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Ti-6Al-4V 레이저 클래딩부에 대한 미세조직 분석
최병학(Byung Hak Choe),이유철(You-Cheol Lee),조재훈(Che-Hoon Cho) 대한용접·접합학회 2021 대한용접·접합학회지 Vol.39 No.3
The microstructure and phase configuration of Ti-6Al-4V laser cladding were investigated in this study. The cladding microstructures were divided into the base metal of the substrate and heat-affected zone (HAZ), and the weld metal of the weld. However, depending on the location, the microstructure shapes were different, owing to heat transfer effects. The final solidification area of the weld metal had a fine structure because of the rapid cooling on contact with the air layer rather than at the center. HAZ also exhibited a relatively fine structure, owing to the rapid cooling of the substrate contact. All microstructure compositions consisted of a lamellar structure of a lean V-content α phase and a rich V-content β phase. The lamellar spacing in the HAZ was 0.5 μm, which was narrower than the 1.5 μm weld metal. However, the average hardness of the HAZ was lower than that of the 500 HV weld metal because of the low alloy content in the HAZ area, as it was welded on a pure Ti substrate. The alloy content of the weld metal welded using Ti-6Al-4V constituent electrodes was high; therefore, the estimated hardness value was high despite the coarse microstructure. In the weld area, cracks were formed in the HAZ because of the pores generated through the separation of oxides and weld residual stresses. The microstructure, phase configuration, and defects of Ti-6Al-4V laser cladding were identified, and the cladding is useful for the cladding process.
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알콜리즘에서 Buspirone에 대한 Cortisol과 Prolactin 반응
심주철,이정구,김정익,이유철,김영훈 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2
연구목적: 본 연구는 buspirone에 대한 cortisol과 prolactin 반응을 통해 알콜리즘에서 5-HT1A 수용체기능을 조사하고자 하였다. 방법: 알콜리즘 환자군은 DSM-IV의 알콜리즘 진단기준에 부합되고 금주기간이 최소 3개월 이상이며 우울 및 불안증상이 없는, 한 정신병원 알콜 센터에 입원한 22명의 남자 환자였다. 대조군은 정상성인 남자 15명이었다. 이들에게 오전 9시에 5-HT□ 효현제인 buspirone 30mg을 경구 투여한 후 0, 30 , 60, 90, 120, 150분의 혈청 cortisol과 prolatine 농도를 측정한다. 결과: 환자군과 대조군간에 cortisol 기저치에는 유의한 차이가 없었다. Buspirone 투여 후 혈청 cortisol 농도는 정상대조군에서는 기저치에 비해 유의한 증가를 보였으나(p<0.01) 환자군에서는 유의환 증가가 없었다. 혈중 cortisol 농도는 buspiron 투여 60분 이후부터 환자군에서 정상 대조군에 비해 유의하게 저하되어 있었다(p<0.05). Buspirone에 대한 혈청 prolactin 반응은 환자군과 정상대조군간에 유의한 차이가 없었다. 결론: Buspirone 투여 후 둔마된 혈청 cortisol 반응을 통해 알콜리즘에 5-HT1A 수용체 반응성이 둔마되어 있음을 확인할 수 있었다. Objectives: The purpose of this study was to evaluate the prolactin and cortisol responses to 5-HT1A receptor activation by buspirone in alcoholics. Methods: The subjects were twenty two male alcoholic patients meeting the DSM-IV criteria for alcohol dependency and abstaining for more than 3 months. Patients were free from overt anxiety and depressive symptoms. Controls were fifteen male normal volunteers, with no psychiatric and medical illness. Blood samples for the measurement of serum cortisol and prolactin levels were drawn 0, 30, 60, 90, 120, 150 minutes after oral administration of 30mg buspirone hydrochloride at 9:00a.m. Results: The baseline cortisol levels were not significantly different between alcoholics and controls. Serum cortisol levels of controls after buspirone administration were significantly increased over time(p<0.01), but those of alcoholics did not increased. After 60 minutes following buspirone administration, cortisol levels were significantly lower in alcoholics than in contrlos(p<0.05). Prolactin responses to buspirone were not significantly different between the two groups. Conclusions: Our results suggested that 5-HT1A receptor function is decreased in alcoholic patients.
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