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고밀도비 격자 볼츠만 기법을 이용한 마이크로 홀/마이크로 필라 패턴 표면의 소수성 모델링
이정신(Jung Shin Lee),김용현(Yong Hyun Kim),이준상(Joon Sang Lee) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.4
높은 접촉각(CA)을 가지는 특성 때문에 표면 거칠기를 이용한 소수성 표면이 주목 받고 있다. 표면 거칠기는 물과 고체표면 사이에 공기 주머니가 생성될 수 있는 공간을 마련하여 고체표면과 물 사이의 접촉면적을 감소시키고 결과적으로 CA 증가에 영향을 준다. 소수성 표면을 만드는 방법에는 두 가지가 있는데 마이크로 홀 패턴과 마이크로 필라 패턴이 그것이다. 최근에 마이크로 홀 패턴을 가진 표면이 필라 패턴을 가진 표면에 비해 제작이 쉽고 내구성도 더 좋아 높게 평가 받고 있다. 이 논문에서는 홀과 필라 패턴 각각에 물방울을 올렸을 때 물방울의 형상변화에 대해 전산유체 모델링 하였고 CA를 구하였다. 이때 공기와 물의 밀도비가 1000에 가까운 고밀도비의 모델링을 수행하기 위해 격자볼츠만기법(LBM)을 이용하였다. 이 기법을 통해 고체-액체-기체간의 복합 경계면을 계산할 수 있다. The hydrophobicity with surface roughness has been issued to the higher contact angle (CA). Surface roughness affects the CA due to the increased area of solid-liquid interface; this composite interface exhibits strong water repellency due to the various pockets of air entrapped between the surface textures. There are two ways to make hydrophobic surfaces, using micro-hole and micro-pillar. Recently micro-hole textured surface has been highly praised, because manufacture process is easier and it is more durable than the pillar surface structure. In this paper, the CAs for the cases of micro-hole and micro-pillar are measured with the computational fluid dynamics (CFD) modeling. Water droplets are simulated on the surface. The cross sectional shapes of Holes and pillars are rectangular with the same cross-sectional areas. Lattice Boltzmann method is used to analyze the large density difference at the air and the water interface (density ratio is 1:1000). This method can calculate solid-liquid-gas composite interface.
김성배(Sung Bae Kim),김상희(Sang Hee Kim),김상위(Sang We Kim),서철원(Cheol Won Suh),이규형(Kyoo Hyung Lee),이정신(Jung Shin Lee),김해련(Hae Ryun Kim),민영일(Young Il Min),송호영(Ho Young Song),최은경(Eun Kyung Choi),이재원(Jae Won Le 대한내과학회 1995 대한내과학회지 Vol.48 No.5
N/A Objectives: Patients with esophageal cancer and a malignant tracheoesophageal fistula(TEF)have an extremely poor prognosis, with or without treatment. However, the presence of a TEF has historically been considered a relative contraindication to radiation therapy. Methods: To determine the appropriate treatmement(use of radiation therapy)for patients with esophageal cancer and malignant TEF, a review was performed of all such cases, obeserved at Asan Medical Center between 1989 and 1993. Results: 1) Six patients with malignant TEF were seen in total 130 esophageal cancer patients, so the incidence was 4.6%. 2) All of the patients were male, had squamous cell histologies. 3) Dysphagia as initial presenting symptom was a chief complaint in all six patients. 4) The number of TEF formation was one in five of six patients, two in the rest. 5) Three TEFs were developed during radiotherapy, two of them stopped radiation therapy, and one patient continued to treat with hyperfractionated radiation and cured. 6) The median survival length was 33(3-60) weeks after initial tumor diagnosis and 16(2-39) weeks after the first TEF occurred. The duration between initial tumor diagnosis and TEF formation was 17.6(0.6-22) weeks. 7) As a pllliative aim, gastrostomy was done in two patients, jejunostomy in one patient, and stent insertion in the other two patients. Associated symptoms with TEF were markedly improved after stent insertion. 8) The cause of death was sepsis as a resulf of aspiration pnenumonia and lung abscess in five of six patients, and advanced esophageal cancer with lung metastasis in the rest. Conclusion: Early detection and proper management were essential in malignant TEF and esophageal cancer. Stent insertion was good palliation. Radiation therapy might be initiated or continued in the presence of a TEF, and eventual resolution of the fistula might occur. Prospective randomized trials are necessary to define the role of radiation treatment, and further attempts to improve the malignt TEF are required.
김태원 ( Tae Won Kim ),이정신 ( Jung Shin Lee ),정병학 ( Byung Hak Jung ),윤환중 ( Hwan Jung Yun ),장대영 ( Dae Young Zang ),이제환 ( Je Hwan Lee ),김성배 ( Sung Bae Kim ),김상위 ( Sang We Kim ),서철원 ( Cheol Won Suh ),이규형 ( K 대한내과학회 1998 대한내과학회지 Vol.54 No.5
Objectives: The poor survival rates among patients receiving surgery alone for stages II and III non-small cell lung cancer prompted several trials of adjuvant therapy after resection. We performed a prospective phase II study in patients with stage II-IIIA non-small cell lung cancer after resection to evaluate the feasibility, activity and toxicity of the postoperative sequential MVP chemotherapy and radiotherapy. Methods: Between February 1991 and May 1995, 60 patients with resected stage II, IIIA non-small cell lung cancer received 2 cycles of MVP combination chemotherapy (Mitomycin-C 6 mg/m², Vinblastine 6 mg/m², Cisplatin 60 mg/m) within 3 weeks after surgery, followed by thoracic irradiation (5,040 cGy after complete resection and 900 cGy booster to microscopically positive resection margin at 1.8 Gy per fraction) within 3-4 weeks after chemotherapy. Results: Forty nine men and 11 women with a median age of 60.5 years (range 33-81 years) were included. During the median follow-up period of 828 days (61-2,015 days), 25 patients had developed recurrence. Among the 25 failures, 3 were local relapse only and 20 were distant metastasis only and 2 had both local and distant sites of recurrence. Three-year overall survival and event-free survival were 43% and 37%, respectively. Neutropenia of grade I-II was observed only in 13 patients. Eleven patient showed grade I-II radiation pneumonitis and 32 had grade I-II radiation esophagitis, Conclusion: Postoperative sequential MVP chemotherapy and radiotherapy in resected stage II-IIIA non-small cell lung cancer is well-tolerated and shows interesting activity,
김태원(Tae Won Kim),이정신(Jung Shin Lee),최성준(Sung Jun Choi),최종수(Jong Soo Choi),장대영(Dai Young Zang),이제환(Je Hwan Lee),김성배(Sung Jun Choi),김상위(Sang We Kim),서철원(Cheol Won Suh),이규형(Kyoo Hyung Lee),김우건(Woo Kun Ki 대한내과학회 1997 대한내과학회지 Vol.52 No.2
N/A Objectives: The advent of intense combination chemotherapy has transformed aggressive non-Hod-gkins lymphoma from a disease that was once uniformly fatal to one that is now often curable. Remission rates and survival may be improved by using intensive chemotherapy regimens. However, this more aggressive approach is inevitably associated with increased toxicity, and an accurate pretreament prognostic assessment of patients is required to guide the physician in selecting the most appropriate therapeutic regimen. Many studies have reported prognostic factors of non-Hodgkins lymphoma in western countries, but there are few reports on prognostic factors in Koreans and it is suggested that clinical characteristcs of non-Hodgkins lymphoma in Korea differ from those in western countries. The purpose of this study was to illustrate clinical characteristics, prognostic factors and treatment outcome in non-Hodgkins lymphoma in Korea. Methods: Clinical features of 151patients (age over 15years) with non-Hodgkins lymphoma registered at Asan Medical Center from March 1989 to December 1993 were retrospectively reviewed. Prognostic factors and treatment outcome were evaluated among 121previously untreated patients. Multi variate analysis of potential pretreatment prognostic factors was performed using Coxs proportional hazards model. Results: Of the 151patients evaluated, 55% had diffuse large cell type, while low-grades were encountered in less than 1% of the patients. Extranodal involvement was noted in 76% of the patients. Cental nervous system was the commonest primary extranodal site, followed by stomach. Complete remission was achieved in 73 of 121patients (60%). The median follow-up for 121patients was 24months and the actuarial overall survival was 48% at 3years and 44N at 5years with a median overall survival of 33months. At the median followup of 32months, the actuarial 5year disease-free survival rate among 73patient with complete remission was 65% and median remission duration was not reached. Presence of systemic B symptoms and advanced clinical stages were associated with a low complete remission rate. None turned out to be associated with the remission duration. The Coxs proportional hazards model identified age above 60years, presence of systemic B symptoms and elevated LDH level as significant independent poor prognostic factors influencing overall survival. Conclusion: This study reveals a low prevalence rate of the low-grades lymphoma and a higher propensity of diffuse large cell type. These results suggest that clinical characteristics of non-Hodgkins lymphoma in Korea are different from those in the western countries. Our data also show that certain pretreatment clinical factors can help in predicting survival and in planning treatment.