Study on relationship between "cholestrol·cardiorenal connective tissue weakness type" and TNF-alpha gene polymorphism in iris constitution analysis

유춘상,황우준,김경식,최성용,김종욱,Yoo, Chun-sang,Hwang, Woo-jun,Kim, Kyung-sik,Choi, Sung-yong,Kim, Jong-uk The Korean AcupunctureMoxibustion Medicine Society 2004 대한침구의학회지 Vol.21 No.2

홍채학은 대체의학의 한 분야로서 홍채 침착의 불규칙성을 주시함으로써 의학적 상태를 진단한다. 홍채학적 분류에 의한 체질은 가족력을 보이고 있으며 이는 홍채체질의 유전성을 의미한다. 강력한 면역조절자이며 전 염증성 사이토카인인 종양괴사인자(tumor necrosis factor-a, TNF-${\alpha}$)는 많은 병리적 과정에서 중요한 역할을 한다. 따라서 본 연구자는 고혈압환자에서 홍채체질과 TNF-${\alpha}$ 유전자 다형성과의 관련성을 조사하였다. 87명의 고혈압 환자와 79명의 정상인을 홍채체질에 따라 분류하였으며 이들의 TNF-${\alpha}$ 유전자형을 분석하였다. 결과적으로 정상인에 비하여 TNF-${\alpha}$ GA 이형접합체의 빈도가 고혈압 환자군에서 감소하였다. 이 같은 결과는 TNF-${\alpha}$ 다형성이 고혈압에 대한 저항성과 관련 있음을 의미한다. 또한 고혈압환자에서 콜레스테롤 침착체질과 심신 결합조직 허약 체질은 42.5%로서 정상인 16.5%에 비하여 현저하게 증가하였다 (P<0.001). GG TNF-${\alpha}$ 유전자형을 갖고 있는 군에서 심신 결합조직 허약체질과 콜레스테롤 침착체질의 빈도는 정상인보다 환자에서 유의하게 높았다(P<0.001). 본 연구에서 저자는 홍채체질과 고혈압사이의 관련성을 발견함과 동시에 TNF-${\alpha}$ 유전자 다형성과 고혈압, 그리고 홍채 체질과의 관련성을 최초로 입증하였다.

스트레인을 받는 수소 / 공기 / 수증기 예혼합화염의 소염에 관한 수치해석적 연구 ( A Numerical Analysis on the Extinction of Strained Hydrogen / Air / Steam Premixed Flames )

유춘상,이승동,정석호 대한기계학회 1997 대한기계학회 춘추학술대회 Vol.- No.-

Study on relationship between "cholestrol· cardio-renal connective tissue weakness type" and TNF-alpha gene polymorphism in Iris constitution analysis

유춘상,황우준,김경식,최성용,김종욱 대한침구의학회 2004 대한침구의학회지 Vol.20 No.6

Iridology, one of complementary and alternative medicine (CAM), is the diagnosis of the medical conditions through noting irregularities of the pigmentation in the iris. Iridological constitution has a strong familial aggregation and is implicated in heredity. Tumor necrosis factor-a (TNF-a), a potent immune modulator and pro-inflammatory cytokine, has been implicated in many pathological processes. Then I investigated the relationship between iridological constitution and TNF-a gene polymorphism in hypersensitive patients. I classified 87 hypertensives and 79 controls according to Iris constitution, and determined TNF-a genotype. As a result, compared to controls, the frequency of the TNF-a GA heterozygote was decreased in hypertensives, although the statistical significancy was marginal (P=0.08). This result implies an association with resistance to the disease. Also, cardio-renal connective tissue weakness type+cholesterol in hypertensives was 42.5% compared with 16.5% in controls (P<0.001). The frequency of cardio-renal connective tissue weakness type + cholesterol was significantly higher in hypertensives with GG genotype than in the remaining Iris constitutions (P<0.001). In this study, the author found the relationship between the Iris constitution and hypertension, and an association among TNF-a gene polymorphism, hypertension, and Iris constitution. 홍채학은 대체의학의 한 분야로서 홍채 침착의 불규칙성을 주시함으로써 의학적 상태를 진단한다. 홍채학적 분류에 의한 체질은 가족력을 보이고 있으며 이는 홍채체질의 유전성을 의미한다. 강력한 면역 조절자이며 전 염증성 사이토카인인 종양괴사인자 (tumor necrosis factor-a, TNF-α)는 많은 병리적 과정에서 중요한 역할을 한다. 따라서 본 연구자는 고혈압환자에서 홍채체질과 TNF-a 유전자 다형성과의 관련성을 조사하였다. 87명의 고혈압 환자와 79명의 정상인을 홍채체질에 따라 분류하였으며 이들의 TNF-α 유전자형을 분석하였다. 결과적으로 정상인에 비하여 TNF-α GA 이형접합체의 빈도가 고혈압 환자군에서 감소하였다. 이 같은 결과는 TNF-α 다형성이 고혈압에 대한 저항성과 관련 있음을 의미한다. 또한 고혈압환자에서 콜레스테롤 침착체질과 심신 결합조직 허약 체질은 42.5%로서 정상인 16.5%에 비하여 현저하게 증가하였다 (P<0.001). GG TNF-α 유전자형을 갖고 있는 군에서 심신 결합조직 허약 체질과 콜레스테롤 침착체질의 빈도는 정상인보다 환자에서 유의하게 높았다 (P<0.001). 본 연구에서 저자는 홍채체질과 고혈압사이의 관련성을 발견함과 동시에 TNF-α 유전자 다형성과 고혈압, 그리고 홍채체질과의 관련성을 최초로 입증하였다.

한번 더 읽어주시지요 - 까치집

유춘상 샘터사 1995 월간 샘터 Vol.26 No.3

DNSs of ignition of a temporally evolving water jet under oxy-fuel HCCI combustion conditions

Gwang Hyeon Yu(유춘상),Jong Hak Kim(김종학),Suk Ho Chung(정석호),Chun Sang Yoo(유춘상) 한국연소학회 2021 KOSCOSYMPOSIUM논문집 Vol.2021 No.5

A DNS study of ignition characteristics of a lean iso-octane/air mixture under HCCI and SACI conditions

유춘상(Chun Sang Yoo) 한국연소학회 2011 KOSCOSYMPOSIUM논문집 Vol.- No.43

The effect of thermal stratification, spark-ignition, and turbulence on the ignition of a lean homogeneous iso-octane/air mixture at constant volume and high pressure is investigated by direct numerical simulations (DNS) with a new 99-species reduced kinetic mechanism developed for very lean mixtures from the detailed mechanism (Mehl et al., 4th European Combustion Meeting, Vienna, Austria, 2009). Two-dimensional DNS are performed in a fixed volume with two-dimensional isotropic velocity spectrums, temperature fluctuations, and ignition source superimposed on the initial scalar fields. The influence of variations in the initial temperature field imposed by changing the variance of temperature, the ignition-timing by changing the time at which ignition source is superimposed, and the turbulence intensity and length scale on ignition of a lean iso-octane/air mixture is elucidated. The mean heat release rate increases more slowly and ignition delay decreases with increasing thermal stratification under homogeneous charge compression-ignition (HCCI) condition since the present mean temperature lies far outside of the negative temperature coefficient (NTC) regime. The spark-ignition induces relatively short ignition delay under spark-assisted compression ignition (SACI) condition while slightly spreading out the mean heat release rate. For SACI combustion, high turbulence intensity decreases the ignition delay more by increasing turbulent flame area. Displacement speed and Damkohler number analyses reveal that the high degree of thermal stratification induces deflagration at the reaction fronts, and hence, the mean heat release rate is smoother subsequent to thermal runaway occurring at the highest temperature regions in the domain. For SACI combustion, the heat release occurs solely by deflagration prior to the occurrence of the maximum heat release and subsequently by the mixed mode of deflagration and spontaneous ignition. These results suggest that the thermal stratification is more effective for smooth operation of HCCI engines and the spark-ignition can precisely control the ignition timing for SACI combustion.

DNS of ignition of a lean n-heptane/air mixture under HCCI conditions

유춘상(Chun Sang Yoo),Jackquiline H. Chen 한국연소학회 2010 KOSCOSYMPOSIUM논문집 Vol.- No.41

The effect of thermal stratification on the ignition of a lean homogeneous n-heptane/air mixture at constant volume and high pressure is investigated by direct numerical simulations (DNS) with a new 58-species reduced kinetic mechanism. 2-D DNS are performed in a fixed volume with a two-dimensional isotropic velocity spectrum and temperature fluctuations superimposed on the initial scalar fields. The influence of variations in the initial temperature field, imposed by changing the mean and variance of temperature on multi-stage ignition of a lean n-heptane/air mixture is studied. In general, the mean heat release rate increases more slowly with increasing thermal stratification regardless of the mean initial temperature. Ignition delay decreases with increasing thermal stratification for high mean initial temperature relative to the negative temperature coefficient (NTC) regime. It is, however, retarded with increasing thermal fluctuations for relatively low mean initial temperature resulting from a longer overall ignition delay of the mixture. Displacement speed and Damkohler number analyses reveal that the high degree of thermal stratification induces deflagration rather than spontaneous ignition at the reaction fronts, and hence, the mean heat release rate is smoother subsequent to thermal runaway occurring at the highest temperature regions in the domain. These results suggest that the critical degree of thermal stratification for smooth operation of homogeneous charge compression-ignition (HCCI) engines depends on both the mean and fluctuations in initial temperature which should be considered in controlling ignition timing and preventing an overly rapid increase in pressure in HCCI combustion.

CO-O2 예혼합화염의 후류상호작용에 관한 H2O 첨가 효과

김경택,권오붕,유춘상,박정,정석호 한국연소학회 2022 한국연소학회지 Vol.27 No.1

Numerical study is conducted to understand the effects of additional H2O on downstream interaction in CO-O2 counterflow premixed flames. Adding 1% H2O to fuel side for freely-propagating premixed flame with CO-O2 mixture increases laminar burning velocity from 5.3 cm/s to 81.8 cm/s in a way that the main oxidation reaction is changed from CO + 0.5O2 → CO2 to CO + OH → CO2 + H. When global strain rate reaches 23.5 s-1 for interacting CO-O2 premixed flames, the flames cannot be sustained. While for (0.1% H2O + CO)-O2 premixed flames, the flame is extinguished at 2687 s-1. Because the fuel Lewis number and effective one are larger than unity, downstream interaction are mainly through chemical one. For lean-lean (rich-rich) flames, the production of O (H) radical is vigorous, resulting in the formation of OH via H2O + O → OH + OH (H2O + H → OH + H2). These different chemical situations can influence downstream interactions in various flame configurations. Such interesting aspects in chemical interactions are presented and discussed in detail

박막의 증발 중 나타나는 이원 혼합물의 자가 분리에 미치는 유체 흐름의 영향

정나리나,서해원,유춘상 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.5

Oscillatory dynamics of colloidal particles by surfactant in an evaporating droplet

서해원,정나리나,유춘상 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.5