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- 저자 : 윤석범 ( Seog Beom Yoon ) (검색결과 3 건)
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자궁경부 국소적 진행암에서 선행 화학요법으로서 Cisplatin , Ifosfamide , Paclitaxel ( CIP ) 의 phase Ⅱ 연구
윤석범(Seog Beom yOON),이종국(Jong Kug Lee),전섭(Seob Jeon),이지연(Ji Yeon Lee),최승도(Seung Do Choi),배동한(Dong Han Bae) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
목적 : 본 연구는 국소적으로 진행한 자궁경부 편평 세포암환자를 대상으로 Cisplatin,Ifosfamide, Paclitaxel(CIP)을 이용한 선행화학요법의 효과 및 독성을 연구하기 위한 목적으로 설정되었다 방법 : 1997년 2월부터 1999년 2월까지 자궁 경부 편평 세포암으로 확진된 40명(28 Ib2-IIa, 5 IIb, 4 IIIa, 2 IIIb, 1 IVa)의 환자를 대상으로 하였으며, 첫째날 paclitaxel 175mg/㎡를, 둘째날 cisplatin 50mg/㎡와 ifosfamide 5g/㎡, mesna 5mg/㎡를, 그리고 세째날 mesna 3mg/㎡을 투여하여 각 3주간 격으로 3회의 치료를 시행한 후 광범위 자궁적출술 및 임파선 절제술을 시행, 그 반응성을 조사하였다.결과 : 모든 40명의 환자의 임상적 반응율을 평가하였으며 또한 35명의 환자에서 수술을 시행하여 병리학적 반응율을 평가하여 으로 7예의 환자에서 완전 반응을 보였고 8예에서 적절한 부분 반응을 보였으며, 15예에서 미흡한 부분반응을, 5예에서 무반응양상을 보였고 평균 19개월간(15-31개월) 추적 조사한 결과 35예는 재발 없이 생존하였고, 4예에서 재발하였으며 나머지 1예는 사망하였다. 또한 독성에 관한 결과가 조사되었으나 그로 인한 심각한 합병증은 발생하지 않았다. 결론 : 국소적으로 진행된 자궁경부 편평 세포암에 있어서의 CIP regimen을 사용한 본 연구에서 병리학적 완전 반응 및 적정 부분 반응을 보인 경우는 37.5%로 나타났으며, 비교적 수용 가능한 범위 내에서의 독성 반응을 나타냈다. 앞으로는 본 약물을 이용한 선행화학 요법으로 질병의 진행여부 및 생존율 등 반응에 관한 좀 더 많은 예의 평가연구가 시행되어져야 할 것으로 생각된다. Objective : To evaluate the efficacy and toxicity of Cisplatin, Ifosfamide, Paclitaxel as neoadjuvant chemotherapy in 40 patients with locally advanced cervical squamous cell carcinoma.Methods : Forty patients with pathologic confirmed cervical squamous cell caner (28 Ib2-IIa, 5 IIb, 4 IIIa, 2 IIIb, 1 IVa) were prospectively enrolled in the study from Feb 1997 to Feb 1999. Patients with locally advanced squamous cell carcinoma were submitted to three courses of neoadjuvant chemotherapy (CIP) followed by surgery. Their treatment consisted of paclitaxel 175 mg/m2 given over three hours on day 1, cisplatin 50 mg/m2, ifosfamide 5 g/m2 in a 24-hour continuous infusion and mesna 5 g/m2 in a 24-hour continuous infusion on day 2 and mesna 3 g/m2 in a 24-hours continuous infusion on day 3. The course was repeated every three weeks for three courses and all of the patients excepted those with disease progression or who were inoperable, were scheduled for radical hysterectomy and pelvic lymphadenectomy.Results : All 40 patients were evaluated for response and toxicities. 35 patients underwent surgery, seven(17.5%) had pathology documented complete response, eight(20.0%) had partial responses with only microscopic residual disease in the cervix, fifteen(37.5%) had suboptimal partial responses and five(12.5%) had stable disease. And five(12.5%) patients had not performed surgery. The toxicities were studied and the results were evaluated with relatively acceptable range. At a median follow up period of 19 months(range 15-31 months), 35(87.5%) women are alive without recurrence, four are alive with recurrent disease and one died due to the disease. Conclusion : CIP regimen on the locally advanced cervical squamous cell carcinoma, yielded a 37.5% complete and optimal partial response rate with acceptable toxicity. And it should be done that adequate following up prospectively for determine the impact of CIP regimen in time to progression and survival.
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2차원 및 3차원 초음파를 이용한 태아표면의 해부학적 선별 검사에 관한 연구
윤석범,이해혁,이정재,최경훈,이순곤,이임순,이권해 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2
Objective : Our purpose of this study was to determine the clarity and consuming time of fetal surface screening in thirty-eight fetuses from 24 to 32 weeks of gestation by use of two and three-dimensional ultrasonography. Methods : From May 1998 to July 1998, we performed the fetal surface screening of the fetal face, extremities, and spine. Thirty-eight fetuses of 24-32 weeks of gestation (thirty-seven normal fetuses and one abnormal fetus) were studied by use two-dimensional (AI 5200S, 3.5-5.0MHz; Acoustic Imaging Technologic Cooperation, U.S.A.) and three-dimensional ultrasonography (Volusion 530D, 3.5-5.0 MHz ; Kretz-Medicine, Korea). On the fetal face, we evaluated both orbits, nose, lips and brow. Both hands and feet, five digits and toes should be seen in this study. We evaluated cervical spine and lumbosacral junction of the spine. Results : The maternal average age of 38 patients was 29.9 years and the average gestational age was 29.7 weeks. The results of fetal surface screening were as follows : face (both orbits 89.5%, lips 92.1%, nose 92.1%, and brow 89.5%), extremities (both hands 68.4% and feet 73.7%), and spine (cervical spine 94.7% and lumbosacral junction 97.4%) by use of two-dimensional ultrasonography. By use of three-dimensional ultrasonography, results were as follows : face (both orbits 76.3%, lips 81.6%, nose 81.6%, and brow 78.9%), extremities (both hands 76.3% and feet 78.9%), and spine (cervical spine 71.1% and lumbosacral junction 73.7%). Consuming time for two-dimensional ultrasonography were 4.7 minutes for face, 11.6 minutes for extremities, and 5.7 minutes for spine. Using three-dimensional ultrasonography results were 12.8 minutes for face, 17.9 minutes for extremities, and 11.7 minutes for spine. Average consuming time of all fetal anatomic screening was 22.0 and 42.4 minutes by use of two and three dimensional ultrasonography. In one abnormal fetus had cleft lip and polydactyly of right foot which were detected all by three-dimensional ultrasonography, but we couldn't detect the polydactyly by two-dimensional ultrasonography. Conclusion : Three-dimensional ultrasonography was more time-consuming method, but we suggested that three-dimensional ultrasonography was superior than two-dimensional ultrasonography in fetal surface screening.
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