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RISS 인기검색어
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- 저자 : 윤경환(Kyung Whan Yoon) (검색결과 3 건)
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원발성 간암에 있어서 종양표지자로서 이상 Prothrrombin ( PIVKA - 2 ) 측정의 유용성
이숭(Soong Lee),윤경환(Kyung Whan Yoon),구철(Chul Koo),최성규(Sung Kyu Choi),유종선(Jong Sun Rew),윤종만(Jong Mann Yoon) 대한내과학회 1990 대한내과학회지 Vol.39 No.1
N/A Abnormal prothrombin, known as PIVKA-II (protein induced by vitamin K absence or antagonist-II) or DCP (des-γ-carboxyprothrombin), is released from the liver into the blood of patients with vitamin K deficiency or vitamin K antagonist users (wafarin sodium), or patients with various liver diseases, especially hepatocellular carcinoma. Recently. abnormal prothrombin has been reported to be as good a marker of hepatocellular carcinoma as alpha-fetoprotein (AFP), and its production may be due to the reduction of vitamin K-dependent carboxylase activity. In order to assess the usefulness of abnormal prothrombin and the correlation between abnormal prothrombin and AFP in hepatocellular carcinoma, we measured the plasma abnormal prothrombin using enzyme immunoassay in 60 patients with liver diseases and in 15 healthy controls. The results were as follows: 1) The mean value of plasma abnormal prothrombin in the normal controls was 0,06±0.02 AU/ml. 2) The mean value of plasma abnormal prothrombin in patients with hepatocellular carcinoma was 5.82±4.78 AU/ml, and there were significant differences between hepatocellular carcinoma and liver cirrhosis, chronic hepatitis and other non-tumorous liver diseases. The positivity of abnormal prothrombin in hepatocellular carcinoma was 70.6% 3) The sensitivity and specificity of plasma abnormal prothrombin as a marker of hepatocellular carcinoma with a diagnostic cut-off value of 0.13 AU/ml were 70.6% and 90.7%, and they were 58.8%, and 97.7% with a cut-off value of 3.0 AU/ml, respectively. The sensitivity and specificity of AFP with a diagnostic cut-off value of 20 ng/ml werC 64.7% and 76.6% and they were 35.3% and 95.3% with a cut-off value of 400 ng/ml, respectively 4) 1 here was no significant correlation between the plasma abnormal prothrombin and serum AFP in patients with hepatocellular carcinoma (r=0.45 p>0. 05). 5) There was no significant correlation between the tumor size and plasma abnormal prothrombin (r=0.04, p>0.05) or the serum AFV level (r=0.01, p>0.05). These results suggest that plasma abnormal prothrombin could be employed as a useful tumor marker together with AFP in patients with hepatocellular carcinoma.
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암성 복수의 감별진단에 있어 복수내 Fibronectin , Sialic Acid , 혈청 - 복수간 알부민 농도차 측정의 임상적 의의
이숭(Soong Lee),윤경환(Kyung Whan Yoon),최성규(Sung Kyu Choi),유종선(Jong Sun Rew),윤종만(Jong Mann Yoon),김미정(Mi Jung Kim) 대한내과학회 1990 대한내과학회지 Vol.39 No.1
N/A The differential diagnosis of ascites remains a problem in clinical practice, Although ascites is most often caused by chronic liver disease, by neoplasms metastatic to the peritoneum, and by tuberculous peritonitis, a complete differentiation has not been possible using simple and reliable parameters in ascitic fluid. Cytologic examination, despite its high specificity, also has limitations in differentiating ascites because of its low sensitivity. We measured the ascitic fluid concentration of fibronectin, sialic acid and the serum-ascites albumin difference in order to assess the diagnostic significance of these parameters for defferentiating ascites of various causes in 49 patients, 33 with liver cirrhosis and 16 with peritoneal metastasis. The results were as follows: 1) The mean concentrations of ascitic fibronectin (122.50±96.09ug/ml) and sialic acid (52.00±22.23 mg/dl) in malignant ascites were significantly higher the those of the liver cirrhosis group (p<0,001). The mean serum-ascites albumin difference (1.14±0.59 g/dl) in the malignant ascites group was significantly different from that of the liver cirrhosis group (2.67±0.54 g/dl), (p<0.001). 2) The highest diagnostic accuracy in malignancy was the value of serum-ascites albumin difference (97.8%) rather than ascitic sialic acid and fibronectin (83.7%, 80.0% respectively). 3) The highest specificity in differentiating liver cirrhosis with hepatocelluar carcinoma from peritoneal metastasis was ascitic fibranectin. These results suggested that the measurement of ascitic fibronectin, sialic acid, and serum-ascites albumin difference, combined with conventional parameters such as ascitic lactic dehydrogenase and total protein, may be useful for differentiating various causes of ascites.
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김영진,윤경환,정용환,김세종,유종선,윤종만,신동현,안영주,성종호 대한소화기내시경학회 1992 Clinical Endoscopy Vol.12 No.2
The incidence of synchronous gastric cancer is variously reported to be 2.07%, 5.22%, 6.5%, 8.6%, or 9% and has been increasing recently, probably with advance in the diagnosis of gastric cancer. Our case in presentation is a 70-year-old male patient who had total gastrectomy and esopbagiojunostomy done for synchronous four gastric cancer. Each has different histologic types, Some of these lesions are not suspected before operation and are found almost by chance during histologic examinations after surgery performed only to remove main lesion. So we report this case with a review of literatures.
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