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PCB 가공을 위한 마이크로 엔드밀의 유한 요소 해석 모델에 관한 연구
이경태(Kyung-Tae Lee),홍영선,김진웅,여준철,박재석(Jae-Seuk Park),안성훈(Sung-Hoon Ahn) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
In the present industrial applications, milling is one of highly productive machining processes. Many researches of milling process including FEM analysis have been performed with various materials and conditions. Recently milling of micro scale is needed for more precise electric circuit in electronic products. In this paper, the three-dimensional FEM (Finite Element Method) simulations of micro milling were performed for PCB. Elasto-plastic material model was used in the commercial explicit finite element code, LS-DYNA. From the result, maximum stress was shown near end mill tip. And plastic strain was remained after machining simulation.
당귀와 천궁 및 시호의 병용 경구 투여에서 흰쥐 혈중 Decursinol 농도의 비교 검토
박노정,김남재,이경태,서성훈,Park, Roh-Jeong,Kim, Nam-Jae,Lee, Kyung-Tae,Seo, Seong-Hoon 한국생약학회 2001 생약학회지 Vol.32 No.1
This study was performed to elucidate the influence on the plasma decursinol concentration after administration of combined decursin and Cnidii Rhizoma or decurisin and Bupleuri Radix extracts in comparison with single decursin administration. The identification of decursinol isolated from Angelica gigas was carried out by GC/MS and the concentration of decursinol in the plasma after oral administration was determined by HPLC. The value of area under the plasma concentration (AUC) and the maximal concentration (Cmax) of decursinol after administration of methanol and ether Angelicae Gigantis Radix extract was higher than those of single decursin-treated group. It was also found that the AUC and the Cmax of decursinol after combined administration with decursin and Cnidii Rhizoma were higher than those of decursin administration, whereas those of combined with decursin and Bupleuri Radix was lower. Moreover, the studies were performed with decursinol only or with combined decursinol and Cnidii Rhizoma/Bupleuri Radix, both of combined treatment increased the plasma decursinol concentrations compared with decursinol-treated group in rats. On the basis of these results, it is concluded that co-existing substances or co-administration with other drugs may influence the plasma levels of decurisinol after oral administration.
Costunolide의 백혈병 세포주 U-937에 대한 분화 유도 작용
김주일,이성호,박재훈,박희준,이경태,Kim, Joo-Il,Lee, Sung-Ho,Park, Jae-Hoon,Park, Hee-Joun,Lee, Kyung-Tae 한국생약학회 1999 생약학회지 Vol.30 No.1
The present work was carried out to examine the effect of costunolide on the growth of several cells and characteristics of U-937 human leukemia-derived cell line. Costunolide produced a potent antitumor activity in vitro dependent on concentration against several tumor cells such as P-388, L-1210 leukemia and SNU-5 stomach cancer cells. However, it showed less cytotoxicity on normal cells such as Maccaccus rheus monkey kidney cells (MA-104) up to 200 ${\mu}M$ concentration. An effect of cell differentiation by costunolide was assessed by its ability to reduce nitroblue tetrazolium (NBT), and to induce phagocytosis of latex particles. In order to establish whether costunolide induces U-937 cells to differentiate toward macrophage or granulocyte, esterase activities was measured. Based on these results, we found that costunolide having cytotoxicity on U-937 human leukemia cells was explained through differentiation inducing activity.
박재훈,김종환,김주일,김승조,서성훈,이경태,Park, Jae-Hoon,Kim, Jong-Hwan,Kim, Joo-Il,Kim, Seung-Jo,Seo, Seong-Hoon,Lee, Kyung-Tae 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
This laboratory has recently reported the solubility and in vivo absorption enhancement of diclofenac sodium by ${\beta}-cyclodextrin$ complexation. The acute gastroduodenal mucosa injury provoked by administration of 34 mg/kg and 68 mg/kg of a diclofenac sodium (DS) and equivalent dose of new formulation [diclofenac sodium-beta-cyclodextrin complexation$(DS-{\beta}-CD)$] was evaluated and compared. Microscopic examinations, performed after 18-hrs treatment, demonstrated that $DS-{\beta}-CD$ was less gastrolesive than DS. The drop in gastrophy after a single dose of the assigned drug was considerably greater for DS than for $DS-{\beta}-CD$, which registered similar values to control. Since gastrophy is an expression of the anatomy-functional integrity of the gastric barrier, the results indicate that $DS-{\beta}-CD$ exerts less direct acute damage on the gastric mucosa. Therefore, when administered short-term, $DS-{\beta}-CD$ appears to be less gastrolesive than the standard DS formulation.
디클로페낙나트륨 디클로페낙나트륨과 β - 시클로덱스트린 포접물의 흰쥐 위 점막 손상 비교
박재훈,김종환,김주일,김승조,서성훈,이경태 ( Jae Hoon Park,Jong Hwan Kim,Joo Il Kim,Seung Jo Kim,Seong Hoon Seo,Kyung Tae Lee ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A This laboratory has recently reported the solubility and in vivo absorption enhancement of diclofenac sodium by β-cyclodextrin complexation. The acute gastroduodenal mucosa injury provoked by administration of 34 ㎎/㎏ and 68 ㎎/㎏ of a diclofenac sodium (DS) and equivalent dose of new formulation [diclofenac sodium-beta-cyclodextrin complexation(DS-β-CD)] was evaluated and compared. Microscopic examinations, performed after 18-hrs treatment, demonstrated that DS-β-CD was less gastrolesive than DS. The drop in gastrophy after a single dose of the assigned drug was considerably greater for DS than for DS-β-CD, which registered similar values to control. Since gastrophy is an expression of the anatomy-functional integrity of the gastric barrier, the results indicate that DS-β-CD exerts less direct acute damage on the gastric mucosa. Therefore, when administered short-term, DS-β-CD appears to be less gastrolesive than the standard DS formulation.
타리비드 정(오플록사신 100㎎)에 대한 파비드 정의 생물학적동등성
박완수,조성희,이헌우,임호택,홍성제,서성훈,류재환,이경태 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1
The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jell Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, 23.67±3.12 year in age and 68.50±7.23 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were deter mined using HPLC. Pharmacokinetic parameters such as AUC_(t) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), and C_(max) and untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., log 0.94-log 1.04 and log 0.90-log 1.07 for AUC_(t) and C_(max) respectively). The major parameters. AUC_(t) and C_(max) met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.
당귀와 천궁 및 시호의 병용 경구 투여에서 흰쥐 혈중 Decursinol 농도의 비교 검토
박노정,김남재,이경태,서성훈 경희대학교 경희동서약학연구소 2001 경희약대 논문집 Vol.29 No.-
This study was performed to elucidate the influence on the plasma decursinol concentration after administration of combined decursin and Cnidii Rhizoma or decurisin and Bupleuri Radix extracts in comparison with single decursin administration. The identification of decursinol in the plasma after oral administration was determined by HPLC. The value of area under the plasma concentration (AUC) and the maximal concentration (Cmax) of decursinol after administration of methanol and ether Angelicae Gigantis Radix extract was higher than those of single decursin-treated group. It was also found that the AUC and the Cmax of decursinol after combined administration with decursin and Cnidii Rhizoma were higher than those of decursin administration, whereas those of combined with decursin and Bupleuri Radix was lower. Moreover, the studies were performed with decursinol only or with combined decursinol and Cnidii Rhizoma/Bupleuri Radix, both of combined treatment increased the plasma decursinol concentrations compared with decursinol-treated group in rats. On the basis of these results, it is concluded that co-existing substances or co-administration with other drugs may influence the plasma levels of decurisinol after oral administration.
당귀와 천궁 및 시호의 병용 경구 투여에서 흰쥐 혈중 Decursinol 농도의 비교 검토
박노정,김남재,이경태,서성훈 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
This study was performed to elucidate the influence on the plasma decursinol concentration after administration of combined decursin and Cnidii Rhizoma or decurisin and Bupleuri Radix extracts in comparison with single decursin admimistration. The identification of decursional isolated from Angelica gigas was carried out by GC/MS and the concentration of decursinol in the plasma after oral administration was determined by HPLC. The value of area under the plasma concentration (AUC) and the maximal concentration (Cmas) of decursinol after administration of methanol and ether Angelicae Gigantis Radix extract was higher than those of single decursin-treated group. It was also found that the AUC and the Cmax of decursional after combined administration with decursin and Cnidii Rhizoma were higher than those of decursin administration, whereas those of combined with decursin and Bupleuri Radix was lower. Moreover, the studies were performed with decursinol only or with combined decursinol and Cnidii Rhizoma/Bupleuri Radix, both of combined treatment increased the plasma decursinol concentrations compared with decursinol-treated group in rats. On the basis of these results, it is concluded that co-existing substances or co-administration with other drugs may influence the plasma levels of decurisinol after oral administration.
LEE, Min-Goo,LEE, Kyung-Tae,CHI, Sung-Gil,PARK, Jae-Hoon 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
Consunolide is an active compound isolated from the root of Saussurea lappa Clarks, a Chinese medicinal herb, and is considered a therapeutic candidate for various types of cancers. Nevertheless, the pharmacological pathways of costunolide are still unknown. In this study, we investigate the effects of costunolide on the induction of apoptosis in HL-60 human leukemia cells and its putative pathways of action. Using apoptosis analysis, measurement of reactive oxygen species (ROS), and assessment of mitochondrial membrane potentials, we show that costunolide is a potent inducer of apoptosis, and facilitates its activity via ROS generation, thereby inducing mitochondrial permeability transition (MPT) and cytochrome c release to the cytosol. ROS production, mitochondrial alteration, and subsequent apoptotic cell death in costunolide-treated cells were blocked by the antioxidant N-acetylcystein (NAC). Cyclosporin A, a permeability transition inhibitor, also inhibited mitochondrial permeability transition and apoptosis. Our data indicate that costunolide induces the ROS-mediated mitochondrial permeability transition and resultant cytochrome c release. This is the first report on the mechanism of the anticancer effect of costunolide.