고압산소(高壓酸素)가 폐조직(肺組織)에 미치는 영향(影響)과 DL-α-Tocopherol의 내성효과(耐性效果)에 관(關)한 연구(硏究)

이원창,윤화중,Lee, Won Chang,Yoon, Wha Joong 대한수의학회 1975 大韓獸醫學會誌 Vol.15 No.1

Experimental studies were performed to observe the effect of exposure to 100% oxygen in 2 atmospheres on the lung tissue of rats, and to examine the resistant effect of DL-${\alpha}$-tocopherol. The following results were made through this experiment: 1. Half-lethal time by oxygen poisoning was longer in tocopherol treated group than not treated group. 2. Ratio of lung weight to body weight was significantly higher in fatal group within half-lethal time than survival group (p<0.01). 3. Histopathological changes of the lung by oxygen toxicity were vascular congestion, pulmonary edema, hemorrhage and emphysematous change. The degree of changes were rather marked in experimental group than tocopherol untreated group. Those were regard as the changes being occurred during tolerance process by prolonging half-lethal time.

뇌실질내출혈을 동반한 중대뇌동맥류 파열 환자의 예후 인자

이원창,최창화,Lee, Won Chang,Choi, Chang Hwa 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

Objective : The purpose of this study was to investigate the prognostic factors in patients who suffered an intracerebral hemorrhage(ICH) due to a ruptured middle cerebral artery(MCA) aneurysm. Methods : Among 148 case of ruptured MCA aneurysm, ruptured MCA aneurysm with ICH was compared with ruptured MCA aneurysm alone. According to factors, the prognosis in these two groups was analyzed. Prognosis was evaluated postoperatively by applying Glasgow Outcome Scale(GOS) at discharge. Prognostic factors were evaluated with Chi square test, Mann-Whitney test and ANOVA test with differences being considered significant for value less than 0.05. Results : Ruptured MCA aneurysm alone revealed better consciousness on admission and final outcome than those combined with ICH. Ruptured MCA aneurysm alone showed 74% in H-H grade I, II and 82% in GOS I, II. But ruptured MCA aneurysm with ICH showed 63% in H-H grade IV, V and 52% in GOS IV, V. Age, sex, lesion site, aneurysmal size, temoporary clipping time, interval to operation, operative approach were statistically not significant in prognosis(p>0.05). But H-H grade on admission(p<0.05), complication(esp. cerebral infarction)(p<0.05), preoperative ICH volume and site(p<0.01), preoperative midline shifting(p<0.01), remained ICH volume(p<0.05) showed significance statistically. Conclusion : Prognostic factors are helpful to neurosurgeon to estimate clinical and neurological outcome postoperatively. We suggest that the good prognostic factors in ruptured MCA aneurysm with ICH were good H-H grade on admission, cerebral infarction(-), preoperative ICH volume <25cc, temporal and intrasylvian ICH, preoperative midline shifting <5mm, remained ICH volume <10cc.

경주마(競走馬)와 제주마(濟州馬)의 생리적(生理的) 골경도(骨硬度)에 관하여

이원창,김효중,신태홍,Lee, Won Chang,Kim, Hyo Jung,Shin, Tae Hong 대한수의학회 1974 大韓獸醫學會誌 Vol.14 No.2

Although considerable research has been done on the blood chemistry of domestic animals, little work has been made of the changes associated with age. Moreover, the records about physiology of the goat were not much available in Korea, and a comprehensive survey of the blood chemical values of the Korean native goat has not been made. The authors intended to biometric study on the hardness of bone of race horse and Jeju horse in Korea. The measurement of hardness of bone were performed in 272 race horses (Thoroughbred 91, Anglo-Arab 107, Arab 74) and in 109 Jeju horses by the caliper by Toryba's method. Some interesting facts obtained through this study were as follows: 1. There was not significant difference of bone hardness between male and female. The average of bone hardness by the Toryba's meteod were $23.07{\pm}1.01$ in race horse and $19.44{\pm}1.84$ in Jeju horse. 2. The grade of bone hardness of race horse were higher than those of Jeju horse(P<0.001). 3. The correlation coefficient between age and grade of bone hardness were r= +0.344 in Jeju horse, theme were statistically significant (P<0.01) and the regression equation was Y=0.29x+18.497.

자발성 지주막하출혈 후 발생하는 수두증에 대한 단락술의 필요성 및 예후에 관한 분석 - 뇌실외배액술의 기간, 일일배액량 및 총배액량과 예후관계 -

이원창,최창화,Lee, Won Chang,Choi, Chang Hwa 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

Objective : Hydrocephalus and vasospasm are the common complications following subarachnoid hemorrhage (SAH). In spite of development of perioperative management and operative technique, hydrocephalus cause neurological deficit and poor prognosis. Usually CSF drainage procedure(external ventricular drainage(EVD) or shunt) is needed in hydrocephalus following SAH. The aim of this study was to investigate whether the need for shunting and the outcome after shunting in hydrocephaus following SAH can be related to the duration, daily and total amount of cerebrospinal fluid(CSF) drainage at EVD. Material and Method : IVH is one of several factors which cause hydrocephalus. In this retrospective study, firstly we investigated the incidence of IVH in total cases and frequency of IVH according to aneurysmal site and then prognosis of IVH following SAH. Among 629 patients with SAH, hydrocephalus was diagnosed by CT scan and symptoms. And then those 102 hydrocephalus following SAH were divided into two groups which were hydrocephalus with IVH group and without IVH group. In these two groups, we investigated and compared the incidence of hydrocephalus in all case, frequency of hydrocephalus according to aneurysmal site, the outcome according to H-H grade on admission and the need rate of shunt, etc. Of those hydrocephalus, 100 EVD procedures were done. The duration, daily and total amount of CSF drainage at EVD were investigated. Fifty cases expired during EVD was excluded. We analyzed whether the need rate of shunt and the final outcome after shunting can be related to IVH, the duration and daily and total amount of CSF drainage. Result : The incidence of hydrocephalus following SAH was 20%(with IVH group ; 64%, without IVH group ; 11%). As H-H grade on admission was better, the outcome of hydrocephalus was also better. The mortality rate of hydrocephalus with IVH was 64% which was higher than 40% that of hydrocephalus without IVH. The need rate of shunt in all cases of hydrocephalus following SAH was 20%, but those with IVH group excluding expired patients before shunt was 40%. This was very similar to 41% of the need rate of shunt in hydrocephalus without IVH. The total amount of CSF drainage was statistically related to the need rate of shunt(total amount : need rate of shunt/<1000cc : 15%, 1000-2000cc : 40%, >2000cc : 50%). The duration and daily amount of CSF drainage were not statistically related to the need rate of shunt, but as daily amount of CSF drainage was more and duration was longer, the need rate of shunt was increased(daily amount : need rate of shunt /<100cc : 16%, 100-200cc : 25%, >200cc : 40%//duration : need rate of shunt/<1week : 8%, 1-2weeks : 30%, >2weeks : 47%), and also the final outcome after shunting was poor. Especially the total amount of CSF drainage was significant related to the final outcome after shunting(total amount : GOS/<1000cc : I&II(3/4), 1000-2000cc : II(2/4), III(2/4), >2000cc : III&IV(6/7)). Conclusion : This study revealed that the incidence and mortality rate of hydrocephalus following SAH were influenced by IVH. So SAH associated IVH has the higher incidence of hydrocephalus and poor outcome. As the CSF drainage amount was more and duration of drainage was longer, the need rate of shunt was increased and the final outcome after shunting was poor. Especially the total amount of CSF drainage were strongly related to the need rate of shunt and the outcome after shunting.

농약이 가축위생에 미치는 영향(1)

이원창,Lee, Won-Chang 대한양돈협회 1984 養豚 Vol.6 No.5

고압산소환경(高壓酸素環境)에서의 산소중독(酸素中毒) 및 내성(耐性)에 관(關)한 실험적(實驗的) 연구(硏究)

이원창,Lee, Won-Chang 대한수의학회 1969 大韓獸醫學會誌 Vol.9 No.1

Experimental studies were performed to observe the difference in tolerance of small animals to oxygen poisoning, and also to examine the effects of certain drug for it. The three experimental groups consisted of mature rat group, immature rat group and mouse group. The animals were exposed to 5 atm. of 100% oxygen using hyperbaric chamber, and they were observed for oxygen poisoning by pulmonary and central nervous system manifestation. The tolerance to oxygen poisoning was represented by half fatality time in each experimental group. The drug applied was ammonium chloride $NH_4Cl$ and it was administered intraperitoneally in various dosages for particular attribution of its prophylactic effect. The following conclusions were made; 1. The immature rat group showed the higher degree of tolerance to oxygen poisoning, as evidenced by a more prolonged half fatality time in the group. No significant difference in the half fatality time between the mature rat and the mouse group was observed. 2. The fact that the immature group showed the higher degree of tolerance as compared with the mature rat group represented by delayed onset of convulsion. 3. There was a remarkable difference in the Lung Weight/Body Weight ratio between the experimental and control group. 4. The animals with a shorter half fatality time uniformally displayed an earlier onset of convulsive seizure as the sign of oxygen poisoning and a significant elevated Lung Weight/Body Weight ratio. 5. Ammonium chloride at the dosage of 450mg per kg body weight had the most pronounced prophylactic effect on oxygen poisoning.

직교변환에 의한 Walsh 및 Golay 코드의 상호상관 제어방식과 수정된 코드를 사용한 비동기 CDMA 시스템의 비트오율 성능에 관한 연구

이원창,김명진,Lee, Won-Chang,Kim, Myoung-Jin 한국융합신호처리학회 2008 융합신호처리학회 논문지 (JISPS) Vol.9 No.4

Walsh 코드나 Golay 코드와 같은 직교 코드는 동기가 맞지 않은 경우 상호상관 값이 커질 수 있으므로 CDMA 시스템의 역방향 링크와 같이 사용자간 동기가 맞지 않는 경우 직교성이 손상되어 사용자간 간섭이 발생하기 때문에 사용자 구별용으로 거의 사용되지 않는다. Wysocki는 기존의 Walsh-Hadamard 행렬에 직교변환 행렬을 곱함으로써 생성된 코드들이 직교성을 유지하면서 코드간 상호상관 값이 커지지 않도록 할 수 있음을 보였다. Soberly와 Wysocki는 Golay 코드에 대해서 유사한 상호상관 함수의 제어방식을 제안하였다. 이것은 적절한 직교변환을 사용하면 Walsh 코드나 Golay 코드의 상호상관 값을 감소시킬 수 있고, 따라서 CDMA 역방향 링크에서 사용자 구별용으로 사용될 수 있음을 의미한다. 본 논문에서는 비동기 CDMA 링크의 성능에 영향을 주는 코드간의 상호상관 관련 파라미터들을 알아보고, 직교변환에 의해 이들 파라미터들이 어떻게 변화되는지 분석하였다. Walsh 코드와 Golay 코드에 대한 직교변환 행렬을 설계함에 있어 수정된 Walsh 또는 Golay 코드의 직교성을 유지하면서 결과 코드의 비주기 상호상관 피크치의 최대값($ACC_{max}$) 또는 비주기 상호상관의 제곱평균($R_{cc}$)을 최소화하도록 하였다. 직교변환에 의해 생성된 코드집합을 사용한 CDMA 시스템에 대하여 사용자간 동기가 맞지 않은 경우에 대해 비트오율 성능을 시뮬레이션을 통해 분석하여 성능을 개선시킬 수 있음을 확인하였다. Orthogonal codes like Walsh and Golay codes may have large correlation value when they are not synchronized, hence they are seldom used in asynchronous CDMA systems. Wysocki[1] showed that by multiplying the original Walsh-Hadamard matrix with an orthogonal transformation matrix the resultant matrix sustains orthogonality between row vectors and their cross-correlation can be reduced. Soberly and Wysocki[2] proposed similar scheme on Golay codes. This implies that using the proper orthogonal transformation cross-correlation of Walsh and Golay codes can be reduced, and the transformed codes can be used for user separation in the CDAM reverse link. In this paper we discuss cross-correlation related parameters which affect the performance of an asynchronous CDMA link, and we investigate the correlation properties of the transformed codes. When we designed orthogonal transformation matrices for Walsh and Golay codes, we minimized the maximum value of aperiodic cross-correlation of the codes ($ACC_{max}$) or the mean square value of the aperiodic cross-correlation($R_{cc}$) with preserving the orthogonality of the modified codes. We also evaluate the asynchronous CDMA system that uses the transformed Walsh and Golay codes.

어느 교사의 푸념

이원창,Lee, Won-Chang 한국대학교육협의회 2003 大學敎育 Vol.121 No.-

수의과학에서의 공중보건학교육

이원창,Lee, Won-Chang 한국대학교육협의회 1986 大學敎育 Vol.23 No.-

소 질병의 문제점과 대책

이원창,Lee Won Chang 대한수의사회 1979 대한수의사회지 Vol.15 No.2