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이선구(Seon-Gu LEE) 프랑스학회 2018 프랑스학연구 Vol.0 No.84
Dans l œuvre d Anatole France, nous avons trouvé un passage des Entretiens de Confucius, et nous avons pu déceler ailleurs une coloration bouddhique. Confucius veut nous éclairer aussi sur l ignorance fatale de l homme. Le Bouddha sur les douleurs inéluctables qui sont attachées à la condition humaine. Confucius fait allusion au Jen , qui signifie à la fois parfaite vertu , générosité , magnanimité , humanité , bienveillance . Le bouddhisme se réfère à la compassion et à l harmonie. Quant à notre écrivain, il s en tient au comprendre . Entre ces trois attitudes, des traits communs peuvent ê̂tre dégagés : l homme doit dans tous les cas reconnaî̂tre sa limite, accepter constructivement sa condition : comprendre , chez Anatole France, c est aussi se résigner sereinement à ne pas avoir de désirs téméraires comme l enseigne aussi le bouddhisme. En un sens, on peut avancer que les idées, ou plutô̂t les manières de penser et de comprendre d Anatole France, dépassent ces différences qui sont supposées, trop souvent a priori, séparer les mentalités ou les cultures orientales et occidentales. Il n est pas impossible et il est mê̂me très légitime de rapprocher l esprit modéré d Anatole France du Chemin du Milieu du Bouddha et de la modération confucianiste. Anatole France nous y invite lui-mê̂me. Ce qui émane de ses œuvres, c est la force et l attraction d un scepticisme non nihiliste, et devenu activement capable de comprendre . L esprit modéré d Anatole France peut se révéler aujourd hui encore un véritable foyer d énergie créatrice pour nous, ses lecteurs, comme il le faut pour lui, dans l élaboration de son œuvre. Il ne s agit pas exactement ou pas seulement d une philosophie, mais d une sagesse, et qui peut se transmettre comme telle.
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아로니아를 첨가한 고기능성 스펠트 밀가루 식빵의 기호도 분석
이선구(Seon-gu Lee) 한국조리학회 2017 한국조리학회지 Vol.23 No.2
아로니아는 항산화 성분을 풍부하게 함유하고 있는 슈퍼베리로서 그 영양학적 가치로 인해 많은 관심과 연구가 이루어지고 있다. 본 연구에서는 스펠트 밀가루에 아로니아를 첨가하여 나타나는 가공적성을 pH와 발효팽창율을 중심으로 측정하였으며, 일반인을 대상으로 아로니아 첨가에 따른 기호도를 조사하였다. 산도측정 결과, 아로니아 첨가량이 증가함에 따라 pH 값이 낮아지는 경향이 나타났다. 발효팽창률에 있어서 아로니아를 첨가한 반죽의 부피는 아로니아를 첨가하지 않은 경우보다 약간 작은 것으로 측정되었다. 아로니아를 첨가한 빵의 기호도 조사 결과, 아로니아가 3% 첨가되었을 때는 맛에서 가장 많은 기호도가 나타났다. 색깔과 향기 그리고 전반적 호감도에서는 아로니아가 6% 첨가되었을 때 가장 많은 기호도가 나타났다. 이러한 결과를 토대로 스펠트 밀가루 식빵에 대한 아로니아 성분의 적정 배합비율은 6%로 선정되었다. Aronia is a superberry that contains antioxidants. Due to its nutritional value, it has received much attention and has been widely researched. In this study, the proportion of aronia powder applied to spelt wheat flour was measured with the pH ratio of the additive and respondents’ preference was examined for the preferred addition to the additive population. As a result of the acidity measurement, the pH value tended to decrease as the amount of aronia powder was increased. As for the fermentation expansion rate, the volume of the dough added with aronia powder was measured to be slightly smaller than that without addition of aronia powder. Preference of breads with aronia powder added showed higher preference when 6% was added compared to when 3% of aronia powder was added. As a result of preference survey of breads containing aronia powder, the most preference was given to taste when 3% of aronia powder was added. Color, fragrance, and overall acceptance were the most preferred when 6% of aronia powder was added. Based on these results, the optimal mixing ratio of aronia powder to spelt flour bread was selected to be 6% of aronia powder.
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최근 11년간(2006∼2016) 경기 동남부 지역의 주요 피부악성종양과 피부암전구증에 관한 통계적 고찰
이선구 ( Seon Gu Lee ),이희정 ( Hee Jung Lee ),윤문수 ( Moon Soo Yoon ),김동현 ( Dong Hyun Kim ) 대한피부과학회 2019 대한피부과학회지 Vol.57 No.1
Background: The incidence of cutaneous malignant tumors and premalignant lesions has recently increased worldwide. However, studies investigating the incidence and clinical manifestations of cutaneous malignant tumors and premalignant lesions in Korea are rare, especially in southeastern Gyeonggi-do Province. Objective: To analyze the recent trends in the incidence of cutaneous malignant tumors and premalignant lesions in southeastern Gyeonggi-do Province. Methods: We retrospectively reviewed 451 cases of cutaneous malignant tumors and 455 cases of premalignant lesions from 2006 to 2016. Results: The average annual incidence rates of cutaneous malignant tumors and premalignant lesions among the total number of outpatients was 0.84% and 0.85%, respectively, and both these rates increased significantly over time. Basal cell carcinoma was most commonly diagnosed cutaneous malignant tumor (50.8%), followed by squamous cell carcinoma (24.6%), malignant melanoma (8.2%), and metastatic carcinoma (5.1%). The most common premalignant lesion was actinic keratosis (60.0%). The mean age of the patients with cutaneous malignant tumors and premalignant lesions was 68.8 years and 70.8 years, respectively. The ratio of male to female patients was 1:1.19 for cutaneous malignant tumors and 1:2.01 for premalignant lesions. The face was the most common site for both cutaneous malignant tumors and premalignant lesions (at 71.9% and 75.8%, respectively). Conclusion: This retrospective study provided data about the incidence and clinical patterns of cutaneous malignant tumors and premalignant lesions among patients in southeastern Gyeonggi-do Province. (Korean J Dermatol 2019;57(1):1∼8)
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황선구(Seon Gu Hwang),양안나(Anna Yang),김수정(Soo Jung Kim),김민기(Min Kee Kim),김성수(Sung Soo Kim),오현정(Hyun Jung Oh),이정대(Jung Dae Lee),이은주(Eun Ju Lee),남궁우(Kung-Woo Nam),한만덕(Man-Deuk Han) 한국생명과학회 2014 생명과학회지 Vol.24 No.5
HAase는 신체의 연골, 피부, 눈의 초자체 등에 포함된 고분자 다당류의 HA를 분해하는 효소로서 상처나 염증질환 시 활성화되어 염증, 알레르기 유발과 관련된 효소이다. 본 연구는 500종 식물에서 각 종당 한 식물체로부터 한 천연물의 메탄올 추출물(500추출물)을 이용하여 생물학적으로 기능이 다양하고 산업적으로 활용 가능성이 많은 HAase 저해제를 검색하였다. 그 결과 HAase 저해효과가 가장 우수한 천연물 추출물은 때죽나무 줄기 추출물 57.28%, 매화말발도리 줄기 추출물 53.50%의 저해효과를 나타내었다. 이 같은 추출물들의 농도 별 저해효과를 확인한 결과 농도 의존적으로 저해율이 증가하였다. 이 같은 결과로 볼 때 때죽나무, 매화말발도리 추출물은 HAase 효소의 저해효과가 우수하여 향후 HA 분해와 관련된 항염증 및 항 알레르기 연구에 이용될 수 있다. Mammalian hyaluronidases (HAase, EC 3.2.1.35) are a family of enzymes that hydrolyse N-acetyl-Dglucosamine (1-4) glycosidic bonds in hyaluronic acid, which is found in skin, cartilage, and the vitreous body. Although HAase is generally present in an inactive form within subcellular lysosomes, it is released in an active form in some types of inflammation and tissue injuries, thereby contributing to the inflammatory response. The HAase inhibitory activity of 500 methanolic extracts of 500 species from medicinal plants was screened using a Morgan microplate assay. The viscosity of the hyaluronic acid was measured with an Ubbelohde viscometer. Three MeOH extracts inhibited more than 50% of HAase activity at a concentration of 2 mg/ml. HAase inhibitory rates (%) of three species of medicinal plant extracts, Styrax japonica, Deutzia coreana, and Osmanthus insularis were 57.28%, 53.50%, and 53.19%, respectively. The rate of HAase inhibition of the extracts was dose dependent. In the HAase inhibitory assay using the Ubbelohde viscometer, the results were in good agreement with the results from the Morgan assay. The results suggest that HAase inhibitory compounds extracted from the stem of S. japonica, D. coreana, and O. insularis might be multifunctional and prevent the degradation of hyaluronic acid and the induction of allergic reactions and inflammation.
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