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- 저자 : 우수미 ( Su Mi Woo ) (검색결과 4 건)
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급성췌장염의 중증도 예측에 대한 혈청 Procalcitonin의 효용성 및 절단값
우수미 ( Su Mi Woo ),노명환 ( Myung Hwan Noh ),김병근 ( Byung Geun Kim ),형건덕 ( Chien Ter Hsing ),한지선 ( Ji Sun Han ),유승희 ( Seung Hee Ryu ),서정민 ( Jeong Min Seo ),윤현아 ( Hyun Ah Yoon ),장진석 ( Jin Seok Jang ),최석렬 ( 대한소화기학회 2011 대한소화기학회지 Vol.58 No.1
Background/Aims: The aim of this study is to assess serum procalcitonin (PCT) for early prediction of severe acute pancreatitis compared with multiple scoring systems and biomarkers. Methods: Forty-four patients with acute pancreatitis confirmed by radiological evidences, laboratory assessments, and clinical manifestation were prospectively enrolled. All blood samples and image studies were obtained within 24 hours of admission. Results: Acute pancreatitis was graded as severe in 19 patients and mild in 25 patients according to the Atlanta criteria. Levels of serum PCT were significantly higher in severe acute pancreatitis (p=0.001). The accuracy of serum PCT as a predicting marker was 77.3%, which was similar to the acute physiology and chronic health examination (APACHE)-II score, worse than the Ranson score (93.2%) and better than the Balthazar CT index (65.9%). The most effective cut-off level of serum PCT was estimated at 1.77 ng/mL (AUC=0.797, 95% CI=0.658-0.935). In comparision to other simple biomarkers, serum PCT had more accurate value (77.3%) than C-reactive protein (68.2%), urea (75.0%) and lactic dehydrogenase (72.7%). Logistic regression analysis revealed that serum PCT has statistical significance in acute severe pancreatitis. Assessment of serum PCT levels and length of hospital stay by simple linear regression analysis revealed effective p-value with low R square level, which could make only possibilty for affection of serum PCT to admission duration (r2=0.127, p=0.021). Conclusions: Serum PCT was a promising simple biomarker and had similar accuracy of APACHE-II scores as predicting severity of acute pancreatitis. (Korean J Gastroenterol 2011;58:31-37)
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감염 ; 폐외 결핵 진단에서 2개의 전혈 인터페론 감마 측정법의 유용성 비교
한송이 ( Song Yee Han ),이혁 ( Hyuck Lee ),정동식 ( Dong Sik Jung ),김경희 ( Kyeong Hee Kim ),우수미 ( Su Mi Woo ),박소영 ( So Young Park ),서정민 ( Jeong Min Seo ),정진규 ( Jin Kyu Jung ),윤늘봄 ( Neul Bom Yoon ),이성우 ( Sung W 대한내과학회 2011 대한내과학회지 Vol.81 No.4
목적: QuantiFERON-TB GOLD (QFT-G)와 QuantiFERON-TB GOLD in tube (QFT-IT) 검사는 주로 활동성 폐결핵 또는 잠복결핵의 진단과 관련되어 연구되어져 왔으나, 폐외 결핵의 진단과 유용성은 아직 잘 밝혀지지 않은 상태이다. 본 연구는 폐외 결핵 환자에서 QFT-G와 QFT-IT의 진단적 유용성에 대해 비교 분석하였다. 방법: 2007년 6월부터 2010년 8월까지 임상적으로 폐외결핵이 의심되어 QFT-G, QFT-IT 검사를 한 환자 각각 56명과 48명을 대상으로 하였다. QFT-G와 QFT-IT의 민감도, 특이도, 양성예측도, 음성예측도와 QFT-IT의 cut-off value를 통하여 진단적 유용성을 분석하였다. 결과: 폐외 결핵으로 진단된 환자는 55명(53%)이었고 QFT-IT의 민감도, 특이도, 양성예측도, 음성예측도는 96%, 42%, 62%, 91%이었으며, QFT-G는 81%, 52%, 68%, 68%이었다. 감염부위에 따른 검사 결과 또한 민감도, 음성예측도에서 QFT-IT가 QFT-G보다 더 높은 결과를 보였다. 본 연구에서 cut-off value는 기존에 권고하고 있는 cut-off value의 범위 안에 포함되었다(0.30-0.45 IU/mL, sensitivity 95.8%, specificity 41.7%). 결론: QFT-IT는 M.tuberculosis 감염의 진단에 있어서 QFT-G보다 높은 민감도와 음성예측도를 보이며, 특이도에 있어서는 유사한 결과를 보여 새로운 IGRA방법으로서 폐외결핵의 진단을 더 강화시킬 수 있는 가능성을 보여주었다. Background/Aims: The QuantiFERON-TB Gold (QFT-G) and QuantiFERON-TB Gold in tube (QFT-IT) assays have been studied primarily for the use of diagnosing active pulmonary tuberculosis (TB) or latent TB. The clinical usefulness of these assays for the detection of active extrapulmonary (EP) TB has not been fully defined. The aim of this study was to compare the diagnostic value of these two interferon-gamma assays for EP-TB. Methods: From June 2007 to August 2010, we evaluated the usefulness of QFT-G (n=56) and QFT-IT (n=48) in patients (n=104) with suspected EP-TB. The diagnostic sensitivity, specificity, postive predictive value (PPV), and negative predictive value (NPV) of QFT-G and QFT-IT, and the cut-off value of QFT-IT were analyzed. Results: EP-TB was diagnosed in 55 (53%) patients. The overall sensitivity, specificity, PPV, and NPV of the QFT-IT assay were 96%, 42%, 62%, and 91%, respectively, and those of the QFT-G test were 81%, 52%, 68%, and 68%, respectively. In subgroup analyses according to infection site, the sensitivity and NPV of QFT-IT were higher than those of QFT-G. Analysis confirmed that the manufacturer`s recommended test cut-off value fell within our cut-off value range (0.30-0.45 IU/mL; 95.8% sensitivity, 41.7% specificity). Conclusions: The QFT-IT assay showed superior sensitivity and NPV, and equivalent specificity, as comparison with the QFT-G test for the detection of Mycobacterium tuberculosis infection. The logistic benefits of the QFT-IT test format should facilitate the diagnosis of EP-TB. (Korean J Med 2011;81:478-486)
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복합 항암요법으로 성공적으로 치료한 동시성 식도암과 위선암
한지선 ( Ji Sun Han ),최석렬 ( Seok Reyol Choi ),장진석 ( Jin Seok Jang ),노명환 ( Myung Hwan Roh ),김대철 ( Dae Cheol Kim ),유승희 ( Seung Hee Ryu ),우수미 ( Su Mi Woo ),형건덕 ( Chien Ter Hsing ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.2
Although cases of simultaneous esophagus and stomach cancer have been reported sporadically, there are rare reports of successful treatment using chemotherapy. We report a case of synchronous esophageal and gastric cancer successfully treated using docetaxel and cis-diammineedichloro-platinum (CDDP) combination chemotherapy instead of surgery. A 82-years-old man with anorexia and progressive weight loss was diagnosed with synchronous esophageal and gastric cancer by endoscopy. Both cancers were diagnosed as resectable by the preoperative clinical staging. However, surgery was contraindicated because of severe lung dysfunction. Moreover, he actively refused radiotherapy and endoscopic management. Therefore, the patient was given combined chemotherapy with docetaxel (65 mg/m2) and CDDP (60 mg/m2). The esophageal and gastric lesion completely disappeared on endoscopy, and there were no residual tumor cells on endoscopic biopsy after three cycles of chemotherapy. Metastatic lymph nodes also completely disappeared on the CT scan. The patient received a total of ten cycles of chemotherapy, without severe adverse effects. The patient remained asymptomatic for 18 months after discontinuation of the chemotherapy, without evidence of local recurrence or distant metastasis. Surgery or endoscopic treatment of both esophageal and gastric cancers is desirable, but, if medically inoperable, chemotherapy can be alternative treatment option. (Korean J Gastroenterol 2012;60:113-118)
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김광래,서주환,김상범,우수미,김정웅 경희대학교 부설 디자인연구원 1999 예술· 디자인학연구 Vol.2 No.1
Predicting tree-form should be very important, even though it is difficult, step for landscape designers. The terms 'form' and 'habit' are often used when talking about the appearance of plants. It will be helpful to attempt a definition of these two terms with respect to plants ; 'habit' can be described as the direction of growth, and 'form' as the mass contained within the extremities of growth. but the designers forget the important of 'habit'. The initial selection of plants is the deceive step in the ultimate success of any landscape design. This study was carried out the method to use data of landscape design by classifying 'form' and 'habit'. It is important to landscape designer to recognize the relationship between the rationality which prevails throughout the modern technical world and the intuitive aspects of design that are essential for developing creative solution to encourage creativity as well as analytical responsibility.
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