신경근전기자극에 의한 척수운동신경원의 흥분성 변화

이정우,김태열,이인학,이준희,Lee, Jeong-Woo,Kim, Tae-Youl,Lee, In-Hak,Lee, Joon-Hee 대한임상전기생리학회 2003 대한임상전기생리학회지 Vol.1 No.1

The purpose of this study was to determine the effect of neuromuscular electrical stimulation(NMES) on the alteration of spinal motor neuron excitability. In this article, I would like to experiment on a standard capacity of clinical electrophysiology, a difference in applying methods and a clinical efficiency of NMES by Nerve conduction velocity. We used normal eight subjects without neuromuscular disease and all subjects participated 3 session, which at least 1 week between session. Participants classified according to each group in Antagonist, Agonist, Antagonist-Agonist by the NMES. The test was measured continuously pre test, post-test, post 20 minute test by EMG including H reflex, F wave, motor nerve conduction velocity(MNCV). The following results were obtained; 1. H-reflex latencies and H/M intervals were significantly increased in agonist and antagonist-agonist group(p<.01). 2. H-reflex amplitudes and H/M ratios were significantly decreased in agonist and antagonist-agonist group(p<.01). In agonist group, H-reflex amplitudes and H/M ratios were more significantly decreased than antagonist group. 3. F-wave latencies were significantly increased in agonist and antagonist-agonist group(p<.01). F/M intervals were significantly increased in antagonist-agonist group(p<.01). F wave conduction velocities were significantly increased in agonist and antagonist-agonist group(p<.01) but F/M ratios were not significant. 4. MNCV were significantly decreased in agonist(p<.01). These results lead us to the conclusion that agonist and Antagonist-agonist was significantly decreased excitability of spinal motor neuron. Conversely, Antagonist does not decreased. Therefore, A further direction of this study will be to provide more evidence that NMES have an effect on excitability of spinal motor neurons in UMN syndrome.

논문편 : 신세대 기혼남녀의 라이프스타일 , 가정경영의식 및 행동

이정우,김명자,계선자,박미석,지금수,김경숙,이정숙,박미금 ( Jeong Woo Lee,Myung Cha Kim,Sun Ja Kye,Mee Sok Park,Keum Soo Chi,Kyung Sook Kim,Jung Sook Lee,Mi Kum Park ) 대한가정학회 1997 Human Ecology Research(HER) Vol.35 No.1

확장된 쐐기조사야에 의한 조직산란계수의 변화

이정우,조화섭,박성렬,Lee, Jeong-Woo,Cho, Hwa-Seop,Park, Seong-Ryul 대한방사선치료학회 1998 大韓放射線治療技術學會誌 Vol.10 No.1

In recent days, although many kinds of beam modifiers are developing and using for clinical purposes in accordance with progressing medical engineering, physical wedges are preferred to use as a beam modifier by a lot of institutions until now because of cost, complexities of dosimetry and mechanical uncertainties. According to progressing technology, available field size of wedge is more enlarger than that of old model LINAC. Because field size dependence of wedged fields increases in new model LINAC, we was trying to know that how much different PSFs are in enlarged wedged fields compared with open fields. In small or middle size of fields($4{\times}4{\sim}15{\times}15cm$), there are only a few percents of PSF variation between open and wedged fields. But there are $2{\sim}8\%\;variations\;in\;relatively\;large\;fields(20{\times}20{\sim}30{\times}40cm)$.

신경근전기자극에 의한 H 반사의 변화

이정우,김태열,Lee, Jeong-Woo,Kim, Tae-Youl 대한물리치료과학회 2003 대한물리치료과학회지 Vol.10 No.1

The purpose of this study was to determine whether neuromuscular electrical stimulation(NMES), applied over the antagonist or the agonist, would alter the H reflex. Attention was focused on the roles of stimulus location. We used normal eight subjects without neuromuscular disease which were divided into 3 groups; the subjects were diveded into group of antagonist, agonist, antagonist-agonist. All groups were meted of eight subjects. Neuromuscular electrical stimulation was administered for 15 minutes. All subjects were subjected to three tests, including a pre-test, post-test and post-20 minute test. The data were analyzed by repeated measures ANOVA and paired t-test. The results were as follows; 1. H latencies were significantly increased in agonist and antagonist-agonist group (p<.01). 2. H/M intervals were significantly increased in agonist and antagonist-agonist group (p<.01). 3. H amplitudes were significantly increased in agonist (p<.001) and antagonist-agonist group (p<.01). 4. H/M ratios were significantly decreased in agonist and antagonist-agonist group (p<.01). In agonist group. H-reflex amplitudes and H/M ratios were more significantly decreased than antagonist group. Future studies will need to determine what influence NMES may have on the excitability of spinal motor neurons in people having UMN syndrome.

경표피수분손실 및 Methyl Nicotinate 경피흡수에 의한 혈관 반응 측정을 이용한 피부 장벽 기능 검사

이정우,김도원,전재복,정상립 ( Jeong Woo Lee,Jae Bok Jun,Do Won Kim,Sang Lip Chung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

Background: The measurement of transepidermal water loss(TEWL) is widely used in evaluating the stratum corneum barrier function. It is also possible to evaluate the penetration of substances into the skin as an adc'itional parameter of the straturn corneum barrier function. Objective : The purpose of the present study is to investigate ihe relat,ionship between TEWL and t,he percutaneous absorptic n of met,hyl nicotinate(MN) in the normal and acute perturbative state of the epidermal barrier. Method: Vascular response 10 MN penetration were rneasured by both laser Doppler flowmetry (LDF) and visual erythema oii the forearms of 30 healthy volunteers. Stratum corneum of the ar ea of 2*10cm on the volar for earm was removed by repeated tape stripping when TEWL reached 12-30g/rnh measured with Evaporimeter. The left forearm received no treatrnent as a control site. Each time the profile of the vascular response to MN penetration was analysed using the following parameters.the 1; g time between MN application and initial response(T0), the time between MN application and maximal response(Tmax), and the rnaximal response(LDF), the time between MN application and initial visual erythema(VT0), and the time between MN application and maxirnum visual erythema(VTmax). Results : The data showed a negative correlation between TEWL and T0(r=-12.89, p<0.001), TEWL and Tmax=(r=-14.87, p< 0.001), and TEWL and VT0>(r= -3.99, p<0.001), TEWL and VTmax(r = -9.29, p<0.001). And there was a positive correlation between VT0 and T0(r=1.19, p<0.001), and between VTmax and Tmax(r=1.05, p<0.001). However, there was no detectable correlation between TEWL and LDFmax(p>0.05). Conclusion : Vascular response to percutaneous absorption of MN measured by LDF as well as TEWL is a useful non-invasiv method for objective evaluation of the stratum corneum barrier function. In addition, visual erit,hema induced by t,opical vasodilators such as MN is also a good method for skin barrier function assessment. (Korean J Dermatol 1997;35(6): 1121 1129)

정상 여성에게서 앞 정강근의 수축훈련방법에 따른 뇌파의 변화

이정우,김문정,윤세원,Lee, Jeong-Woo,Kim, Moon-Jeong,Yoon, Se-Won 대한물리치료학회 2012 대한물리치료학회지 Vol.24 No.2

Purpose: This study aims to examine the power changes in eletrocenphalogram (EEG) detected from the tibialis anterior muscle, during repetitive contraction exercise in normal female adults. Methods: The subjects of this study were 24 normal adult females, with no musculoskeletal or nervous system disorders. The 24 female subjects were divided into two groups: 12 subjects comprised a voluntary stimulation training group, and the other 12 subjects comprised an electrical stimulation training group. A total of thirty contractions were made repetitively by each woman, with maximal voluntary contraction exercise for six seconds, and a resting time of three seconds. During the experiment, their EEG was measured at eight positions. The eight positions were Fpz, Fz, Cz, CPz, C3, C4, P3, and P4, in accordance with the international 10~20 system. Results: The relative alpha power and beta power showed no statistically significant differences between the two groups. But the relative gamma power of the CPz, C3, C4, P3, and P4 areas showed statistically significant differences between the two groups (p<0.05). The relative theta power of the C4 area showed statistically significant differences between the two groups (p<0.05). Conclusion: Our findings show that tibialis anterior muscle contraction by electrical stimulation and by voluntary repeated contraction differentially affected brain activation. In particular, the CPz, C3, C4, P3 positions of relative gamma power showed brain activation in voluntary contraction. The C4 position of relative theta power showed different brain activation between the two groups.

자외선 조사로 유발된 피부 염증성 반응에 맥동성 초음파가 미치는 영향

이정우,박수지,윤세원,Lee, Jeong-Woo,Park, Su-Ji,Yoon, Se-Won 대한물리치료학회 2011 대한물리치료학회지 Vol.23 No.4

Purpose: This study aims to examine the effects of pulsed ultrasound on skin inflammatory reaction induced by ultraviolet irradiation. Methods: Twenty subjects were selected for this study. Inflammatory reaction was induced by ultraviolet irradiation in two areas of the lumbar region of the subjects. Pulsed ultrasound (3 MHz) was applied to one of the two areas of inflammatory reaction at a pulse ratio of 1:4, intensity of $0.5W/cm^2$, once a day for 5 min, and pulsed ultrasound was not applied to the other area. Wound color (chromatic red), luminance (gray) and wound contraction (area) were measured using digital imaging processing method. Results: There was a significant difference in wound color (chromatic red) in the interaction between time and area. There was a significant difference in luminance in the interaction between time and area. There was a significant difference in wound contraction between the two areas. Conclusion: These results indicate that pulsed ultrasound increased the wound contraction rate and reduced the inflammatory reaction activity such as erythema induced by ultraviolet irradiation.

자기 부상 실습 장치의 개발에 관한 연구

이정우,정연두,한명근,Lee Jeong-Woo,Cheong Yeon-Doo,Han Myoung-Keun 한국공학교육학회 2005 공학교육연구 Vol.8 No.1

이 논문은 삼척대학교 메카트로닉스 공학부에서 자동제어, 디지털제어, 마이크로 프로세서응용의 실습을 위해 사용되는 자기 부상실습장치의 설계와 제작에 관한 것이다. 이 장치는 MIT 대학의 설계에서 영감을 받아 개발되었으나, MIT의 장치가 아날로그형임에 비해 디지털형으로 개발하였다. 이 실습장치는 아날로그와 디지털 방식으로 동시에 제어하고 모니터할 수 있다. 더구나 부품의 가격은 MIT의 것과 비슷하거나 더 싼 편이다. 그리고 이 장치는 자기 홀 센서나 적외선 센서를 이용하여 제어할 수 있어서 학생들에게는 센서의 사용과 신호처리를 위한 다양한 경험을 얻을 수 있도록 되어있다. 이 설계는 저자들이 제작하여 시험해 보았으며, 학생들에게 실험 프로젝트 형식으로 제공될 것이다. 이 장치는 의도적으로 덜 보상되어지고, 적당한 수준까지만 조립된 상태에서 학생들에게 제공될 것이며, 학생들은 센서신호와 제어기의 성능을 분석한 후 보상기를 설계하고 센서의 신호를 처리할 것이 기대된다. This paper describes the design and fabrication of magnetic levitation kits for use in the hands on experiments of automatic control, digital control and microprocessor applications in the division of mechatronics in Samcheok university. The kits are developed inspired by MIT's design, but it is designed on the digital basis, whereas MIT's is designed on the analog basis. As a result, the kits can be monitored and controlled on the analog and digital control techniques. Furthermore, the cost of kit components is comparable or lower to that of MIT design. And the kits can be controlled with magnetic hall sensors and/or infrared sensors, which provides more versatile experience on the use of sensors and signal filtering to the students. The design is fabricated and tested by authors and will be provided to the students as lab projects. The kits will be intentionally presented with a device that is poorly instrumented and poorly compensated. And the students are expected to analyze sensor signal and controller performance, and then, perform compensator design and signal filtering.

창출(蒼朮)이 천식 관련 Th1/Th2 세포 분비 cytokine에 미치는 영향

이정우,이형구,정희재,Lee, Jeong-Woo,Rhee, Hyung-Koo,Jung, Hee-Jae 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4

Background and Objective : Atractylodes japonica (AJ) is a commonly-used herbal medicine in Asian countries such as Korea, China and Japan. The present study was designated to evaluate the direct effects of AJ on helper T cell activities and on Th1/Th2 lineage development in vitro. Materials and Methods : Spleen cells from 8-week BALB/c mice were cultured in CR extracts containing medium without activation for 24 hours and with activation for 48 hours. CD4+ T cells were isolated and analyzed for mRNA expression levels of INF-$\gamma$, IL-4, T-bet and GATA-3 by RT-PCR and secretion cytokines levels of INF-$\gamma$, IL-2, IL-4, IL-5 and IL-10 by ELISA. Results : The results demonstrated that AJ had no mitogenic effects on unstimulated CD4+ T cells, but augmented CD4+T-cell proliferation upon activation with anti-CD3/anti-CD28 antibodies in a dose-dependent manner. AJ treatment significantly increased CD4+ T cell population and IFN-$\gamma$ expression was significantly enhanced, while IL-4 expression significantly decreased. In addition, in vitro Th1/Th2 polarization experiments revealed that AJ enhanced IFN-$\gamma$ secretion in Th1 cells, but reduced the IL-4 in Th2 cells in dose-dependent manner. Conclusion : These results suggest that AJ treatment could be a desirable alternative therapy for the prevention or correction of Th2 dominant pathological disorders, such as allergy and asthma.

반도체 capacitive 지문 센서 및 이미지 합성 방법

이정우,민동진,김원찬,Lee, Jeong-Woo,Min, Dong-Jin,Kim, Won-Chan 대한전자공학회 1999 電子工學會論文誌, D Vol.d36 No.2

본 논문에서는 저 비용, 고해상도 반도체 지문 센서칩에 대하여 논한다. 제작된 테스트 칩은 $64{\times}256$ 센싱 셀(sensing cell)로 구성되어 있으며, 칩의 크기는 $2.7mm{\times}10.8mm$이다. sensing cell 내부에서 일어나는 전하 재분포를 감지하는 새로운 방식을 이용하여 내부의 기생 캐패시턴스의 영향을 효과적으로 제거하는 방법을 제안하였다. 제안하는 방법은 센싱 셀의 감지 능력을 키우므로 센싱 셀의 크기를 줄일 수 있고, 따라서 고해상도의 이미지를 추출할 수 있다. 표준 0.6${\mu}m$ CMOS 공정을 이용하여 제작된 칩은 600dpi의 해상도를 가지는 지문 이미지를 추출한다. 제조 단가를 낮추기 위하여 지문의 부분 이미지들로부터 전체 지문 이미지를 얻어내는 이미지 합성 방법의 가능성과 문제점에 대해서도 논의하였다. This paper introduces a possibility of a low-cost, high-resolution fingerprint sensor chip. The test chip is composed of $64{\times}256$ sensing cells(chip size : $2.7mm{\times}10.8mm$). A new detection circuit of charge sharing is proposed, which eliminates the influences of internal parasitic copacitances. This the reduced sensing-capacitor size enables a high resolution of 600dpi, using even conventional 0.6${\mu}m$ CMOS process. The partial fingerprint image captured therefrom are synthesized into a full fingerprint image with a image synthesis algorithm. The problems and possibilities of image synthesis technique are also analyzed and discussed.