실험용 토끼에서 Adriamycin의 혈관외 유출에 의한 시간별 육안과 조직학적 변화 및 병변내 스테로이드 투여시 치료 효과에 관한 연구

유민석 ( Min Seok Yoo ),안성구 ( Sung Ku Ahn ),최응호 ( Eung Ho Cho ),이승헌 ( Seung Hun Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5

Background: Extravasation of chemotherapeutic agents during intravenous infusion may cause extensive inflammatory reaction, ulceration, crust formation, and skin necrosis. But the exact mechanism of cutaneous reactions after extravasation of adriamycin remains unknown. Objective : Our purpose was to evaluate the clinical and histological features in rabbits after injection of adriamycin and a mixed solution of adriamycin and triamcinolone. Methods : Three rabbits were divided into three groups and were subcutaneously injected with the following materials on the back:adriamycin, a mixed solution of adriamycin and triamcinolone and 0.9% saline respectively. The injection sites including the skin and subcustaneouskfat were excised and fixed with natural huffered formalin. The biopsied specimens were stained with hematoxylin and eosin. Results : l. In the adriamycin injected group, there were induration, crust formation and ulceration after three weeks. After seven weeks crust and focal ulceration were found. Histologically, after one day mild epidermal necrosis, dermal inflammatory infiltration, destruction of epidermal appendag es, edema and hemorrhage were seen. After one week collagen necrosis was advanced and granulation tissue formation and calcium deposition were found. After seven weeks granulation tissue formation and calcium d position still remained. 2. In the adriamycin and triamcinolone injected group, focal healing ulceration was seen after three weeks. After seven weeks the ulceration healed and normal gross finding was seen. Histologically, destructior of epidermal appendages and edema were found after one day. After three weeks granulation tissue formation and fatty changes in the dermis were seen. After five weeks normal histologic findings were seen in the epidermis. Collagen necrosis became less prominent and hyalinizationand transepidermal elimination were found. After seven weeks nearly normal histological findings in the epidermis and dermis were seen. Conclusion : We conclude that there was a marked difference in the gross and histological findings between two groups of adriamycin injected and a mixed solution of adriamycin and triamcinolone injected rabbits. Therefore, we suggest triamcinolone can be used as an adjuvant mode in the treatment of lesions where adriamycin is extravasated. (Kor J Dermatol 1996;34(5): 732-738)

만성 통증 환자에성 벌침 치료후 발생한 접촉 담마진

유민석(Min Seok Yoo),안성구(Sung Ku Ahn),이승헌(Seung Hun Lee),이원수(Won Soo Lee) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5

Contact Urticaria is a wheal-and-flare response to chemicals applied to the skin. Contact urticaria due to bee sting therapy has never been reported in Korea. A 45-year-old male was seen for erythematous plsques and patches with the duration of 3 days. Histologicall, the skin biopsy specimen showed necrosis and dyskeratotic cells in the epidermis. Collagen degenerati in and perivascular lymphocytic infiltrates were seen in the upper dermis. (Kor J Dermatol 1994;32(5):895-898)

새로운 별 표시 호텔등급심사제도에서 호텔의 등급획득 성공요인에 관한 연구

유민석(Yoo, Min-Seok) 대한관광경영학회 2017 觀光硏究 Vol.32 No.6

호텔등급은 고객이 호텔을 선택하는 기준 중의 하나이며, 특히 독자적으로 운영되는 호텔들에게는 호텔의 시설, 서비스품질을 알릴 수 있는 중요한 정보이다. 호텔등급에 대한 중요성 인식이 확대되면서 정부는 그동안 공정성에 대한 문제점이 제기되었던 무궁화 표시 등급제를 대신하여 2015년도부터 새로운 별 표시 호텔등급제도를 시행하였다. 새로운 별 표시 호텔등급제도는 등급심사의 정기적인 의무화, 공공기관인 한국관광공사로의 심사주체 변경, 암행(불시)평가 도입, 등급별로 차등화된 심사기준 적용 등 제도 상으로 많은 변화가 있었다. 이에 본 연구는 새로운 별 표시 호텔등급제도에서 성공적으로 호텔등급을 획득한 사례분석을 통해 성공요인을 도출하고 시사점을 제공하고자 한다. 본 연구에서 도출된 등급획득의 성공요인은 첫째, 최고 경영진의 등급심사에 대한 높은 관심도와 호텔등급심사 준비를 위한 충분한 지원이 있었다는 점, 둘째, 새로운 호텔등급심사제도에서 요구하는 업장과 시설을 확보하였다는 점, 셋째, 내부적인 서비스 품질관리의 일관성을 유지했다는 점, 넷째, 외부업장의 위생 및 서비스가 잘 관리되고 있었다는 점이다. 위와 같은 연구결과를 바탕으로 호텔등급심사를 준비 중인 호텔의 경영진와 실무자들에게는 첫째, 객관적인 서비스 모니터링 체계를 구축할 것, 둘째, 한국관광공사의 사전컨설팅을 잘 활용할 것, 셋째, 안전과 위생에 대한 준비를 철저히 할 것을 제언하고자 한다. Hotel rating system plays a role of not only providing customers with crucial information regarding service quality and appropriateness of prices, but also hotels with promotion tools by assuring service level in public. Recognizing the fairness problems of old system, government introduced a star-symbolized national hotel rating system in 2015 which made obligation of hotel rating, entitled Korea Tourism Organization as rating agency, adopted rule of mystery shopper in test, and classified service-level conditions. The goal of this research is to identify success factor for obtaining desired rating based on case analysis and the result shows the significance of top management’s attention and willingness, preparations of required facilities, amenities, and shops, and consistency in the control of internal as well as external service quality.

우리나라의 공유민박업 도입에 관한 연구

유민석(Yoo, Min-seok) 가천대학교 아시아문화연구소 2018 아시아문화연구 Vol.46 No.-

공유민박업이라는 새로운 사업영역이 발달함에 따라서, 세계 각 국은 관련법률제정을 통해서 이를 제도권으로 받아들이고 이로 인한 피해를 줄이기 위한 최적의 방안을 찾으려 노력하고 있다. 공유민박을 허용하지만, 신고의무 부과, 영업일수 제한, 위반 시 제재 등이 최근의 일반적인 흐름이다. 이에 따라 가장 최근에 공유민박업과 관련한 법률을 제정하였으며, 국가적인 차원에서 법률로 도입한 일본의 ‘주택숙박사업법’에 대한 연구를 통하여, 우리나라의 공유민박업 도입과 시행을 위한 시사점을 찾아보고자 하였다. 연구결과에 따라 우리나라의 공유민박업 관련 법률에서 개선이 필요한 점은 첫째, 공유민박업 운영자에 대한 자격조건을 강화하여 성범죄자로 처벌을 받은 자를 징역, 벌금형, 치료감호 등으로 세분화하여 치료감호 이외의 처분을 받은 성범죄자들은 10년간은 공유민박업을 운영할 수 없도록 자격조건을 제한하는 것으로 개선할 필요가 있을 것이다. 둘째, 다른 숙박업소에 비하여 화재와 재난에 취약하며, 숙박업소의 위치 찾기가 불편한 공유민박업의 특성을 감안하여, 해당 법률에서 공유민박업 시설에 대한 물적요건을 좀 더 구체적으로 명시하도록 개선할 필요가 있다고 생각된다. 셋째, 서비스의 전문성이 다른 숙박업소에 비하여 취약할 수 있다는 점을 고려하여, 소비자들에게 좀 더 양질의 서비스를 제공하기 위하여 우리나라의 법률에서도 서비스 기준에 대한 명시적인 부분을 강화하는 것으로 개선할 필요가 있다고 생각된다. 넷째, 공유민박 중개업자에게 등록된 공유민박시설업자를 관리하도록 의무를 부여하여 공유민박업 등록여부를 반드시 확인하고, 등록업체만 중개할 수 있도록 개선할 필요가 있다고 생각된다. 만일 이에 따르지 않을 경우에는 제재를 가하는 것도 필요할 것이다. 공유민박업이 공유경제의 취지에 부합되고, 이로 인한 피해를 줄이기 위해서는 공유민박업의 시설과 서비스에 대한 자율 개선을 위하여 현재 실시되고 있는 관광품질인증제도에 향후 공유민박업을 포함하는 것도 검토할 필요가 있을 것이다. 또한 공유민박업에 대한 등급제도 도입도 검토해볼 수 있을 것이다. As House Sharing business is appeared upon IT development, many countries intend to seek the optimal conditions to reduce damage in existing industry as an establishment of related legislation. It is general trend to impose restictions on House sharing Business recently, such as limited business days, reporting obligations, penality for violation etc., Japan is a major competitor to attact foreign tourists in Korea, and recently enacted legislation related to house sharing business. Therefore, The purpose of this research is comparing and analyzing the House sharing business law between Japan and Korea to find out the improvement for accepting house sharing business in Korea. According to the results of the research, it is considerable to improve the house sharing business law as below. First, It is necessary to strengthen in the qualification conditions against punished with imprisonment for sex offenders as house sharing business operator. Second, It is required to strengthened house sharing business operator’s obligation to inform detailed conditions in accommodations and facilities. Third, It is required to strengthen house sharing business operator’s provided service standard to keep the service quality. Fourth, it is necessary to put housesharing business broker under an obligation to manage house sharing business operators for checking registration status. And this research suggested additionally to make the house sharing business meets the purpose of sharing economy as below. First, It is important to keep strict control the available gross area for House sharing business at Law. Second, it will considerable that House Sharing business include K-Quality system in tourism later.

원형 탈모증의 냉동치료요법

이범주(Beom Joo Lee),이원수(Won Soo Lee),유민석(Min Seok Yoo),안성구(Sung Ku Ahn) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.3

Background: 1. Conventional topical treatments of alopecia areata such as intralesional injection and topical application of glucocorticosteroids, and induction of conttact sensitivity using DPCP have had dieadvantages as follow 1) a time -consuming treatment perioed 2) various forms of discomfort during and after treatment 3) many side effects. 2. Though hair follicllee are easily damaged by intense cryo-application, we anticipate the regrowth of hair without damage to the tissue when applied to the scalp lightly Object : We evaluated the efficacy of treatment and side effect of cryotherapy in patients with alopecia areata and whether this method can be used for the firstiline treatment of small alopecic patches, avoiding the above disadvantages of conventional methods Method : 19 patients witt alopecia areata lesion(s) confined within one fourth of the totaI scalp area were treated by dip-stick method with liquid nitrogen once a week luring the first 4 weeks, then at a two week interval. A cotten tip was lightly applied to the alopecic, patches for one to two seconds. We surveyed side effects and regrowth of hair during a periodic follow up. Result : The results can be summurized as follows : 1. Therapeutic responses were noted in 17(89%) of 19 patients studid. 2. In all the patients who responded, vellus hair appeared within 4 weeks of treatment, and terminal hair appeared within 6 weeks of treatment. 3. There were no specific fectors showing statistical significance between therapeutic responses. 4. There were no significanf, side effects except very faint pain during cryoapplication. 5. Recurrence was observed in only patieni during a 9-12 months follow-up Conclusion : Cryotherpy of the alopecia areata can be regarded as an effective mode of treatment with many advantages. These include relatively good therapeutic results, short-term treatment, a simple and convenient method, and nearly no side effects. We recommerld cryotherapy as a first-line mode of treatment of alopecia area.ta lesions which are small in size and few in number. (Kor J Dermatol 1994; 32(3): 416-420)

미세변화신증에서 스테로이드 감량 중 발생한 심장내 혈전을 동반한 폐색전증

이세진 ( Se Jin Lee ),박지영 ( Ji Young Park ),유승기 ( Sung Kee Ryu ),최재웅 ( Jae Woong Choi ),채원영 ( Won Young Chae ),류희윤 ( Hee Yun Ryu ),유민석 ( Min Seok Yoo ),박윤석 ( Yoon Suk Bak ) 영남대학교 의과대학 2016 Yeungnam University Journal of Medicine Vol.33 No.1

Nephrotic syndrome is associated with a hypercoagulable state, which results in thromboembolism as one of its main complications. Various pathogenetic factors that cause the hypercoagulable state in nephrotic syndrome have been recognized. We report on a 19-year-old female with a minimal-change disease who developed pulmonary thromboembolism combined with intracardiac thrombus while on tapering steroid. Our patient showed hypoalbuminemia with an episode of shock, and was successfully treated with thrombolysis and anticoagulation therapy.