99mTc - DTPA 및 Gamma Scintillation Camera를 이용한 사구체 여과율의 측정

이민재(Min Jae Lee),최재걸(Jae Gol Choe),백세현(Sei Hyun Baik),서원혁(Won Hyuck Suh) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A The radioisotopic measurement of glomerular filtration rate (GFR) has required analysis of serial blood or urine samples over several hours, and does not allow measurement of separate renal function unless separate catherterization of individual ureters is done. Gates described isotopic method for the measurement of global and unilateral GFR based on the determination by scintillation camera of the fraction of the injected dose of Tc-99m-diethylenetriaminepentaacetic acid (DTPA) present in the kidneys 2-3 minutes after its administration.We calculated GFR according to Gates' method in 58 adult patients with various levels of global renal function using Tc-99m DTPA and validated this technique by correlation with 24 hour creatinine clearance. A good correlation was observed between 24 hour creatinine clearance and GFR calculated by Gates' formula, with an r value of 0.91 (p〈0.01). We concluded that determination of GFR according to the Gates' formula allows good and reproducible prediction of GFR with great rapidity and simplicity rendering this technique suitable for clinical practice.

식도 운동 질환에 있어서 동위원소 식도 통과 검사의 의의

이민재(Min Jae Lee),최재걸(Jae Gol Choe),송치욱(Chi Wook Song) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2

N/A Esophageal motility was evaluated from the analysis of 10 consecutive swallows using liquid bolus containing 0.5 mCi of Tc-99m tin colloid. We have reviewed our experience of esophageal transit study in the 20 normal volunteers and 55 patients with dysphagia that was not related to mechanical obstruction. The purpose of this study is to measure the esophageal transit in normal subjects and in patients with various esophageal motility disorders. The overall sensitivity and specificity of radionuclide esophageal transit study in detecting esophageal motor abnormality were compared with manometric results as a gold standard, which were 80% and 100% respectively. Radionuclide transit study is a safe, rapid, noninvasive test and suitable as a screening test for esophageal motor disorders.

유동식 및 고형식을 이용한 동위원소 식도통과검사의 임상적 의의에 대한 연구

이민재(Min Jae Lee),최재걸(Jae Gol Choe),서원혁(Won Hyuck Suh),송치욱(Chi Wook Song),현진해(Jin Hai Hyun) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1

N/A The author performed radionuclide esophageal transit studies(RETS) with liquid and solid boluses using the same day protocol in 90 normal controls and 164 patients with various primary esophalgeal motility disorders who were diagnosed by manometric criteria and clinical courses. The authors calculated mean esophageal transit time(MTT) and mean residual retention(MRR) in each of the liquid and solid studies, and classified time-activity curve(TAC) patterns. The normal criteria of RETS with liquid bolus were MTT〈24 sec, MRR〈9%, and the TAC pattern that showed rapid declining slope and flat low residual(Type 1). The normal criteria of RETS with solid bolus were MTT〈35 sec, MRR〈9% and TAC of type 1. With these normal criteria, the sensitivity and the specificity of the liquid study were 62.2% and 97.8%, respectively. The sensitivity increased to 75.4% with the solid study. The author also found that the RETS was highly reproducible. The achalasia typically shoewed no effective emptying of both liquid and solid boluses during the whole study period, and was well differentiated by its extremely long transit time and high retention from the other motility disorders. The diffuse esophageal spasm(DES) and nonspecific esophageal motility disorder(NEMD) showed intermediate delay in tranit time and increased retention. In the groups of hypertensive lower esophageal sphincter(LES), hypotensive LES and nutcracker, there noted no significant difference with the normal control group in terms of MTT and MRR. The DES and NEMD could be more easily identified by solid studies that showed more marked delay in MTT and increased MRR as compared with the liquid study. In conclusion, esophageal scintigraphy is a safe, noninvasive and physiologic method for the evaluation of esophageal emptying.

동위원소 뇌혈관 촬영술을 이용한 뇌사의 판정

최재걸,이민재 ( Jae Gol Choe,Min Jae Lee ) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.2

식도운동질환과 방사성 동위원소 식도통과시간 및 통과 양상에 관한 연구

김혜랑(Hye Rang Kim),송치욱(Chi Wook song),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun),최재걸(Jae Gol Choe),이민재(Min Jae Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.5

N/A Background/Aims: Radionuclide esophageal transit study(RETS) has been proposed as a screening test for esophagea] motility disorders. However, ]ittle attention was paid to the esophageal transit patterns in various esophageal motility disorders. In the present study, we have compared the results from esophageal manometry and transit studies. Methods: Ninety six pantients with esopha- geal symptoms and 20 subjects without any known esophageal symptoms or disease were included. The results of RETS were divided into the following 3 patterns: normodynamic(ETT --15 sec), hypodynamic(lS ETT:- 300 sec). Within the group of patients with the hyp<xlynamic patterns, the transit curves were divided into 3 types: slope type, staircase type and another type. Results: Esophageal transit pattern in normal controls was smooth uninterrupted transit of bolus down the esophagus with mean ElT of 8.5 L6.5 seconds. Esophageal transit patterns in patients with es<ophageal symptoms were adynamic pattern(]2 achalasia, 1 seleroderna esophagus, I MEMD), normodynamic pattern(l9 NEMD), HLES(l diffuse esophageal spasm nutcracker esophagus), hypodynamic-staircase type(6 diffuse esophageal spasm, 3 NEMD). Hypodynamic-slope type(l9 NEMD), 3 HLES, 2 normal, 1 diffuse esophageal spasm, 1 nutcracker esophagus) and hypodyna- mic-other type(5 NEMD), 2, nutcracker esophagus, l. diffuse esophageal spasm, J. scleroderma esophagus, 1 normal). Conclusions: Normal subjects exhibited normodynamic patterns, whereas most of the achalasia patterns exhibited adynamic patterns and patients with diffuse esophageal spasm exhibited the various patterns of esophageal which suggest that this group has heterogenous motility abnormalities. (Korean J Gastroenterol 1995;27: 499-508)

방사성동위원소 표지 단일클론항 GGT 항체를 이용한 간 질환에 대한 연구

함수연,최재걸,이민재,정규병,김명곤,류총근 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.3

This study was designed to investigate whether radioisotope labeled tissue-specific monoclonal anti-γ Glutamyltransferase (GGT) antibodies can be used for the scintigraphic localization of abnormal hepatic tissue of rat. Three monoclonal anti-GGT antibodies (GGT MAb-1, 5, 6) were biochemically purified from the ascites of BALB/c mice which were injected hybridomas secreting monoclonal antibody to a 7.17 mg of immunoglobulin per ml of protein and the mean immunoglobulin amount was 4.98 mg. Then I-131 was incorporated to GGT MAbs by lodogen method with an average labeling efficiency of 77.4% (GGT MAb), and 86.8% (GGT PAb) and in case of Tc-99m by sodium dodesylsulfate, they were 57.7% (GGT MAb), and 77.6% (GGT PAb) respectively. In vitro assay revealed that there was a significant correlation between the result of immunohistochemistry and that of tissue autoradiography according to the type of tissue and monoclonal antibodies in normal heaptic tissue, preneoplastic liver and normal kidney. Modified GGT MAb-1 was specific for the hepatic tissue of preneoplastic liver, GGT MAb-5 for the normal liver, and GGT MAb-6 for the normal kidney. In vivo assay revealed selective localization of radioactivity over tissue specific GGT distributed organs of Wister rat by immunoscintigraphy and tissue γ-counting. In conclusion, radioisotope labeled anti-GGT antibodies might be used for both in vitro and in vivo assays and could be used for the localization of musine hepatic disorders by immunoscintigraphy.