http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Soon Oh Kwon(권순오),Kyeong-Hyeon Byeon(변경현),Jae-Wook Chung(정재욱),Yun-Sok Ha(하윤석),Seock Hwan Choi(최석환),Bum Soo Kim(김범수),Hyun Tae Kim(김현태),Tae-Hwan Kim(김태환),Eun Sang Yoo(유은상),Ghil Suk Yoon(윤길숙),Jun Nyung L 대한비뇨기종양학회 2020 대한비뇨기종양학회지 Vol.18 No.2
Purpose: To determine an appropriate surgical technique, it is important to predict pathological results for patients with clinically localized prostate cancer (PCa) eligible for nerve-sparing radical prostatectomy (NSRP). Several studies have highlighted that serum testosterone level was associated with aggressive features of PCa. Therefore, we analyzed factors, including serum testosterone, to predict upstaging and upgrading after surgery for patients with clinically localized PCa eligible for NSRP. Materials and Methods: We retrospectively evaluated patients who underwent radical prostatectomy (RP) between January 2015 and May 2018 at our institution. Patients with Gleason grade group 1 or 2 on biopsy, prostate-specific antigen<10, and ≤clinical/radiologic stage T2 were included in this study. Upstaging and upgrading were defined as pathological stage≥T3a and Gleason grade group≥3, respectively. We evaluated the patients’ demographics and outcomes according to upstaging and upgrading after surgery. Predictive factors for upstaging and upgrading were analyzed using a multivariate logistic regression model. Results: Of 108 patients included in the study, upstaging and upgrading after surgery were observed in 24 (22.2%) and 36 (33.3%), respectively. Low serum testosterone level, small prostate size, and positive core number≥3 on biopsy were identified as predictive factors for upstaging in multivariate analysis. Although serum testosterone was associated with upgrading in univariate analysis, only clinical/radiologic stage and biopsy Gleason grade group were observed as predictive factors for upgrading in multivariate analysis. Conclusions: Serum testosterone level was identified as a predictive factor for upstaging after RP for clinically localized PCa eligible for NSRP.