인간태아에서의 방사선효과

유동수,Yu, Dong-Su 대한치과의사협회 1980 대한치과의사협회지 Vol.18 No.8

신뢰성공학의 소개

유동수,Yu, Dong-Su 한국플랜트학회 2011 플랜트 저널 Vol.7 No.4

엽록체 유전정보를 이용한 두류 유전자원 형태적 형질의 유전력 분석

유동수,최유미,왕샤오한,강만정,Dong Su Yu,Yu-Mi Choi,Xiaohan Wang,Manjung Kang 한국자원식물학회 2023 한국자원식물학회지 Vol.36 No.4

Developing and breeding improved legume-based food resources require collecting useful genetic traits with heritability even though requiring some time-consuming, costly, and labor intensive. We attempted to infer heritability of nine genetic traits-days to flowering, days to maturity, period from flowering to maturity, the number of seeds per pod, 100-seeds weight, and four contents such as crude protein, crude oil, crude fiber, and dietary fiber-using 455 homologous chloroplast gene sets of six species of legumes. Correlation analysis between genetic trait differences and phylogenetic distance of homologous gene sets revealed that days to flowering, the number of seeds per pod, and crude oil content were influenced by genetic factors rather than environmental factors by 62.86%, 69.45%, 57.14% of correlated genes (P-value ≤ 0.05) and days to maturity showed intermediate genetic effects by 62.42% (P-value ≤ 0.1). The period from flowering to maturity and 100-seeds weight showed different results compared to those of some previous studies, which may be attributed to highly complicated internal (epistatic or additive gene effects) and external effects (cultural environment and human behaviors). Despite being slightly unexpected, our results and method can widely contribute to analyze heritability by including genetic information on mitochondria, nuclear genome, and single nucleotide polymorphisms.

향상된 미생물 유전체 주석 처리를 위한 단백질 발현 유전자 및 위유전자 판별 알고리즘

유동수(Dong Su Yu),정해영(Haeyoung Jeong),김병권(Byung Kwon Kim),송주연(Ju Yeon Song),이대희(Dae-Hee Lee),공은배(Eun Bae Kong),김지현(Jihyun F. Kim) 한국정보과학회 2012 정보과학회논문지 : 소프트웨어 및 응용 Vol.39 No.2

차세대 염기서열 해독 기술에 의해 해독되는 미생물 유전체의 수가 급증하고 있는 가운데, 자동화된 주석 처리 시스템은 수많은 유전체 정보를 처리하는 점에서 더욱 더 주목되고 있다. 해독된 미생물 유전체를 주석 처리하는 과정에서 주석 처리 결과의 민감도(sensitivity) 향상을 위하여 두 개 이상의 유전자 예측 프로그램을 사용하는 것이 효과적이지만, 잘못 예측된 유전자의 수가 증가하여 낮은 특이도(specificity)와 정확도(accuracy)를 보이는 문제가 있다. 많은 주석 처리 시스템은 예측된 유전자로부터 단백질을 암호화하는 유전자(coding sequence)와 위유전자(pseudogene)를 구분하지 않기 때문에 주석 처리 결과의 질적 향상을 위해 전문가들이 수작업으로 주석 내용을 수정하고 있는 것이 현실이다. 본 논문에서는 두 개 이상의 프로그램에 의해 예측된 유전자들 중에서 정확한 유전자를 구분하고, 위유전자를 예측하여 미생물 유전체 주석 처리 결과의 질적인 향상에 기여할 수 있는 GeneCuraid 알고리즘을 소개한다. 대장균 K-12 MG1666 유전체 염기서열을 대상으로 GeneCuraid 알고리즘을 시험한 결과, 98.09% 민감도, 24.33% 특이도 그리고 91.90%의 정확도를 보임으로써, CRITICA, GLIMMER, GeneMarkS, 그리고 AutoFACT 프로그램으로 구성한 주석 시스템의 결과보다 더 높게 나타났다. 따라서 GeneCuraid 알고리즘은 정확한 단백질 발현 유전자를 구분하고 위유전자를 예측함으로써 해독된 유전체 주석의 질을 더욱 향상시키고, 정확한 단백질 발현 유전자 및 위유전자를 수작업으로 결정하는데 소비되는 많은 시간과 비용을 절감시킬 것으로 기대된다. As more and more microbial genomes are being sequenced by next-generation sequencing technologies, automated genome annotation systems have become more important to process a vast amount of genome sequence information. The usage of multiple gene prediction programs warrants higher sensitivity, but this approach is ineffective in terms of specificity and accuracy because of increasing false positives. Furthermore, since many automated genome annotation systems do not distinguish pseudogenes from functional genes, manual curation is necessary to ensure high-quality annotation which is time-consuming and not always feasible. We developed GeneCuraid that aids the high confidence curation of protein-coding sequences and pseudogenes from genes predicted by automatic annotation tools. When the genome sequence of Escherichia coli K-12 MG1666 was used as a test data set, the algorithm improved specificity and accuracy of the annotation results were 24.33% and 91.90%, while maintaining sensitivity as high as 98.09%. Therefore, we expect that GeneCuraid algorithm would attain the high-quality genome annotation and help to reduce time and cost in manually determining correct protein-coding genes and pseudogenes.

RCP 시나리오기반 평균기온, 적산온도 불확실성 보완 프로그램

유동수(Yu, Dong-Su),권오창(Kwon, Oh-Chang),김홍기(Kim, Hong-Gie) 한국기후변화학회 2020 한국기후변화학회지 Vol.11 No.2

cacGMS: 특성평가 정보기반 식물 유전자원 군집 알고리즘

유동수(Dong Su Yu),강만정(Manjung Kang),노나영(Nayoung Ro),허온숙(Onsook Hur) 한국육종학회 2022 한국육종학회지 Vol.54 No.2

Plant germplasm is a part of living genetic resources, including seeds and plant materials, such as roots, leaves, and stems, and should be conserved and managed to maintain ecological biodiversity and to consistently generate the product and supply food crops. Plant germplasm can be categorized based on various genetic traits such as race, and clustering based on similar genetic traits is an efficient method for managing large numbers of germplasms. Therefore, we developed an algorithm, termed cacGMS (Clustering Analysis for Categorical genetic traits of germplasms in Genebank Management System), using categorical variables which statistically differentiate the datatype of genetic traits such as seed-coat color, seed shape, and flower color. Briefly, using Newman’s modularity method, cacGMS combines the hierarchical clustering algorithm using the Ward2 method and representative-based algorithms such as K-medoids, and it regroups all germplasms using germplasm core sets. We tested cacGMS using 2,378 pepper germplasms with 46 different categorical genetic traits, and it exhibited better performance than the hierarchical and K-medoids algorithms for the average distance among clusters (0.4534) and entropy (1.2672). Moreover, cacGMS showed better performance in terms of threshold (from 15 to 30) for genetic traits than other algorithms and provided similar results in a test run using tomato germplasm. From these results, we expect that cacGMS will be a useful tool for managing each group with numerous plant germplasms and facilitate the analysis of other studies, such as analysis of representative characteristics of clustered germplasms and of correlations among germplasms in a particular cluster.

전국 야생 벌목 분포에 대한 기후요인 영향 연구

유동수 ( Dong-su Yu ),권오창 ( Oh-chang Kwon ),신만석 ( Man-seok Shin ),김정규 ( Jung-kyu Kim ),이상훈 ( Sang-hun Lee ) 한국환경생태학회 2022 한국환경생태학회지 Vol.36 No.3

온실가스 배출 증가에 의한 기후변화는 화분매개곤충과 식물과의 생태적 상호작용인 수분생태계와 농업생태계를 포함한 자연생태계를 변화시킬 수 있다. 특히 수분생태계에서 중요한 야생벌(wild bee)은 기후변화에 의해 감소되고 있어서 결국 농업경제, 현화식물의 생태활동, 나아가 전체 생물종 다양성에 악 영향을 끼치고 있음이 보고되고 있다. 따라서 지구온난화에 의해 한반도(남한)에서도 매년 기온이 상승하고 있고, 그에 따른 기후변화 발생으로 한반도 내 야생벌의 생태활동에 영향을 주고 있음을 예상할 수 있다. 본 연구에서는 한반도(남한)에서 출현하는 야생벌(꿀벌상과, 말벌상과, 청벌상과)의 분포와 기후요인과의 관계를 검정하기 위하여, 2017년(37 조사지점)에서 2018년 (14 조사지점) 까지 총 51개 조사지점을 대상으로 말레이즈 트랩을 이용하여 야생벌류의 출현현황을 파악하였다. 형태 및 문헌을 통해 동정한 야생벌류와 산림기후대에 따른 분포는 평균기온, 적산온도와 상관성이 있음을 확인하였다. 이러한 결과를 바탕으로 공통사회 경제경로(Shared Socioeconomic Pathways, SSP) 시나리오의 2-4.5와 5-8.5버전으로 BIOMOD 종분포 모형에 따라 남한 전역에서 출현한 야생벌과 기후대별로 특이적으로 출현한 종의 서식지 분포 변화를 예측하여 현재의 종 서식지 분포에서, 2050년과 2100년에 북쪽으로 서식지가 이동함을 확인하였다. 이를 통해 향후 지구온난화가 지속될 경우 국내 야생벌의 분포 변화가 일어 날 수 있고, 그로 인한 한반도의 생태계 변화가 야기될 수 있음을 예측할 수 있었다. 본 연구결과는 기후변화에 따른 수분생태계 및 그와 관련된 영향에 대한 연구와 야생벌 관리를 위한 정책수립을 위해 참조할 수 있는 연구자료가 될 수 있을 것으로 기대하고 있다. Climate change caused by increased greenhouse gas emissions can alter the natural ecosystem, including the pollination ecosystem and agricultural ecology, which are ecological interactions between potted insects and plants. Many studies have reported that populations of wild bees, including bees and wasps (BW), which are the key pollinators, have gradually declined due to climate change, leading to adverse impacts on overall biodiversity, ultimately with agribusinesses and the life cycle of flowering plants. Therefore, we could infer that the rising temperature in Korean Peninsula (South Korea) due to global warming has led to climate change and influenced the wild bee’s ecosystem. In this study, we surveyed the distributional pattern of BW (Superfamily: Apoidea, Vespoidea, and Chrysidoidea) at 51 sites from 2017 (37 sites) to 2018 (14 sites) to examine the effects of climatic factors on the nationwide distribution of BW in South Korea. Previous literature has confirmed that their distribution according to forest climate zones is significantly correlated with mean and accumulative temperatures. Based on the result, we predicted the effects of future climate changes on the BW distribution that appeared throughout South Korea and the species that appeared in specific climate zones using Shared Socioeconomic Pathways (SSPs). The distributions of wild BW predicted by the SSP scenarios 2-4.5 and 5-8.5 according to the BIOMOD species distribution model revealed that common and endemic species will shift northward from the current habitat distribution by 2050 and 2100, respectively. Our study implies that climate change and its detrimental effect on the ecosystem is ongoing as the BW distribution in South Korea can change, causing the change in the ecosystem in the Korean Peninsula. Therefore, immediate efforts to mitigate greenhouse gas emissions are warranted. We hope the findings of this study can inspire further research on the effects of climate change on pollination services and serve as the reference for making agricultural policy and BW conservation strategy

피부 점액성 에크린 암 1예

황종익 ( Jong Ik Hwang ),유동수 ( Dong Su Yu ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.5

Mucinous eccrine carcinoma of the skin is a rare skin adnexal malignant tumor that origins from mucin-secreting dark cells, and it arises from the deepest portion of eccrine ducts. It usually affects people in their fifth to seventh decades of life and it predominantly occurs in men. It appears to exhibit a predilection for the head and neck. The histopathologic characteristics are a large mucinous pool with fibrous septae and clusters of tumor cells. The treatment of choice is surgical removal. We present here the case of a patient with a mucinoous eccrine carcinoma on the infraorbital area of the right side of his face and we review the related literature. (Korean J Dermatol 2009;47(5):618~620)

점봉산 시험림 지역의 지오톱 분류와 지형다양성 연구

김남신 ( Nam Shin Kim ),한동욱 ( Dong Uk Han ),차진열 ( Jin Yeol Cha ),권혜진 ( Hye Jin Kwon ),조용찬 ( Yong Chan Cho ),오승환 ( Seung Hwan Oh ),유승화 ( Seung Hwa Yoo ),유동수 ( Dong Su Yu ),박용수 ( Yong Su Park ) 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2015 한국환경복원기술학회지 Vol.18 No.6

This study was carried out to suggest fundamental concepts and data ideas for biodiversity and confrontation strategy on global environmental changes by analyzing geomorphic milieu and geotop in Mt. Jeombong experimental forest. Elements of landform were classified as landform sets by scale. Scale for classification could be decide on four categories. We could classify landforms which scale zero is seven elements, scale one is twelve elements, scale two is fifteen elements, scale three is twenty nine elements. Especially mountain wetlands were classed as valley and channel types in Mt. Jeombong. Geotop by clustering methods could be four spatial units as 2, 3, 5, and 7 classes, and analyzed geodiversity as landform sets for explanation of vegetation distribution. Rate of rise of temperature was 0.031°C per year, change ratio was increased 1.25°C, and also precipitation was increased 320mm during forty year(from year 1973 to year 2012). The result of this research can be affordable to provide information for forest management of mountainous areas.

얼굴에 피부전이를 보인 외투막 세포(Mantle Cell) 림프종

이준영 ( Jun Young Lee ),김희수 ( Hee Su Kim ),박훈 ( Hoon Park ),김진우 ( Jin Woo Kim ),유동수 ( Dong Su Yu ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.6

Mantle cell lymphoma (MCL) is an uncommon and aggressive form of non-Hodgkin lymphoma and this typically involves lymph nodes. Extranodal involvement is frequent and especially in the bone marrow, spleen, gastrointestinal tract and Waldeyer`s ring. MCL is not well represented in the dermatology literature because the skin is rarely involved. We describe here a case of relapse of MCL that was diagnosed by skin metastasis of the face. A 71 year-old male patient presented with erythematous nodules that had been on the Rt. forehead for 6 months. The patient was initially diagnosed as having MCL and he had undergone chemotherapy. A year after complete remission, multiple nodules developed on the forehead. Biopsy of the nodule revealed skin metastasis of MCL. (Korean J Dermatol 2011;49(6):511∼515)