http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The Effects of Eupatilin (StillenⓇ) on Motility of Human Lower Gastrointestinal Tracts
유승범,오형권,유성아,문상휘,조은경,오태영,박규주 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.5
Gastrointestinal motility consists of phasic slow-wave contractions and the migrating motor complex(MMC). Eupatilin (StillenⓇ) has been widely used to treat gastritis and peptic ulcers, and variouscytokines and neuropeptides are thought to be involved, which can affect gastrointestinal motility. Weperformed a study to identify the effects of eupatilin on lower gastrointestinal motility withelectromechanical recordings of smooth muscles in the human ileum and colon. Ileum and colonsamples were obtained from patients undergoing bowel resection. The tissues were immediately storedin oxygenated Krebs-Ringer's bicarbonate solution, and conventional microelectrode recordings frommuscle cells and tension recordings from muscle strips and ileal or colonic segments were performed. Eupatilin was perfused into the tissue chamber, and changes in membrane potentials and contractionswere measured. Hyperpolarization of resting membrane potential (RMP) was observed after administrationof eupatilin. The amplitude, AUC, and frequency of tension recordings from circular andlongitudinal smooth muscle strips and bowel segments of the ileum and colon were significantlydecreased after admission of eupatilin. Eupatilin elicited dose-dependent decreases during segmentaltension recordings. In conclusion, eupatilin (StillenⓇ) showed inhibitory effects on the human ileumand colon. We propose that this drug may be useful for treating diseases that increase bowel motility,but further studies are necessary.
SEBS가 첨가된 Polypropylene의 냉각속도에 따른 기계적 특성 및 전기적 특성 연구
유승범,정재철,최석환 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
내열성이 상대적으로 우수하여 초고압 전력케이블 절연 재료의 새로운 대안으로 주목받고 있는 polypropylene에 styrene-ethylene-butylene-styrene (SEBS)을 첨가하여 초고압 전력케이블의 절연재료로서 적합하도록 기계적 물성 등을 향상시켰다. Polypropylene은 냉각속도에 따라 결정화도가 달라지며 그에 따라 기계적 강도 및 전기적 특성이 영향을 받는데, polypropylene에 SEBS를 첨가한 compound가 결정화도에 따라 기계적/전기적 특성에 영향을 미치는지 여부를 알기 위하여 200 °C hot press를 통해 sheet 샘플을 제작하였고 냉각 속도를 각각 28.0 °C/min과 1.6 °C/min로 하여 결정화도를 달리 하였다. 결정화도, 용융온도, 인장강도, 연신율, AC break down strength를 평가하여 냉각 속도가 기계적 물성과 전기적 특성에 미치는 영향을 비교하였다.
유승범,오흥권,Heon-Kyun Ha,Eun Kyung Choe,문상희,박규주 대한대장항문학회 2012 Annals of Coloproctolgy Vol.28 No.1
An anorectal foreign body can cause serious complications such as incontinence, rectal perforation, peritonitis, or pelvic abscess, so it should be managed immediately. We experienced two cases of operative treatment for a self-inserted anorectal foreign body. In one, the foreign body could not be removed as it was completely impacted in the anal canal. We failed to remove it through the anus. A laparotomy and removal of the foreign body was performed by using an incision on the rectum. Primary colsure and a sigmoid loop colostomy were done. A colostomy take-down was done after three months. The other was a rectal perforation from anal masturbation with a plastic device. We performed primary repair of the perforated rectosigmoid colon, and we didea sigmoid loop colostom. A colostomy take-down was done three months later. Immediate and proper treatment for a self-inserted anorectal foreign body is important to prevent severe complications,and we report successful surgical treatments for problems caused by anorectal foreign bodies.
유승범,오흥권,문상희,최은경,유성아,박성혜,박규주 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.6
Little human tissue data are available for slow waves and migrating motor complexes, which are the main components of small bowel motility. We investigated the electrophysiological and mechanical characteristics of human ileal motility, in vitro. Ileum was obtained from patients undergoing bowel resection. Electrophysiological microelectrode recordings for membrane potential changes and mechanical tension recordings for contraction from smooth muscle strips and ileal segments were performed. Drugs affecting the enteric nervous system were applied to measure the changes in activity. Slow waves were detected with a frequency of 9∼10/min. There were no cross-sectional differences in resting membrane potential (RMP), amplitude or frequency between outer and inner circular muscle (CM), suggesting that electrical activities could be effectively transmitted from outer to inner CM. The presence of the interstitial cell of Cajal (ICC) at the linia septa was verified by immunohistochemistry. Contractions of strips and segments occurred at a frequency of 3∼ 4/min and 1∼ 2/min, respectively. The frequency, amplitude and area under the curve were similar between CM and LM. In segments, contractions of CM were associated with LM, but propagation varied with antegrade and retrograde directions. Atropine, NW-oxide-L-arginine, and sodium nitroprusside exhibited different effects on RMP and contractions. There were no cross-sectional differences with regard to the characteristics of slow waves in CM. The frequency of contractions in smooth muscle strips and ileal segments was lower than slow waves. The directions of propagation were diverse, indicating both mixing and transport functions of the ileum.