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오효원 ( Hyo Won Oh ),김영임 ( Young Im Kim ),최미혜 ( Mi Hye Choi ),박선화 ( Sun Hwa Park ),이흥수 ( Heung Soo Lee ) 대한예방치과·구강보건학회 2010 大韓口腔保健學會誌 Vol.34 No.2
Objectives. We measured the perception and attitudes of dental hygienists on a water fluoridation program because of their expertise on oral health challenges. Methods. We surveyed 363 dental hygienists working at dental care organization in Dae-jeon, Gun-san, Ik-san, and Jeon-ju cities. Results. Water fluoridation programs are not well understood with 16.8% of respondents indication a shortage or extreme shortage of understanding from education water fluoridation program leading to a lack of knowledge satisfaction on th program. The needs hygienist background and type of practice influenced program awareness. particularly marital status, hospital type and education completed. Dental hygienist that work aggressively for prevention also showed high levels of program awareness. The prevention of caries was most preferred training case. Conclusions. Education and awareness of the fluoride program should be increase nationally through preiodic domestic maintenance training and seminars for dental hygienists.
나자영,오효원,이흥수 대한예방치과·구강보건학회 2023 大韓口腔保健學會誌 Vol.47 No.1
Objectives: This study aimed to investigate the relationship between oral health beliefs and oral health-related dietary behavior. Methods: The participants of this cross-sectional study were 728 middle school students living in Jeonju who were selected through convenience sampling. For the survey, self-administered questionnaires were completed in individual settings. The analysis model was the oral health belief model, and the analysis method was path analysis. Results: Among oral health beliefs, perceived susceptibility, perceived severity, perceived barriers, and self-efficacy were found to be correlated with the oral health-related dietary behavior index. Multiple regression analysis showed that factors affecting the oral health-related dietary behavior index were gender (female), perceived susceptibility, perceived severity, perceived barriers, and self-efficacy. Path analysis showed that variables that significantly impact the oral health-related dietary behavior index are perceived susceptibility, perceived benefits, perceived barriers, and likelihood of action. The factor with the greatest impact was perceived barrier; the lower the barrier, the higher the level of dietary behavior undertaken to prevent dental caries. Conclusions: Oral health beliefs are related to oral health-related dietary behavior. Since perceived barriers had the greatest correlation with oral health-related dietary behavior, measures must be taken to help remove the barriers.
Streptococcus mutans 생물막 산생성에 대한 탄산음료의 영향
정희영,오효원,전재규 대한예방치과·구강보건학회 2023 大韓口腔保健學會誌 Vol.47 No.3
Objectives: The purpose of this study was to determine the influence of carbonated drinks on acid production in Streptococcus mutans biofilm. Methods: Fifty one hour-old S. mutans biofilms were formed on hydroxyapatite discs. After selecting of the carbonated drinks (Coca cola, Coca cola zero sugar, Sprite, Sprite zero sugar, and Fanta), as well as negative (water) and positive (1% sucrose) controls for this study, glycolytic pH drop assay was performed using the S. mutans biofilms. The influence of the test agents on acid production of the 51 h-old biofilms was determined by the initial production rate and final concentration of protons, calculated using the pH values at 0-30 min and 120 min, respectively. Results: The pH values of the carbonated drinks ranged from 2.4 to 3.1. Sugar-free carbonated drinks and the negative control maintained the pH of acid produced by S. mutans biofilms above thecritical pH. The sugar-added carbonated drinks and the positive control decreased the pH below the critical pH due to the acid production of S. mutans biofilms. Overall, sugar concentration in carbonated drinks was closely related to acid production in S. mutans biofilm. Conclusions: These results suggest that sugar-added carbonated beverages should be considered for their role in dental erosion and dental caries, while non-sugar-added carbonated beveragesshould emphasize their role in dental erosion rather than dental caries.
이금화,오효원,Hyun-Dae Lim,Wan Lee,채한정,Hyung-Ryong Kim 대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.6
High glucose leads to physio/pathological alterations in diabetes patients. We investigated collagen production in human gingival cells that were cultured in high concentrations of glucose. Collagen synthesis and secretion were increased when the cells were exposed to high concentrations of glucose. We examined endoplasmic reticulum (ER) stress response because glucose metabolism is related to ER functional status. An ER stress response including the expression of glucose regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), inositol requiring enzyme alpha (IRE-1α) and phosphor- eukaryotic initiation factor alpha (p-eIF-2α) was activated in the presence of high glucose. Activating transcription factor 4 (ATF-4), a downstream protein of p-eIF-2α as well as a transcription factor for collagen, was also phosphorylated and translocalized into the nucleus. The chemical chaperone 4-PBA inhibited the ER stress response and ATF-4 phosphorylation as well as nuclear translocation. Our results suggest that high concentrations of glucose-induced collagen are linked to ER stress and the associated phosphorylation and nuclear translocation of ATF-4.
다변량 분석기법을 이용한 한국 12세 아동의 우식패턴 분류
김인자,이흥수,오효원 대한예방치과·구강보건학회 2023 大韓口腔保健學會誌 Vol.47 No.3
Objectives: The purpose of this study was to analyze the pattern of dental caries in 12-year-oldKorean adolescents through multivariate analysis. Methods: This study used raw data from the 2015 Korea Children’s Oral Health Survey. The studyparticipants were 12-year-old adolescents. A total of 27,291 people participated in the questionnaire and oral test. The statistical analysis methods used were multidimensional scaling, clusteranalysis, and factor analysis. Results: The result was derived after analyzing the dental caries pattern of teeth and tooth surfaceby multi-dimensional scaling method, cluster analysis method, and factor analysis. Morphologicallyhomologous teeth were gathered to form clusters. Caries occurrence showed a more similar cariesexperience pattern when the types of tooth surfaces, such as occlusal and occlusal surfaces, werethe same than when they were different. Conclusions: Epidemiological data on the pattern of dental caries in 12-year-old adolescents can beused as basic data to create evidence-based dental caries management plans.
청소년에서 구강건강관련 자기효능감과 사회적 지지가 구강건강관련 삶의 질에 미치는 영향
최부영,이흥수,오효원 대한예방치과·구강보건학회 2023 大韓口腔保健學會誌 Vol.47 No.1
Objectives: This study aimed to examine the effects of oral health-related self efficacy and social support on oral health-related quality of life, and analyze the related factors. Methods: A cross-sectional study was carried out on 979 high school students living in Iksan. Data were collected from January 15 to 30, 2014. Individual self-administered surveys were conducted through the sampling method. The contents of the survey were the characteristics of the subjects, oral health-related self efficacy (OHSE), social support related to oral health (OHSS), and quality of life related to oral health (QHRQoL). A survey tool designed by the author was used to measure OHSE and OHSS. QHRQoL used Child Oral Health Impact Profile-Short Form 19 (COHIP-SF 19) for examination. The statistical analysis methods used were mean difference, correlation, and multiple regression analyses. Results: QHRQol was correlated with OHSE, but not OHSS. Per the multivariate analysis, factors that affected QHRQoL were gender, mother’s education level, academic stress, and OHSE; OHSS did not have any effect. Conclusions: It was found that OHSE influenced QHRQoL. Therefore, it is necessary to develop education programs that can enhance OHSE.
구강 불멸화 및 악성 구강 각화세포에서 일산화질소 유도 세포독성에 대한 Heme Oxygenase-1의 역할
이선경,이준,조이수,신형식,오효원,이화정,김희수,손태형,최희원,이제중,이종현,이병업,김민관,신미란,김은철 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.3
We have examined the effect of NO donor, S-nitl‘ oso-N-acetyl-DL-penicillamine(SNAP) on heme oxygenase-1 (HQ-l) ex pression in human oral immortalized & malignant keratinocytes, and investigated in the control of keratinocyte proliferation evidence tha t HO-1 cou ld be involved in a low dose of NO, NO inhibitor, HOinducer, and HO inhibitor medi ated cytoprotect ion against cytotoxi city induced by a high dose of NO Oral keratinocyte growth inhibitory or anti-proliferative effects were exerted by with SNAP and hemin in a dose- and cul tivation time dependent manner The level of HQ-1 protein was increased in all cell types after exposure hernin dose, and the hemin induced HQ-1 protein achieved at higher maximum level by 12 hrs in all kind of cells , The pretreatment of cells with 0, 2 μ M SNAP reduced 1 mM SNAP-induced death in IHOK and HN4 cells , These cytoprotective effects on high dose of NO induced HQ-1 expresion and cell ular toxicity were blocked by low dose of SNAP, HCB, and ZnPP IX supporting the involvement of HQ-1 in high dose NO induced growth arrest or cell death, But these cytoprotection pattern is different from immortalized and malignant keratinocytes , These results indirectly demonstrate that HQ-1 could be involved in cytoprotection by NO priming against high dose NO induced cytotoxicity in immortalized and maigla nt oral keratinocytes, Thus, HQ-1 might be an important cellular target of NO donor, with clinical implications for the pre vention of inJlammatory di seases and anti-tumor immunity