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RISS 인기검색어
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- 저자 : 유경자(KZ Ryu) (검색결과 2 건)
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차광열(KY Cha),유경자(KZ Ryu),한혁동(HD Han),송찬호(CH Song),곽현모(HM Kwak) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.9
생후 3일에서 7일 사이의 신생아 79명을 대상으로 하여 혈청내 T4및 TSH치를 측정하여 다음과 같은 결과를 얻었다. 1.신생아 T4의 평균치는 9.44+-0.29ug/100ml를 나타내었으며 전체의 94.9% (75명)이 성인의 T4 정상치인 5~13ug/100ml에 속하는 것을 알 수 있다. 2.신생아 TSH의 평균치는 4.23+-1.56uIU/ml를 나타내었으며 전체의 96.3%(76명)가 성인의 TSH 정상치인 10uIU/ml이하를 보임을 알 수 있다. 3.신생아의 성별 T4, TSH의 평균치를 비교하여 볼 때 통계학적으로 유의한 차이는 없었다. 4.신생아의 체중별 T4, TSH의 평균치를 비교하여 볼 때 통계학적으로 유의한 차이를 볼 수 없었다. The incidence of congenital hypothyroidism is about 1 in 7,000 (Hobel, 1980) and it is believed to be an cause of the mental ratardarton. Early diagnosis and treatment of congenital hypothyroidism is critical to the prevention of severe mental retardation. Thus, there is a need for further study and improvement in screening tests of hypothyroidism. This study was conducted to evaluate values of serum T4 and TSH in Korean neonates at the age of 3~7 days. Seventy-nine neonates were recruited from Department of Obstetrics and Gynecology, Yonsei University College of Medicine and Jeil Hospital. Serum T4 and TSH values were measured by specific and sensitive radioimmunoassay. Results obtained are as follows: 1.The average T4 value was 9.44+-0.29ug/100ml. T4 values obtained from 43 neonates (54.4% of the total sample population) were in 9.0~10.9ug/100ml, which was highest distribution of neonates. 2.THe average TSH value was 4.23+-1.56uIU/100ml. TSH values obtained from 24 neonates (30.3% of total sample population) were in 2.0~2.9uIU/ml, which was highest distribution of neonates. 3.There was no sex difference in serum T4 and TSH values in male and female neonates. 4.No significant correlation was observed between birthweight and serum T4 and TSH values in Korean neonates. It might be, therefore, concluded that serum levels of T4 and TSH in 3~7 days Korean neonates were not significantly different from normal values of Korean adult and there were no sex and weight differences in serum T4 and TSH of Korean neonates.
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흰쥐에서 난소제거가 Follocle Stimulating Hormone (FSH) 분비와 FSHβ Subunit mRNA에 미치는
송찬호,김재욱,박기현,조동제,유경자,이병석,윤미정,김창미 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.8
Follicle stmulating hormone ( FSH ) consist of α and β subunits, which are encoded by se-parate genes. Pituitary release of FSH appears to be regulated by the hypothalamic GnRH and the gonadal steroid hormones. In addition , inhibin and follistatin produced by the gonad have been known to inhibit FSH secretion selectively. However , little is known about their regulation of the biosynthesis of FSH subunits at transcriptional and posttranscriptional levels. In the pre-sent study , we studied the time course of changes in α and FSHβ subunit mRNA concentrati-ons after castration and the effects of ovarian steroids of changes in α and FSHβ subunit mRNA concentrations after castration and the effects of ovarian steroids on α and FSHβ subunit mRNA in ovariectomized rats in order to determine Whether FSH subunit synthesis is modulated at the pretranslational levels, and whether synthesis and secretion are differently regulated. Results are as follows: 1. The time course of the rise in the steady state α subunit and FSHβ subunit mRNA levels were observed after ovariectomy, which paralleled the increases in serum and pituitary FSH concentrations. The time course experiments revealed differences in the patterns of α and FSHβ subunit mRNA responses , the rise in FSHβ subunit mRNA levels being more pro- minent than the rise in α subunit mRNA. 2. FSHβ mRNA levels were negatively regulated by the single injection of progesterone but not by estradiol , suggesting that FSHβ subunit mRNA seemed to be more sensitive to ne-gative feedback by progesterone than estradiol. Similar results were obtained by the continuous treatment of ovarian steroids for 1∼4 days , but inhibition was more prominent with continuous treatment. It is , therefore , concluded that estradiol and progesterone inhibit the synthesis of FSH at the pretranslational level by modulating the steady state levels of α and FSHβ subunit mRNA , progesterone effect being more promiment than that of estradiol and α and FSHβ subunit are regulated in a different manner.
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