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이도남,권기학,김영미,조현준,이선화 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.102 No.-
Metal-organic frameworks (MOFs) that include bioactive metals may exhibit activity against variousmicrobes through metal–ligand bond cleavage to release metal ions or ligands into the media. However, controlled release over an extended time is required to avoid toxicity due to excess metal ionsfor successful clinical applications. Recently, copper-based MOFs (Cu-MOFs), which showed sustainedrelease capability, porosity, and structural flexibility, exhibited antibacterial properties. Herein, towardthe development of regenerative biomedical applications, we immobilized a robust Cu-MOF containingglutarate and 1,2-bis(4-pyridyl)ethylene ligands within biocompatible polydimethylsiloxane (PDMS)via simple hydrosilylation at 25 C. The PDMS-immobilized Cu-MOF (PDMS@Cu-MOF) exhibitedconcentration-dependent antibacterial activities against five bacterial strains: Escherichia coli,Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and methicillin-resistantStaphylococcus aureus. Furthermore, PDMS@Cu-MOF maintained the physical and thermal properties ofPDMS and showed low cytotoxicity toward mouse embryonic fibroblasts. Owing to its antibacterial propertiesand low cytotoxicity, PDMS@Cu-MOF exhibited potential for medicinal applications, such asimplants, skin disease treatment, wound healing, and drug delivery.