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국내 평가 가이드 라인 제시를 위한 전동식 부항기의 특성 조사에 관한 연구
이승호,김은정,신경훈,남동우,강중원,이승덕,이혜정,이재동,김갑성,Yi, Seung-Ho,Kim, Eun-Jung,Shin, Kyung-Hoon,Nam, Dong-Woo,Kang, Jung-Won,Lee, Seung-Deok,Lee, Hye-Jung,Lee, Jae-Dong,Kim, Kap-Sung 대한침구의학회 2010 대한침구의학회지 Vol.27 No.1
Objectives : The mechanical properties of Korean electric cupping systems are studied via experimental measurements. The study aimed at establishing the fundamentals of industrialization and systemization of oriental medicine device industry, as well as improving the quality of life for many Koreans. Methods : We reviewed the studies on traditional cupping as well as modern one to fine necessary factors for electric cupping systems. To characterize the mechanical properties of Korean electric cupping systems, we measured the pressure characteristics of commercially available electric cupping system by using an automatic pressure acquisition system and a standard cup. The pumping capability was checked at 40 seconds, and the stability of the suction cup was checked at 600 seconds. We also acquired the noise level of each system in clinical setting. To check the portability of each system, we also measured its physical dimensions. We scrutinized system manuals provided by the system manufacturers. Results : It took less than 5 second to reach the pressure if the connection between the air hose and the vacuum valve of the cupping system was secure. Pressure diminished to no more than 10% for 600s for all systems. Noise levels were 55~70 dB. Increase in pressure was too fast to control for a designated vacuum level except for one product. Conclusions : The Pumping ability of the systems is impressive and reliable. Pressure retention ability of each cup is quite reliable and reproducible. Therefore, their mechanical performances were worthy of recommendation. Some of them had noise level higher than 60 dB and they were bothersome. It was also suggested that the control for low to middle pressure needed to be accomplished by the cupping system.
소아 Henoch-Schölein purpura에서 전환성장인자-β 프로모터유전자의 유전학적 다형성과 신장침범의 관련성
이승호,지화영,김황민,예병일,Lee, Seung Ho,Jee, Hwa Young,Kim, Hwang Min,Yeh, Byung Il 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.5
Purpose : Several cytokines play important roles in the inflammatory process of Henoch-$Sch\ddot{o}lein$ Purpura (HSP). It is likely that transforming growth $factor-{\beta}$ ($TGF-{\beta}$) is involved in the pathogenesis of HSP. The purpose of this study is to investigate whether $TGF-{\beta}$ promoter polymorphism is associated with the renal involvement of childhood HSP. Methods : Thirty-four patients younger than 15 years, who had been diagnosed with HSP, as well as 27 controls, were examined. Patients and controls were genotyped for $TGF-{\beta}$ C-509T by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results : The T allelic frequencies in patients and controls showed no difference (45% vs. 48.8%). No allele or genotype differences between the group of HSP group and control group were observed. The frequencies of $TGF-{\beta}$ 509 genotypes TT, TC, and CC were no different between patients and controls (26% vs. 22%). The TT genotype of polymorphism of the $TGF-{\beta}$ C-509T gene had no relation to the susceptibility of children to HSP and renal involvement in HSP. Conclusion : $TGF-{\beta}$ T allele may not be related to the susceptibility of children to HSP. The TT genotype of polymorphism of the $TGF-{\beta}$ C 509T gene does not appear to have an influence on renal involvement in childhood HSP. 목 적 : HSP는 소아에서 흔한 전신성 혈관염으로 명확한 병인은 밝혀지지 않았으나 염증성 시토카인들이 발병기전에 관여하는 것으로 여겨지며 그중 전환성장인자-${\beta}$가 HSP의 발병기전과 연관이 있는 것으로 보여진다. 본 연구의 목적은 전환성장인자-${\beta}$ 프로모터 유전자의 유전학적 다형성과 HSP 환자에서의 신장 침범과의 관련성을 조사하고자 하는 것이다. 방 법 : 2003년 6월부터 2005년 6월까지 연세대학교 원주기독병원 소아과를 방문하여 HSP로 진단받은 15세 이하 환아 34명과 같은 기간 본원을 방문한 정상 대조군 27명을 대상으로 하였다. 전환성장인자-${\beta}$ 다형성 유전자 표현형은 PCR-RFLP로 환자군과 대조군에서 시행하였다. 결 과 : HSP 환자군과 대조군에서 전환성장인자-${\beta}$ 프로모터 유전자 다형성의 T 대립유전자 빈도는 각각 45%, 48.8% 였으며, T 대립유전자 빈도 간에 통계학적으로 유의한 차이는 없었다(P=0.37). TT 유전자 표현형도 환자군과 대조군에서 빈도의 차이가 없었고(26% vs. 22%, P=0.37), 환자군 중 신장 침범에 있어서도 유의한 차이가 나타나지 않았다(29% vs. 20%, P=0.77). 결 론 : 전환성장인자-${\beta}$ 유전자 다형성의 TT 표현형과 T 대립유전자의 빈도가 HSP 환아의 질병 감수성이나 신장침범과의 연관성을 보임을 관찰할 수 없었으며 HSP 환자들에게 있어서 보다 큰 집단을 대상으로 하는 연구가 전환성장인자-${\beta}$와 신장침범 및 질병 감수성과의 연관성을 명확히 하는데 필요할 것으로 보인다.
이승호,Lee, Seung-Ho 한국국방경영분석학회 2005 한국국방경영분석학회지 Vol.31 No.1
Korea DM&S(Defence Modeling & Simulation) development plan includes construction of a distributed simulation model which enables us to construct, operate, integrate and connect war game simulations. US DoD and IEEE set the HLA/RTI as the standard of distributed simulation model. HLA/RTI models each simulator as a Federate and group of them as a Federation. Simulation with the model shows interoperability and finally executes a war game simulation. Because of different resolutions and features, it is not satisfied 'interoperability' and 'reusability' of simulation perfectly MRM (Multi Resolution Modeling) has been introduced, and many developed countries including the United States have studied the technology to simulate the model with different resolutions. This thesis proposes the need for introduction of MRM and analyzes both technical and operational validity when we apply MRM model to army war game simulations. For these purposes, we 1) find MRM main issues with the study about MRM basic concepts and case studies of MRM's applications, 2) present the need of MRM and its relation with DM&S development plan, and 3) analyze its technical and operational validity when we apply MRM to an example, CHANG-JO21 and JEON-TOO21.
이승호,이준영,박정주,Lee, Seoung-Ho,Lee, Jun-Young,Park, Jung-Ju 대한치과마취과학회 2004 Journal of Dental Anesthesia and Pain Medicine Vol.4 No.1
Chronic periodontitis is one of the most common disease in clinical dentistry, which needs various surgical interventions to treat the moderate to severe destruction of supporting periodontium. Most patients have fear and anxiety to these surgical procedures and some dentists also have problems to deal with these patients. Applying the conscious sedation technique in outpatient units, periodontists have become to manage their patients successfully without any fear and anxiety and increased the level of patients' satisfaction. Particularly, periodontal treatments require relative long chair-time and patients are usually reluctant to the periodontal instruments used in the oral cavity. This study is focused on the sedation procedure with intravenous midazolam infusioon performed in Department of Periodontology, Ewha Womans University Hospital. The whole procedure of intravenous midazolam sedation is briefly reviewed from patient selection to patient discharge.
누드마우스에서 골 형성에 대한 BMP와 PDGF 복합사용의 효과
이승호,최병호,주석강,허진영,정재형,김병용,Lee, Seoung-Ho,Choi, Byung-Ho,Zhu, Shi-Jiang,Huh, Jin-Young,Jung, Jae-Hyung,Kim, Byung-Yong 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.2
Bone morphogenetic protein(BMP) and platelet-derived growth factor(PDGF) have been demonstrated tostimulate bone formation when applied locally in vivo. To explore whether or not the combined use of BMP and PDGF could have promotive effect and synergic interaction on bone formation in vivo, bone marrow mesenchymal stem cells were treated with BMP-2, PDGF-BB, or BMP-2 plus PDGF-BB, and then these cells were injected into the subcutaneous space on the dorsum of nude mice. The bone formation was evaluated after 12 weeks. Histomorphometric analysis demonstrated that the subcutaneous nodules formed in nude mice contained 25.3% newly formed bone in the BMP-2 treated cells, 14.4% newly formed bone in the PDGF-BB treated cells, and 8.9% newly formed bone in the RMP-2 plus PDGF-BB treated cells. The results showed that the combination of BMP-2 and PDGF-BB had neither a promotive effect nor synergic interact on bone formation in vivo.