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알레르기성 비염에 대한 Ketotifen(Zaditen)의 임상적 효과
송계원,박문흠,서장수,김용대,은선진 영남대학교 의과대학 1990 Yeungnam University Journal of Medicine Vol.7 No.1
저자들은 1988년 5월 1일부터 12월 31일까지 영남대학교 의과대학 부속병원 이비인후과에 내원한 알레르기성 비염환자 39명을 대상으로 Ketotifen 1일 투 2㎎씩 8주동안 투여한 뒤 재채기 발작, 수성비루, 비폐색, 비강내 이학적 소견, 효과 발현시기, 부작용 등을 관찰하여 다음과 같은 결과를 얻었다. 1) 전반적 개선도는 개선 이상이 66.7%, 약간 개선 이상이 87.2%로 유의한 증상의 호전이 있었다. 2) 증상별로 재채기 발작은 73.5%, 수성비루 71%, 비폐색 58%에서 증상의 호전이 있었으며 재채기 발작과 수성비루에 대해 더욱 효과적이었다. 3) 증상의 발현시기는 1주이내 35.7%, 2주이내 53.8%, 3주이내 66.7%, 4주이내 74.4%, 8주이내 87.2%로 나타냈다. 4) 비점막 소견의 유의한 호전은 없었다. 5) 부작용은 1례에서 경한 복통과 설사가 있어서 투약을 중지하였다. 이상과 같이 Ketotifen은 알레르기성 비염의 치료에 효과적이며 비교적 안전하게 사용할 수 있는 약제라고 생각할 수 있다. Ketotifen, a benzocycloheptathiophene, has an orally effective antiallergic as well as antihistaminic properties. In pervious studies, Ketotifen has shown encouraging results in patient with allergic rhinitis, either perennial or seasonal. 39 patients with allergic rhinitis had been treated with Ketotifen 1 mg twice daily for 8 weeks. And we obtained following results. 1) The efficacy rate in sneezing attack was 73.5%, in nasal discharge 71%, in nasal obstruction 58%. 2) Some improvements in at least one of three major symptoms were noted within 1 week in 30.7%, within 2 weeks in 55.8%, within 3 weeks in 66.7%, within 8 weeks in 87.2%. 3) Physical findings such as colour, swelling of turbinate, character of rhinorrhea were not improved singnificantly. 4) Side effect was observed only in one patient with abdominal pain and diarrhea, which was subsided after interruption of administration. These results suggested that Ketotifen was effective in tratment of allergic rhinitis.
최경종,은선진,이성형,송계원 영남대학교 의과대학 1991 Yeungnam University Journal of Medicine Vol.8 No.1
In 1962, a case of "generalized skeletal dysplasia with multiple anomalies" was reported by Taybi as a new clinical syndrome. The most characteristic features of the syndrome seemed to be hearing loss, cleft palate and peculiar digital anomalies, so, the syndrome designated as otopalatodigital syndrome by Dudding, et al. Recently, The authors have experienced a case OPD syndrome who visited Yeungnam University Hospital with the chief complaint of hypernasality, and underwent pharyngoplasty for correction of VPI. We present here a new case and review the literature on the subject.
흰쥐의 간섬유화 과정에서의 교원질의 다형성 및 양적 변동
조준승,류현모,은선진,김인산 ( Joon Seung Jo,Hyun Mo Ryoo,Sun Jin Eun,In San Kim ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.4
Macromolecular collagen components in rat liver at different stage of fibrosis induced by common bile duct ligation were studied. Animals were killed on the 3rd, 7th, 14th, 21st and 29th day after bile duct ligation and liver specimens and blood samples were obtained. Hepatic collagen was fractionated into neutral salt soluble, acid soluble, pepsin soluble and insoluble fractions, and hydroxyproline content of each fraction was determined. The collagen content, especially in insoluble fraction, was increased as the duration of biliary obstruction increased. Pepsin solubilized collagens were subjected to determination of the collagen types by SDS-polyacrylamide disc gel electrophoresis. The ratio of type I to type III collagen was decreased gradually with progression of fibrosis. These results indicate that an alteration in tissue collagen polymorphism as well as variations in the collagen solubility accompany the fibrotic process, suggesting possible pathogenetic implication.
Collagen Dynamics and Polymorphism in Rat Liver During Fibrogenesis
조준승,류현모,은선진,김인산,Jo, Joon-Seung,Ryoo, Hyun-Mo,Eun, Sun-Jin,Kim, In-San Korean Society for Biochemistry and Molecular Biol 1991 한국생화학회지 Vol.24 No.4
Macromolecular collagen components in rat liver at different stage of fibrosis induced by common bile duct ligation were studied. Animals were killed on the 3rd, 7th, 14th, 21st and 29th day after bile duct ligation and liver specimens and blood samples were obtained. Hepatic collagen was fractionated into neutral salt soluble, acid soluble, pepsin soluble and insoluble fractions, and hydroxyproline content of each fraction was determined. The collagen content, especially in insoluble fraction, was increased as the duration of biliary obstruction increased. Pepsin solubilized collagens were subjected to determination of the collagen types by SDS-polyacrylamide disc gel electrophoresis. The ratio of type I to type III collagen was decreased gradually with progression of fibrosis. These results indicate that an alteration in tissue collagen polymorphism as well as variations in the collagen solubility accompany the fibrotic process, suggesting possible pathogenetic implication. 백서의 총담관을 결찰하여 간섬유화를 유발하고, 그 진행에 따른 간조직내 교원질의 양적 및 질적 변화를 조사하였다. 실험동물의 총담관을 결찰하고 각각 3,7,14,21 그리고 28일째 되는 날에 얻은 간조직과 혈액을 시료로 사용하였다. 간조직내 교원질을 neutral soluble, acid soluble, pepsin soluble 그리고 insoluble fraction으로 분획채취 하였으며, 각 분획의 hydroxyproline 함량으로 교원질을 측정하였다. 담관폐쇄 이후 간기능의 저하가 나타났고, 기간이 길어짐에 따라 간경화의 척도인 간장과 비장의 종대 및 복수의 생성을 관찰하였다. 또한 담관 폐쇄기간이 길수록 간조직의 교원질 함량은 증가하였으며, 특히 insoluble fraction의 증가가 주를 이루었다. Pepsin soluble fraction을 SDS-PAGE한 결과, type I에 대한 type III 교원질의 상대적 비율이 정상조직의 20%에서 4주군에서는 45%까지 증가하였다. 이러한 결과는 섬유화가 진행됨에 따라 교원질의 양적인 변화 뿐 아니라 용해도의 변화 혹은 결합조직을 형성하는 교원질 구성의 변화 등 질적인 변화가 발생함을 보여주고 있으며, 섬유화의 발생기작과 관계가 있을 것으로 볼 수 있다.
윤석근(Seok Keun Yoon),은선진(Sun Jin Eun),남혜주(Hae Ju Nam) 대한두경부종양학회 1990 대한두경부 종양학회지 Vol.6 No.1
It is well known that laryngeal papilloma has a tendency for malignant transformation, but the incidence was variable among many authors. The authors present a case of laryngeal cancer which was considered to be transformed from laryngeal papilloma after six years follow up, with serial pathological review of the specimen. Incidence of malignant transformation in our hospital is 2.5% of total laryngeal papilloma and it is the only case among 57 laryngeal cancer for 6 years duration. It must be stressed that long term follow up is recommanded in adult type laryngeal papilloma.