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우르소데옥시콜린산 및 케노데옥시콜린산의 베타시클로덱스트린 포접복합체의 물리화학적 특성비교
이승룡,정연복,한건,신재영,Lee, Seung-Yong,Chung, Youn-Bok,Han, Kun,Shin, Jae-Young 대한약학회 1994 약학회지 Vol.38 No.3
Physicochemical properties for the inclusion complex of chenodeoxycholic acid(CDCA) and it's $7{\beta}-hydroxy$ epimer ursodeoxycholic acid(UDCA) with ${\beta}-cyclodextrin({\beta}-CyD)$ were studied. The formation of the complex in the solid state were confimed by polarized microscopy and differential scanning calorimetry(DSC). Proton nuclear magnetic resonance$(^1H-NMR)$spectroscopy showed that CDCA and UDCA form an inclusion complex with ${\beta}-CyD$ in aqueous solution. The 1 : 1 stoichiometry of the complex was dextermined by the continuous variation method. From DSC and $^1H-NMR$ studies, there were not any differences between CDCA and UDCA. Complex of CDCA and UDCA showed increase in solubility and dissolution compared with CDCA and UDCA alone, respectively. Solubility pattern of UDCA complex was pH independent but, CDCA complex was like that of CDCA. Dissolution rate increased markedly in case of UDCA complex compared with CDCA complex, especially in acidic pH value.
김수육군전(金水六君煎)이 $SO_2$에 의한 흰쥐의 호흡기조직손상(呼吸器組織損傷)에 미치는 영향(影響)
이승룡,박동일,Lee, Sung-Yong,Park, Dong-Il 한국한의학연구원 1996 한국 한의학연구소 논문집 Vol.2 No.1
This experiment was performed in order to study the effects of Gyumsuyukgunjun on the injured tracheal tissue induced $SO_2$ in rats. Healthy adult male rats weighting about 250g were divided into 4 groups - the Normal group, the Control group, the group of Gyumsuyukgunjun administration for 5 days after $SO_2$ gas exposure (Sample I), and the group of Gyurnsuyukgunjun administration for 10 days before and for 5 days after $SO_2$ gas exposure (Sample II). The results were obtained as follows ; 1. In the trachea Control group, the lesion of the ciliated epithelium was severe and the mucus secretion of the respiratory tract was increased significantly. 2. In the trachea of Sample I group, the lesion of the ciliated epithelium and the mucus secretion of the respiratory tract were decreased compared with Control group. 3. In the trachea of Sample II group, the lesion of the ciliated epithelium and the mucus secretion of the respiratory tract were decreased compared with Control and Sample I group. According to the above results, Gyumsuyukgnjun has significant effects on the injuried tracheal tissue caused by $SO_2$ in rats.
폐암 조직에서의 PTEN 발현 정도와 Gefitinib의 반응율과의 관계
이승룡 ( Sung Yong Lee ),이주한 ( Ju Han Lee ),정진용 ( Jin Yong Jung ),이경주 ( Kyoung Ju Lee ),이승현 ( Seung Hyeun Lee ),김세중 ( Se Joong Kim ),이은주 ( Eun Joo Lee ),허규영 ( Gyu Young Hur ),정기환 ( Ki Hwan Jung ),정혜철 ( H 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.5
Propylthiouracil 약제 복용으로 유발된 미만성 폐출혈
이승룡 ( Sung Yong Lee ),정진용 ( Jin Yong Jung ),이경주 ( Kyoung Ju Lee ),이승현 ( Seung Hyeun Lee ),김세중 ( Se Joong Kim ),이은주 ( Eun Joo Lee ),허규영 ( Gyu Young Hur ),정혜철 ( Hae Chul Jung ),이상엽 ( Sang Yeub Lee ),김제형 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.1
Propylthiouracil(PUT) is a drug which used at Grave`s disease. But PTU has recently been observed to associated with antineutrophil cytoplasmic antibody(ANCA)-positive vasculitis resulting in, infrequently, diffuse alveolar hemorrhage. We report the case
증례 : 소화기 ; 고립 상장간막동맥박리로 스텐트 삽입 후 발생한 상장간막 동맥증후군
이승룡 ( Seung Ryong Lee ),김성훈 ( Seong Hun Kim ),남상우 ( Sang Woo Nam ),김인희 ( In Hee Kim ),김상욱 ( Sang Wook Kim ),이승옥 ( Seung Ok Lee ),이수택 ( Soo Teik Lee ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
상장간막동맥증후군은 대동맥과 상장간막동맥이 이루는 각이 줄어들면서 십이지장의 폐쇄를 유발하는 매우 드문 질환이다. 여러 의학적 혹은 정신적 질환에 의해 급격한 체중감소가 발생하면 십이지장 제3부가 통과하는 대동맥과 상장간막동맥 간의 공간에 지방조직이 줄어서 발생하게 된다. 고립 상장간막동맥박리는 급성 장간막 허혈의 매우 드문 원인 중 하나인데, 장경색을 유발하거나 상장간막동맥의 파열의 위험이 높은 박리증의 치료는 응급수술이 우선이고, 생체활력징후가 정상이고, 증상이 심하지 않은 경우엔 보존적인 치료를 시행할 수 있다고 알려져 있다. 최근 몇몇 문헌에서 고립 상장간막동맥박리 때 경피 혈관 스텐트삽입술로 장경색으로의 진행을 막고 단기 예후가 좋다고 보고하고 있으나, 장기 예후에 관한 보고가 없고, 스텐트 관련 합병증이 보고된 것이 적어서, 혈관 스텐트삽입술의 안정성이 명확하게 밝혀지지 않은 상황이다. 본 저자들은 고립 상장간막동맥박리로 인한 급성 장간막 허혈로 경피 혈관 삽입술을 시행 후 발생한 상장간막동맥증후군 합병증을 치료한 증례를 최초로 경험하여 보고하는 바이다. Superior mesenteric artery (SMA) syndrome is a rare disorder, characterized by a decreased aortomesenteric angle that causes a duodenal obstruction. Various medical and psychiatric conditions may result in the initial rapid weight loss that causes narrowing of the aortomesenteric angle. Isolated dissection of the superior mesenteric artery (DSMA) is an uncommon cause of acute mesenteric ischemia. Several literature reports suggest that medical treatment in combination with close observation is reasonable in uncomplicated dissection with stable hemodynamic status. Recently, as several reports describe, rapid revascularization by percutaneous angioplasty and endovascular stent insertion can prevent bowel ischemia that progresses to irreversible bowel necrosis. However, the stability of endovascular stents at the DSMA has not been confirmed, because its use is reasonably infrequent. Here, we report a case of SMA syndrome, as a complication of endovascular stent placement at the DSMA. (Korean J Med 2011;80:S67-S72)
Ovalbumin으로 유발된 백서의 즉시형 기관지 수축 반응에서 Cyclooxygenase-2 (COX-2) 발현 양상 및 혈중 프로스타글란딘 E2 농도와 COX-2 억제제의 효과
이승룡 ( Sung Yong Lee ),이신형 ( Sin Hyung Lee ),정기환 ( Ki Hwan Jung ),김병규 ( Byung Gyu Kim ),정혜철 ( Hae Chul Jung ),김경규 ( Kyung Kyu Kim ),권영환 ( Young Hwan Kwon ),김제형 ( Ja Hyeong Kim ),이주한 ( Ju Han Lee ),이상엽 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.48 No.2
원인을 알 수 없는 만성 기침의 기관지 생검소견과 경구 스테로이드의 효과
이상엽 ( Sang Yeub Lee ),정혜철 ( Hye Cheol Jeong ),김경규 ( Kyung Kyu Kim ),김제형 ( Je Hyeong Kim ),권영환 ( Young Hwan Kwan ),이승룡 ( Sung Yong Lee ),이소라 ( So Ra Lee ),조현득 ( Hyun Deuk Cho ),이신형 ( Sin Hyung Lee ),심재 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.46 No.3