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김성환,김미금,위원랑 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.5
Purpose: To investigate the additive effect of oral steroid with topical nonsteroidal anti-inflammatory drug(NSAID) on cystoid macular edema (CME) in patients with epiretinal membrane (ERM) after cataract surgery. Methods: Medical records of subjects who underwent uneventful cataract surgery (n = 1,349) were retrospectivelyreviewed; among these patients, those with pre-existing ERM (n = 81) were included. Patients were dividedinto two groups: one group had postoperative administration of oral steroid for 1 week (n = 45) and theother group did not have oral steroid administration (n = 36). Changes in macular thickness and incidence ofCME were compared in both groups. Topical NSAIDs were administered in both groups for 1 month postoperatively. Definite CME and probable CME were defined by changes in retinal contour with or without cystoidchanges. Change in central macular thickness of more than three standard deviations (≥90.17 μm) was definedas possible CME. Macular thickness was measured at 1 month after the operation by optical coherencetomography. Results: The incidence of definite, probable, and possible CME were 2.22%, 4.44%, and 8.89% with the use ofsteroid and 2.78%, 5.56%, and 8.33% without steroid, respectively (p = 0.694, p = 0.603, and p = 0.625), andregardless of treatment group, the incidences in these patients were higher compared to incidences in wholesubjects (1.26%, 2.30%, and 4.32%; p = 0.048, p = 0.032, and p = 0.038, respectively). The differences inmacular thickness were not statistically different between the two groups. Average changes of central fovealthickness in 3 mm and 6 mm zone were 29.29 μm, 35.93 μm, and 38.02 μm with the use of steroid and 32.25μm, 44.08 μm, and 45.39 μm without steroid (p = 0.747, p = 0.148, and p = 0.077, respectively). Conclusions: This study suggests that administration of oral steroid may not have a synergistic effect in reductionof CME and retinal thickness in patients with pre-existing ERM after cataract surgery, when topicalNSAIDs are applied.
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이현일,김미금,고정화,이현주,위원랑,이진학 대한의학회 2007 Journal of Korean medical science Vol.22 No.3
To investigate if the surface modification of intraocular lens (IOL) is efficient in the prevention of posterior capsular opacification (PCO), the acrylic surface of intraocular lens (Acrysofဂ) was polymerized with polyethylene glycol (PEG-IOL). The human lens epithelial cells (1×104 cells/mL) were inoculated on PEG grafted or unmodified acrylic lenses for the control. The adherent cells on each IOL surface were trypsinized and counted. The every PEG-IOL was implanted in 20 New Zealand rabbits after removal of crystalline lens. The formations of PCO were checked serially through retroilluminated digital photography, and the severity scores were calculated using POCOmanဂ. The cell adherence patterns on each IOL were examined by scanning electron microscopy. As a result, the mean number of adherent cells of PEG-IOL (3.2±1.1×103) tended to be smaller than that of the acrylic controls (3.6±1.9×103) without a statistical significance (p=0.73). However, the mean severity of PCO formation in PEG-IOL was significantly lower than that in the control during the third to sixth weeks after surgery. Scanning electron microscopy revealed that the more patch-like cells were found firmly attached to the IOL surface in control than in the PEG-IOL. Conclusively, PEG polymerization to the acrylic IOL would possibly lessen the formation of PCO after cataract removal.
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