegetation in prosthetic valve endocarditis and calcification in primary valve failure were found. All except one had relatively successful operative results. One died of early fungal prosthetic valve endocarditis due to relapsed prosthetic valve endocarditis with heart failure and block.

선천성 교정형 대혈관 전위증치험 2례 보고

신제균 대한흉부심장혈관외과학회 1985 Journal of Chest Surgery (J Chest Surg) Vol.18 No.4

Congenitally corrected transposition of great arteries is a rare congenital heart anomaly. We experienced two case of corrected transposition of great arteries, one [S,L,L] and one [I, D,D] associated with patent foramen ovale, ventricular septal defect and pulmonary stenosis. The patent foramen ovales were closed directly under right atriotomy, the ventricular septal defects were closed with Dacron patch under morphological left ventriculotomy and the pulmonary valvular and subvalvular stenosis were corrected under pulmonary arteriotomy. The postoperatively course was uneventful in case I, the permanent pacemaker was implanted in case ll.