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외부 방사선 치료 조사후 재발한 기관지내 악성종양에서 고선량율 근접조사치료(High Dose Rate Brachytherapy)의 효과
조재연 ( Jae Youn Cho ),인광호 ( Kwang Ho In ),서정경 ( Jung Kyung Suh ),강세용 ( Sea Yong Kang ),심재정 ( Jae Jeong Shim ),강경호 ( Kyung Ho Kang ),김광택 ( Kwang Taek Kim ),김철용 ( Cheol Yong Kim ),유세화 ( Se Hwa Yoo ) 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.1
실험견의 급성 저산소성 폐고혈압증에서 K+ Channel 의 역할
조재연(Jae Youn Cho),박상면(Sang Myun Park),박희남(Hee Nam Park),이진구(Jin Goo Lee),심재정(Jae Jeong Shim),인광호(Kwang Ho In),강경호(Kyung Ho Kang),유세화(Se Hwa Yoo) 대한내과학회 1996 대한내과학회지 Vol.50 No.3
N/A Objectives: Numerous studies about mediators in acute hypoxic process have been done. These studies revealed that endothelium derived relaxing factor(EDRF, known as nitric oxide) contributed greatly to the pathogenesis of hypoxic pulmonary hypertension and endothelium derived hyperpolarizing factor(EDHF) regulated the tone of vascular smooth muscle. EDHE is known to open K+ channel, hyperpolarizes vascular smooth muscle cells, closes voltage-dependent Ca++ channel and finally relaxes vascular smooth muscle. Some studies revealed that acute hypoxic pulmonary hypertension was developed by inhibition of EDRF &EDHF. To investigate the role of K+ channel in pulmonary hypertension during acute hypoxia, we measured changes of hemodynamic parameters in experimental dogs after adding glibenclamide(K+ channel blocker), methylene blue(S-guanylate cyclase inhibitor), L-NNA(NO synthase inhibitor) and nicorandil(K+ channel opener and S-guanylate cyclase activator). Methods: Six dogs were anesthetized with thiopental sodium and mechanically ventilated with Harvard volume-cycled animal ventilator. Venous and arterial catheters were placed in the limb vein for infusion and femora} artery to measure systemic arterial pressure. Swan-Ganz catheter was inserted via right internal jugular vein for measuring pulmonary arterial pressure, pulmonary capillary wedge pressure asnd cardiac output. We measured the influence of glibenclamide (3mg/kg). methylene blue(lmg/kg), L-NNA (30mg/kg) and nicorandil(300μg/kg) on the changes of hemodynamic parameters during normoxia and hypoxia. Results: The infusion of nicorandil did not affect mean pulmonary arterial pressure during normoxia and significantly inhibited the increase of mean pulmonary arterial pressure during hypoxia. Glibenclamide did not change mean pulmonary arterial pressure during normoxia, but significantly augmented the increase of mean pulmonary arterial pressure during hypoxia. Methylene blue infusion did not affect mean pulmonary arterial pressure during normoxia, but moderately augmented the increase of mean pulmonary arterial pressure during hypoxia. The infusion of L-NNA did not affect mean pulmonary arterial pressure during normoxia and augmented the increase of mean pulmonary arterial pressure singnificantly during hypoxia, The increase of pulmonary arterial pressure induced by glibenclamide, methylene blue, and L-NNA, under hypoxic state was inhibited by nicorandil. Conclusion: Glibenclamide (K channel blocker) did not affect the mean pulmonary arterial pressure in normoxic state, but augmented the pulmonary hypertension during hypoxia and this effect was inhibited by nicorandil. It is suggested that K+ channel contributes to pulmonary hypertension developed during hypoxia, and the depressive effect of nicorandil seems to be attributable to its dual actions as a K' channel opener and an activator of S-guanylate cyclase.
원저 : 기도 이중 양압(BiPAP)을 이용한 비강 간헐 양압환기의 임상적 적용
조재연 ( Jeo Youn Cho ),이상엽 ( Sang Youb Lee ),이상화 ( Sang Hwa Lee ),박상면 ( Sang Myun Park ),서정경 ( Jung Kyung Suh ),심재정 ( Jae Jeong Shim ),인광호 ( Kwang Ho In ),강경호 ( Kyung Ho Kang ),유세화 ( Se Hwa Yoo ) 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.5
기관지 천식 환자에서 천식 증상의 정도에 따른 β2 교감신경 수용체의 유전자 다형성
심재정 ( Jae Jeong Shim ),김제형 ( Jei Hyung Kim ),이승룡 ( Seung Yong Lee ),권영환 ( Young Hwan Kwan ),이소라 ( So Ra Lee ),이상엽 ( Sang Youb Lee ),강세용 ( Se Yong Kang ),강용구 ( Yong Koo Kang ),조재연 ( Jae Youn Cho ),인광호 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.1
백서의 기도 신경성 염증에서 산화질소 합성효소(Nitric Oxide Synthase)의 역할과 분포
심재정 ( Jae Jeong Shim ),이상엽 ( Sang Yub Lee ),이상화 ( Sang Hwa Lee ),서정경 ( Jung Kyung Suh ),김철환 ( Chul Hwan Kim ),조재연 ( Jae Youn Cho ),인광호 ( Kwang Ho In ),유세화 ( Seo Hwa Yoo ),강경호 ( Kyung Ho Kang ) 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.3
만성 기침 환자에서 기관지와 흉곽외 기도의 Methacholine 유발검사의 의의
심재정 ( Jae Jeong Shim ),김제형 ( Je Hyeong Kim ),이승룡 ( Sung Yong Lee ),권영환 ( Young Hwan Kwan ),이소라 ( So Ra Lee ),이상엽 ( Sang Yeub Lee ),이상화,서정경 ( Jung Kyung Suh ),조재연 ( Jae Youn Cho ),인광호 ( Kwang Ho In ),유 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.4
기관과 기관지를 침범한 재발성 다발성 연골염 (Relapsing Polychondritis)
이상엽 ( Sang Yeub Lee ),조재연 ( Jae Youn Cho ),이소라 ( So La Lee ),이상화 ( Sang Hwa Lee ),서정경 ( Jung Kyung Suh ),심재정 ( Jae Jeong Shim ),송관규 ( Gwan Gyu Song ),인광호 ( Kwang Ho In ),강경호 ( Kyung Ho Kang ),유세화 ( Se 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.4