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- 저자 : 유한석 ( Han Seok Yoo ) (검색결과 3 건)
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E-ICP와 ICP를 이용한 MIS(Mo/HfO₂/Si) Capacitor의 Plasma Etching Damage 연구
유한석(Han-seok Yoo),양승국(Seung-kook Yang),김한형(Han-hyung Kim),이승용(Seung-yong Lee),신상현(Sang-Hyun Sin),박세근(Se-Geun Park) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7
Characteristics of HfO₂ and Mo are compared using ICP and E-ICP. E-ICP that used axis magnetic field to ICP to improve plasma density is improved etch selectivity of Mo and HfO₂ than ICP. We analyzed plasma etching damage causing in etch process to manufacture MIS(Mo/HfO₂/Si) Capacitor - comb pattern with the same area but different periphery length. As a result, leakage current of E-ICP was larger than ICP. Through these result, E-ICP was improved selectivity of Mo and HfO₂ because axis magnetic field increased plasma density, but E-ICP had characteristics decreasing of uniformity, electron shading effect and selective increase of ion charge.
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연산 오골계 물 추출물이 조골세포와 파골세포의 활성에 미치는 영향
유한석 ( Han Seok Yoo ),정강현 ( Kang Hyun Chung ),이권재 ( Kwon Jai Lee ),김동희 ( Dong Hee Kim ),안정희 ( Jeung Hee An ) 한국미생물생명공학회(구 한국산업미생물학회) 2015 한국미생물·생명공학회지 Vol.43 No.4
본 연구는 연산 오골계의 물 추출물을 이용하여 MG-63 조골세포와 RAW 264.7 파골세포의 분화에 미치는 영향을 분석하였다. 조골세포의 분화에 미치는 영향을 관찰하기 위해 ALP 활성 분석과 alizarin red 염색을 통해 골 석회화를 측정하였다. 그리고 RAW 264.7 파골세포의 분화 억제 활성을 확인하기 위해 TRAP 활성과 염색을 분석 측정하였다. 연산오골계 물 추출물을 농도별(250-1,000 μg/ml)로 처리한 결과 조골세포와 파골세포에서 세포독성을 나타내지 않았다. ALP 활성은 3년산 암탉 육질이 133.8%, 3년산 수탉 육질은 129.6%로 육질이 껍질보다 조골세포 분화력이 높았다. 그리고 육질에서는 3년산이 1년산보다 ALP 활성이 높으나 껍질에서는 1년산이 3년산보다 조골세포 분화능력이 높았다. 성별 간 ALP 활성은 전체적으로 암탉이 수탉보다 높은 ALP 활성을 보였다. 또한, 골 석회화 능력은 3년산 암탉 육질이 연령과 성별을 통틀어 124.3%로 가장 뛰어났으며 TRAP 활성은 3년산 수탉 육질이 31.8%로 연령과 성별을 통틀어 억제 활성이 가장 뛰어났다. 연산 오골계 물 추출물은 조골세포 분화능력이 뛰어나 골의 석회화를 촉진하는 능력이 뛰어났으며 파골세포의 분화를 억제하여 골 흡수를 억제하는 능력이 뛰어났다. 이에 연산 오골계는 골 기능 강화와 골 관련질환에 대한 예방과 치료에 효과가 있을 것으로 보인다. The effects of water extracts of Gallus gallus var. domesticus (Yeonsan ogolgye, GD) on the activities of osteoblast differentiation and the restraint of osteoclast formation were investigated. The water extract of GD in the human osteoblast “MG-63” cell, was examined in relation to alkaline phosphatase (ALP) activity and alizarin red stains. In order to observe the effects of osteoclasts formation, we analyzed RAW 264.7 cell tartrate-resistant acid phosphatase (TRAP) activity and TRAP stains. The ALP activity of the water extract of hen and cock flesh (3 years) were 133.8% and 129.6%, respectively. The ALP activity of flesh extracts was also higher than that of the skin extracts. Concerning the effects of age, the 3 years old flesh extracts had a higher activity than that of the one year old extracts. However the activity of the 3 years old skin extracts was lower than that of the one year old extracts. For gender conditions, the ALP activity of the hen extract was higher than that of the cock. The degree bone mineralization in the three years old hen flesh exhibited the highest rate, at 124.3%, amongst all the groups. The TRAP activity of the flesh extracts of the three years old cock revealed the lowest rate, at 31.8%, compared to the control. Our results demonstrate that the water extract of GD increases bone mineralization and osteoblast differentiation activity in MG-63 cells and enhances the inhibitory activity of bone-resorption in RAW 264.7 cells. In conclusion, the water extracts of GD seem to be effective in the prevention and treatment of bone related disorders.
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강석영(Seok Young Kang),신명철(Myung Chul Shin),유한석(Han Seok Yoo),이용섭(Yong Seop Lee),박철원(Chul Won Park),태 경(Kyung Tae) 대한두경부종양학회 2008 대한두경부 종양학회지 Vol.24 No.2
Background and Objectives :Peripheral nerve sheath tumors(PNSTs) are uncommon neoplasm in the head and neck region. The treatment of PNSTs is surgical removal, but excision cause neurologic complications. This study was performed to evaluate the proper diagnosis and treatment of PNSTs with our experiences. Subjects and Method :During the period from October 1994 to July 2007, 58 patients were diagonised with PNSTs in head and neck region. We reviewed medical records and imaging study retrospectively. Result :95%(55/58) of the PNSTs in head and neck were benign;5%(3/58) were malignant peripheral nerve sheath tumors(MPNSTs). 63%(37/58) were neurilemoma, 20%(17/20) were neurofibroma, 2%(1/58) was perineuroma. 55 patients underwent surgery. 80%(45/55) of cases were treated with excision. Enucle-ation was performed in 7(14%) patients. All cases of benign neurogenic tumors showed no recurrence. Among 3 of MPNSTs 2 patients were Von Recklinghausen’s disease and expired with regional recurrence and lung metastasis. Conclusion :The benign PNSTs can be treated with enucleation if possible and observation can be another choice to minimize neurologic sequele.
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