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의예과 과정에서 이중 교육목표 달성을 위한 신규 교과목 의학과 의료(의학개론) 의 개발
김용일(Yong Il Kim),윤성도(Sung Do Yun),안윤옥(Yoon Ok Ahn),고윤웅(Yun Woong Ko) 한국의학교육학회 1993 Korean journal of medical education Vol.5 No.1
As a part of study on curricular renovation in the premedical program, a new course entitled Medicine : Science and Practice was developed in an otherwise traditional premedical education setting wi th hopeful linkage of two objectives aiming for effective delivery of traditional academic contents from individual disciplines and drawing of a strong motivation toward future medical carrier development. The course was divided into two parts : a series of lectures at the phase I (the second semesters of Year I) and a subsequent session of student-centered seminars in small group session at the phase II (the first semester of Year II ). The topics in lectures and seminars were selected among the more practical, contemporary and hot medico-social issues being specifically designed to meet the educational needs/concepts of motivation for future medical carrier development , students learn from students versus self-instruction and active participation in learning process . Integration of basic sciences/cultural subjects to professional medical sciences/practice was more emphasized together with increase of attention to the humanity and socio-econonmic courses by which cultivation of problem-solving ability is possible instead of the present science-focused approach. The small group study was persistently encouraged in phase II to develop their confidence in successfulness of self learning. The course was also specifically designed to promote the habit of critical thinking on current medical issuse, to stimulate learning of general educational disciplines by usage of medical phenomena. The details of curricular development and operational strategies were described with examples.
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윤중현,김상덕,윤성도,김종빈 조선대학교 생산기술연구소 1995 生産技術硏究 Vol.17 No.1
In this paper, we designed in optimum conditions Rib-type optical waveguide which be the most basic of integrated optical device. When index of clad layer, core layer, and buffer layer in fabricated PSG film on silicon by LPCVD method are each 1.454, 1.465, and 1.447, we designed Rib-type optical waveguide by using EIM. As the result, when clad layer, core layer, and buffer layer are each 3㎛, 3㎛, 10㎛, we found that mode is single mode at 1.2 ~ 4.8㎛ of core thickness, and in case of etching by 4㎛, 0.1 ~ 4.4㎛ of core width is single mode region. At this time, as a result of simulation using BPM with changing core width at single mode region, we found that become optimum conditions at 4㎛ of core width when waveguide is etched by 4㎛ under the condition of 3㎛ clad layer, 3㎛ core layer, and 10㎛ buffer layer.
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실리카 박막을 이용한 저손실 광도파로 제작에 관한 연구
金商德,尹星燾,金鍾彬 조선대학교 동력자원연구소 1994 動力資源硏究所誌 Vol.16 No.1
In this paper, we fabricated optical waveguide to be etched PSG layer by RIE method after formation optical waveguide pattern at thin films by focusing laser beam exposed mothod using PSG propagative thin films by LPCVD, and the near field pattern was single mode in case optiacl waveguide is wide of 5㎛ and core layer of 3㎛. We could fabricated optical waveguide of very low optical loss as 2.9dB/㎝ at λ=1.3㎛ and 4.1dB/㎝ at λ=1.55㎛ when fabricated optical waveguede anneal for 10min at 1000℃, and optical loss was 2.8dB/㎝ at λ=1.3㎛ and 4.1dB/㎝ at λ=1.55㎛ when silica thin films doped 3.7% of P deposite by 3㎛ as clad after annealing for 10min at 1000℃. As mentioned above, optical loss could low along best condition of doped P and annealing when optical waveguide fabricate using PSG thin films.
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난소암에서 종양억제유전자들의 Multiple Methylator Phenotypes
류효충,조치흠,권상훈,박준철,서민애,정선욱,이정호,김종인,윤성도,차순도 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.3
지금까지 알려진 바로는 종양억제유전자와 관련해서 CpG island의 methylation 이상으로 종양억제유전자의 기능 변화가 암 형성에 관여한다고 알려져 있다. 최근의 연구 결과 대장암이나 유방암에서 이러한 hypermethylation이 진단적 지표자로서의 사용가능성을 제시하였다. 따라서 난소암 환자에서 이러한 있는 종양억제유전자들의 CpG islands의 methylation의 변화를 알아보고자 하는 연구가 시도되고 있다. 지금까지 난소암에서 methylation에 관한 연구는 많이 행해져 있지 않아 본 연구자는 난소암에서 종양억제 유전자인 BRCA1, p15, p16, p21, p73, hMLH1의 methylation유무를 알아보고자 연구를 계획하였다. 난소암 13예와 정상 난소 조직 7예를 이용하여 p15, p16, p21, p73, BRCA1, hMLH1유전자들에 대한 MSPCR을 시행하였다. p15 유전자는 난소암과 정상 난소에서 모두가 methylation을 보이지 않았고, hMLH1에서는 모두에서 같은 methylation을 보여 의의가 없었다. p21 유전자는 양군 모두에서 같은 정도의 methylation을 보였고, p73 유전자는 난소암 13예 중에서 11예에서 methylation이 관찰되었으며, 정상 난소에서는 모두에서 methylation이 있었으나, 난소암에서 보다는 methylation이 적었다. p16 유전자는 난소암에서 13예 중 10예에서 methylation이 보였으나 정상에서도 methylation이 모두 관찰되었다. BRCA1 유전자는 난소암에서 11/13 (85%)에서 methylation이 있었고, 정상에서는 4/7 (57%)에서 methylation이 나타나 차이를 확인하였다. 이상의 결과로 저자가 확인한 난소암에서의 methylation 이상은 BRCA1 유전자에서 정상과 비교하여 차이를 확인하였으며, BRCA1 유전자의 methylation 변화가 난소암의 암화 과정에 관계한다는 것을 유추할 수 있겠다. 그러나 표본 수가 적은 관계로 향후 좀더 많은 난소암과 대조군을 가지고 이러한 MSPCR 방법을 이용해 종양억제유전자의 변이나 발현 감소를 적절한 표적 CpG islands를 찾아 시행하면 좋은 결과를 보게 되리라 생각된다. Objective : Recent evidence suggests that aberrant methylation of CpG islands is a major pathway leading to the inactivation of tumor suppressor genes and development of cancer. The purpose of this study was to detect the methylation in ovarian cancer. Methods : Recent studies on colorectal and breast cancer have defined a CpG island methylator phenotype, which involves the targeting of multiple genes by promotor hypermethylation. Little is currently known about the role of methylation in ovarian cancer. To detect the methylation in ovarian cancer, we have investigated the methylation status of 13 primary ovarian cancers at six genes using methylation specific polymerase chain reaction compared with 7 normal ovaries. Results : Six of tumor suppressor genes (p15, p16, p21, p73, BRCA1, and hMLH1) were evaluated to see the methylation status. Methylation of p15, p21, p73, and hMLH1 did not detect in ovarian cancers compared with normal ovaries. Ten of 13 ovarian cancers showed methylation of p16 gene and all normal ovaries showed hypermethylation. The BRCA1 gene was methylated in 11 (85%) of 13 ovarian cancers, 4 (57%) of 7 normal ovaries. Conclusion : Methylation of the BRCA1 gene is common alteration in ovarian cancers, and may paly a part of role in pathogenesis of ovarian cancer.
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