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관상동맥질환에서 운동부하 Tc - 99m Tetrofosmin 심근스캔의 진단적 유용성 : 운동부하심전도검사와의 비교
최지용(Ji Yong Choi),황진용(Jin Yong Hwang),황종현(Jong Hyeon Hwang),임현주(Hyeon Ju Lim),박헌식(Hun Sik Park),조용근(Yong Keun Cho),채성철(Shung Chull Chae),전재은(Jae Eun Jun),박의현(Wee Hyun Park),안병철(Byeong Cheol Ahn),이재태(J 대한내과학회 1997 대한내과학회지 Vol.53 No.6
N/A Objectives: Tetrofosmin is a new Tc-99m labeled myocardial perfusion imaging agent that shows slow clearance from the myocardium and rapid clearance from background organs. The purpose of this study was to assess the ability of exercise Tc-99m tetrofosmin single photon emission computed tomography(SPECT) to identify and localize coronary artery disease. Methods : The study population consists of 49 patients with suspected coronary artery disease who underwent both exercise Tc-99m tetrofosmin SPECT and coronary angiography within 2 weeks. Using the one day imaging protocol, 7-10mCi of Tc-99m tetrofosmin was injected at rest and 4 hours later, 25 mCi of Tc-99m tetrofosmin was injected at peak exercise. Results: The sensitivity and specificity of exercise Tc-99m tetrofosmin SPECT was 94.9% and 60% for detection of coronary artery disease with luminal narrowing more than 50%, and 96.4% and 33.3% for detection of coronary artery disease with luminal narrowing more than 70%. The sensitivity of exercise Tc-99m tetrofosmin SPECT for detection of individual stenosed vessels(≥50% and ≥70% coronary stenosis) was 79.2%, 100% for LAD, 55.6%, 55.6% for LCx and 85.0%, 92.9% for RCA and the specificity was 88.0%, 75.0% for LAD, 100%, 87.5% for LCx, 86.2%, 77.1% for RCA respectively. Conclusion: Exercise Tc-99m tetrofosmin SPECT appears to be an feasible and useful noninvasive test for the diagnosis of coronary artery disease