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암의 종류 및 증상에 따른 삶의 질 평가 척도에 관한 연구 현황 분석
이남헌,조정효,손창규,유화승,이연월,윤담희,이종훈,방선휘,조종관,Lee, Nam-Heon,Cho, Jung-Hyo,Son, Chang-Gue,Yoo, Hwa-Seung,Lee, Yeon-Weol,Yoon, Dam-Hee,Lee, Jong-Hoon,Bang, Sun-Hwi,Cho, Chong-Kwan 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
Objectives : The objective of this study is to analyze what quality of life(QOL) scales are frequently used in cancer patients and lay a cornerstone to develop new QOL scales adequate for oriental medical anti-cancer treatment in the future. Methods : We searched 151 articles concerned with 'QOL and scale and cancer' from PubMed and classified them according to periods. nations. cancer types and symptoms. Results: 138 articles(91%) were published after 1996. 65 articles(43%) were published in USA. For breast. lung, prostate. esophageal cancer and melanoma. European Organization for Research and Treatment of Cancer-quiality of life questionaire(EORTC-QLQ) was used most frequently to evaluate quality of life. Functional Assessment of Cancer Treatment(FACT) for bladder cancer. Hospital Anxiety and Depression Scale(HADS) for colorectal cancer and of Washington Quality of Life questionnaire(UW-QOL) for Head & Neck cancer were used repeatedly. And for the patients with the symptoms such as bone marrow depression. depression. pain. dyspnea. nausea & vomiting and voice change. the investigators used EORTC-QLQ mainly to evaluate QOL. FACT-An(anemia) for anemia. FACT-BMT(bone marrow transplant) for bone marrow depression were applicated generally. Conclusions It is anticipated that further investigations will be performed to develop adequate QOL scales for oriental medical anti-cancer therapy.
도관적입법(導管滴入法)으로 호전된 장폐쇄증(腸閉鎖症) 환자 치험 2례 보고
이남헌,윤담희,이지영,채은영,유화승,조정효,이연월,손창규,조종관,Lee, Nam-Heon,Yoon, Dam-Hee,Lee, Ji-Young,Chae, Eun-Young,Yoo, Hwa-Seung,Cho, Jung-Hyo,Lee, Yeon-Weol,Son, Chang-Gue,Cho, Chong-Kwan 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4
This study was designed to evaluate the effects of retention enema therapy on patients with ileus. We retrospectively analyzed the medical records of two patients with ileus whose main symptoms were nausea, vomiting, constipation and abdominal pain. They were treated with retention enema therapy. After treatment, improvement was seen in nausea, vomiting, constipation and abdominal pain. The results of this study suggests that retention enema therapy is effective for the treatment of ileus.
이남헌,윤담희,유화승,조정효,손창규,이연월,조종관,Lee, Nam-Heon,Yoon, Dam-Hee,Yoo, Hwa-Seung,Cho, Jung-Hyo,Son, Chang-Gue,Lee, Yeon-Weol,Cho, Chong-Kwan The Society of Internal Korean Medicine 2005 大韓韓方內科學會誌 Vol.26 No.4
목적 : 본 연구는 100명의 암환자를 대상으로 항암단의 항혈관형성 효과를 측정하기 위하여 고안되었다. 방법 : 100명의 암환자 전체의 치료전후의 VEGF, bFGF 및 혈소판 수치의 변화량을 측정하였고, 병기, 삶의 질 및 암종별로 환자를 나누어 각각의 치료전후의 VEGF, bFGF 및 혈소판 수치의 변화량을 측정하여 통계적 유의성을 살펴보았다. 결과 : 항암단으로 치료한 암환자의 bFGF 수치는 치료전 후 통계적으로 유의성 있게 감소하였다. 특히 유방암 환자에서 bFGF 수치의 감소가 눈에 띄었다. 비록 통계적으로 유의하지는 않았지만 VEGF수치도 항암단으로 치료 후 다소 감소하는 경향을 보였다. 결론 : 따라서 항암단이 암환자 치료에 있어 항혈관형성 약물로써 작용한다고 추론할 수 있다.
온천이 소아의 체성분과 자율 신경 기능에 미치는 영향에 관한 연구
조민서,이남헌,한재경,Jo, Min-Seo,Lee, Nam-Heon,Han, Jae-Kyung 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.3
Objectives: This study was performed to investigate the effect of hot spring therapy on children weight, body composition and heart rate variability. Methods: The study was carried out from 30 children who visited the spa from August 1, 2011 to August 31, 2011. We measured the change of weight, body composition, and heart rate variability after hot spring therapy for an hour per day. Results: The subject was consisted of 13 boys and 17 girls. This study revealed that their weight got lost from a hot spring therapy, which was statistically significant. Their body mass index(BMI) was decreased in from a hot spring therapy, which was not statistically significant. Total body water, muscle, protein, and mineral were decreased from a hot spring therapy, which was statistically significant. We measured HRV(heart rate variability) before and after the hot spring therapy. The mean HRT was increased, which was statistically insignificant. SDNN(standard deviation of the NN interval) and RMSSD(square root of the mean of the sum of the square of differences) were not different before and after the hot spring therapy. ln TP was decreased insignificantly. ln VLF was not affected before and after hot spring therapy. ln LF and ln HF was decreased, LF norm was increased, and HF norm was decreased, which were not statistically significant. Also, LF/HF ratio was increased insignificantly. Conclusions: From these results, we concluded that the weight, total body water, muscle, protein, and mineral got lost from the hot spring therapy. However, the HRV was not affected from the hot spring therapy.
윤해창,손창규,이남헌,조정효,Yoon, Hae-chang,Son, Chang-gue,Lee, Nam-heon,Cho, Jung-hyo 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4
Objective: The aim of this study was to establish the developmental history of hospice palliative care (HPC) with Korean medicine (KM). Methods: We compared the developmental history of HPC in Korea with that of Britain, the United States, Taiwan, Japan, and China. The articles in English or Korean published until Feb. 2017 were searched using 'Hospice' or 'Palliative care' with the name of each nation in the PubMed, MEDLINE, ScienceDirect, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases for foreign articles and OASIS (Oriental Medicine Advanced Searching Integrated System) for domestic articles. Books and gray literature were searched on the same databases and websites of the Ministry of Health and Welfare and related organizations in each country. Results: Modern palliative care began with the hospice movement led by Dr. Cicely Saunders. HPC in Korea started earlier than in other countries but it took considerable time for social consensus, so Korean policies have only been published recently. In this process, KM was excluded from HPC. For this reason, western medicine in Korea does not fully accept the spirit of HPC, the government does not take an aggressive stance with KM, and the institutes of KM do not have any interest in HPC. The World Health Organization recommends the establishment of policies and programs connected with a country's own health care system. In 2015, the Korean government made the third comprehensive plan for the development of KM. It included critical pathway guidelines about cancer-related fatigue and anorexia. More effort is required to set up HPC than other care types because Korea has two medical systems. Conclusions: Each nation has been trying to improve systems of HPC. We need to overcome the problems and bring out the best by making our own model of HPC with KM.
곽향(藿香) 추출물(抽出物)이 장운동(腸運動)에 미치는 영향(影響)
이정수,손창규,조정효,신장우,유화승,이연월,이남헌,윤담희,조종관,Lee, Jung-Soo,Son, Chang-Gue,Cho, Jung-Hyo,Shin, Jang-Woo,Yoo, Hwa-Seung,Lee, Yeon-Weol,Lee, Nam-Heon,Yun, Dam-Hee,Cho, Chong-Kwan 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4
Objectives : 본 연구는 암환자의 위장관 기능장애를 개선시킬수 있는 보다 효과적인 약물개발의 일환으로 곽향 추출물의 장운동에 미치는 영향을 평가하기 위해 수행되어졌다. Methods : 생리적인 상태에서 곽향추출물이 장운동에 미치는 영향을 알아보기 위해 장운동촉진제인 carbachol과 곽향추출물을 실험쥐들에게 투여후 15분후 charcoal meal을 먹여서 charcoal meal의 소장내 통과 정도를 비교 측정하였다. 또, loperamide, scopolamine, nicotine으로 장운동을 억제시켜 놓은 실험쥐들에 15분 간격으로 곽향 추출물과 charcoal meal을 먹인 후 역시 charcoal meal의 소장내 통과 정도를 비교 측정하였다. Results : 곽향 추출물은 생리상태에서는 장운동에 영향을 미치지 않았다. 곽향추출물은 loperamide와 scopolamine으로 유발된 장운동 억제상태에 대하여 부분적으로 영향을 끼쳤다. 그러나 nicotine으로 유발된 상태에 대해서는 영항을 끼치지 않았다. Conclusion : 곽향 추출물은 소화관 기능부전 완화에 효과적으로 작용하는 천연물이라 추론할 수 있다.
Lipid-lowering Effect of Chunggantang in Poloxamer-407 induced Hyperlipidemia Model in Rat
박종학,조정효,신장우,이연월,유화승,이남헌,윤담희,조종관,손창규,Park, Hong-Hak,Cho, Jung-Hyo,Shin, Jang-Woo,Lee, Yeon-Weol,Yoo, Hwa-Seung,Lee, Nam-Heon,Yun, Dam-Hee,Cho, Chong-Kwan,Son, Chang-Gue The Society of Internal Korean Medicine 2005 大韓韓方內科學會誌 Vol.26 No.4
연구목적: 본 연구는 Poloxamer-407로 유발시킨 고지혈증에 대한 청간탕의 효과를 알아보기 위해 수행되어졌다. 실험방법: Poloxamer-407로 쥐에 고지혈증을 유발시킨후 청간탕과 Lipidil을 경구 투여하여 혈청 cholesterol, 고밀도 지단백, 중성지질을 측정하였으며, 지질대사와 관련된 ACAT, DGAT, $CYP7{\alpha}H$, LDL receptor의 gene expression을 RT-PCR를 통해 비교 분석하였다. 실험결과: 청간탕 투여군은 혈청 콜레스테롤을 각각 32% 와 65% (p<0.05)로, 혈청 중성지방을 각각 21% 와 51% (p<0.05)로 감소시켰다. 또한, 청간탕은 LDL 수용체와 $CYP7{\alpha}H$ 유전자 발현을 증가시켰다. 결론: 이상의 연구로부터 우리는 청간탕이 지질의 흡수, 저장을 억제하고 콜레스테롤의 분비를 촉진함으로써 고지혈증에 일정한 효과가 있음을 알 수 있었다.
암 환자에 대한 구법의 치료와 메커니즘에 대한 최신 국내외 연구 현황
윤해창,강지영,김준영,정진용,손창규,이남헌,조정효,Yoon, Hae-chang,Kang, Ji-young,Kim, Jun-young,Joung, Jin-yong,Son, Chang-gue,Lee, Nam-heon,Cho, Jung-hyo 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.3
Objectives This study aims to review and summarize existing evidence on moxibustion treatment for cancer patients. Methods Literature published until May 2015 in international journals were searched on PubMed, CAJ (CNKI-Medicine), NDSL (National discovery for science leaders), Sage Journal, ScienceDirect, Taylor&Francis Online (HSS), and Wiley Interscience (including Blackwell); and articles in Korean journals were searched on Korean Studies Information Service System (KISS), DBPIA, E-Article, KSI e-book, New article, Korea Institute of Science and Technology Information (KISTI), and Kyobo scholar. Results We analyzed 65 relevant studies. The number of studies conducted annually has increased and most are conducted in Korea and China. Moxibustion decreases the side effects of palliative treatment, thereby synergizing with anticancer treatment; it also improves the immune system, reduces tumor factors, and relieves symptoms. The mechanism of moxibustion is multi-fold: thermo, chemo, aero and kinetic. Only the kinetic effect is not significant. It also needs a complement to moxibustion because of harmful smoke. Conclusions Thus, the effect and mechanism of moxibustion in cancer patients was reviewed. There is an unmet need to develop a model of moxibustion and test it based on Korean medicine.