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제 2형 당뇨병 환자와 정상 성인의 비타민 A와 비타민 E 영양상태
오현미(Oh Hyun-Mee),윤지영(Yoon Ji-Young),조성희(Cho Sung-Hee),윤진숙(Yoon Jin-Sook) 韓國營養學會 2009 Journal of Nutrition and Health Vol.42 No.4
We evaluated the vitamin A and E status of type 2 diabetic patients and normal adults living in Daegu area. Dietary intakes for two non-consecutive days were measured by 24-hour recall method for 76 diabetic patients and 72 normal adults. Plasma levels of retinol and α-tocopherol were measured using HPLC method. Dietary intakes of vitamin A were not significantly different between the diabetic and the normal adults. However, the diabetic patients had significantly lower vitamin E intakes than the normal adults. Major food sources for vitamin A intake were red pepper powder and carrot. Half of the subjects from diabetic as well as normal adults consumed less than estimated average requirement of vitamin A. Plasma levels of retinol and tocopherol were maintained within normal ranges for most of the subjects regardless of diabetic status. Dietary intake of vitamin A was associated with vitamin E intake, however, there was no significant correlations between vitamin E intake and plasma α-tocopherol levels. It seems that diabetic patients should try to increase dietary intake of vitamin E, as prolonged lower-level intake of vitamin E could eventually lead to vitamin E depletion. Further studies are needed to identify the magnitude of dietary variance at individual and seasonal levels, and to understand the discrepancies in dietary intake and plasma levels before establishing the dietary reference intake based on Korean dietary pattern.
제 2형 당뇨병 환자에서 단기간 아연 보충에 따른 아연과 구리 영양상태
오현미(Hyun Mee Oh),윤진숙(Jin Sook Yoon) 대한지역사회영양학회 2009 대한지역사회영양학회지 Vol.14 No.2
This study was carried out to determine whether a short-term zinc supplementation could improve the zinc status without adverse changes in copper status among type 2 diabetic patients. Seventy-six diabetic subjects and 72 normal adults participated in this study. Subjects were randomly divided into supplemented and control groups. Forty-four diabetic patients and 34 normal subjects were supplemented with 50 mg zinc gluconate daily for 4 weeks. Dietary intakes of participants were measured for two non-consecutive days by 24-hour recall method. Nutritional status of zinc and copper were also evaluated by biochemical measurement of fasting plasma samples and spot urinary collection. At baseline, diabetic patients showed significantly lower levels of dietary zinc intake and higher urinary zinc excretion than the normal adult group (p<0.05, p<0.0001). Plasma level of zinc was not significantly different between diabetic and normal adults at baseline. However, plasma zinc level increased significantly in both diabetic patients and normal adults after zinc supplementation. The changes in plasma copper levels following zinc supplementation were not statistically significant in diabetic subjects as well as in normal adults. These results indicated that four weeks of zinc supplementation did not influence Cu status and that it may contribute to improving the zinc status. Therefore, we suggest that Zn supplementation for a short-term period may improve marginal zinc status of diabetic patients without interfering with their copper status (Korean J Community Nutrition 14(2):229~235, 2009)
대구경북지역 초등학생들의 영양소 섭취상태와 가당식품 섭취와의 관련성
김현정(Hyeon Jung Kim),오현미(Hyun Mee Oh),조영지(Young Ji Cho),윤진숙(Jin Sook Yoon) 대한지역사회영양학회 2010 대한지역사회영양학회지 Vol.15 No.5
This study was conducted to investigate the association of nutrients intake with sugar-containing food consumption of elementary school students in Daegu-Kyungpook area. We analyzed the dietary information from 164 elementary school students (82 boys, 82 girls) participated in Dietary Intake Survey of Infants, Children and Adolescents conducted by Korea Food & Drug Administration and Korea Health Industry Development Institute. Information on habitual dietary intake of sugar-containing foods was collected by food frequency questionnaires. Daily nutrients intake of each subject was calculated from 24-hour recall data for two non-consecutive days. As a result of average daily intake of major foods of elementary school students was analyzed from 1 to 50 ranking that show up higher ranking of white milk and white rice but include many kind of sugar-containing food. Dietary intake of energy, carbohydrate, Ca, P, Fe and riboflavin were significantly lower for girls with higher sugar-containing food frequency scores. Significantly negative associations between Index of Nutrition Quality (INQ) and sugar-containing food frequency scores were observed for calcium (r = -0.34) and iron (r = -0.32) among girls. Mean Adequacy Ratio (MAR) was significantly lower for girls with higher sugar-containing food frequency scores (r = -0.26). Our results indicated that nutrition education for elementary school students should focus on the importance of reducing the sugarcontaining food consumption with more attention for girls. (Korean J Community Nutr 15(5): 573~581, 2010)
림프구의 부착과 이동을 조절하는 세포간 부착 분자 ICAM-1의 세포질 영역에 관한 연구
서검석(Geom-Seog Seo),최민규(Minkyu Choi),오현미(Hyun-Mee Oh),이무형(Moo Hyung Lee),이강민(Kang-Min Lee),나용호(Yong-Ho Nah),전창덕(Chang-Duk Jun) 대한해부학회 2005 Anatomy & Cell Biology Vol.38 No.1
ICAM-1의 세포질 영역이 림프구 세포의 부착과 이동을 조절할 수 있는 지를 알아보기 위해, 세포질 영역이 삭제된 여러 형태의 mutant type ICAM-1_GFP를 제작한 후, SDF-1α 케모카인에 의한 T 림프구의 부착과 이동을 연구하였다. 세포질 영역이 없거나, 세포질 영역 중 α-actinin 결합자리가 없는 mutant type ICAM-1_GFP의 경우, actin cytoskeleton과 결합할 수 없어서 wild type과 상당히 다른 세포막 발현형태를 나타내었다. T 림프구의 표면 인테그린이 SDF-1α에 의해 활성화되면, 활성화된 LFA-1과 ICAM-1의 결합에 의해 T 림프구가 ICAM-1 발현세포에 부착하게 되는데, 이 과정에서 ICAM-1의 세포질 영역은 그다지 역할을 하지 않는 것으로 나타났다. 림프구 부착 후, 림프구를 감싸기 위한 막 돌기가 형성되는 것을 볼 수 있는데, 세포질 영역이 없는 mutant type ICAM-1_GFP는 wild type에 비해 막 돌기를 잘 형성하지 못하는 것을 관찰할 수 있었다. 이러한 결과들은 ICAM-1의 세포질 영역이 림프구 세포의 부착과정에서 역할을 하는 것이 아니라, 부착 후 막 돌기가 형성되는 과정에서 역할을 한다는 것을 말해주며, 이 후 내피세포를 통한 림프구 세포의 이동 시에도 ICAM-1의 세포질 영역이 중요할 것으로 생각된다. Intercellular adhesion molecule-1 (ICAM-1) has been shown to enhance leukocyte adhesion, thereby inducing migration through blood endothelial cells. However, the molecular event during the process of adhesion is largely unknown. To examine the role of ICAM-1 cytoplasmic domain in SDF-1 α-induced T lymphocyte migration and adhesion, mutant human ICAM-1 molecules were expressed in COS-7 cell line. COS-7 cells expressing ICAM- 1_GFP mutant without α-actinin revealed no association with the actin cytoskeleton, while wild-type ICAM-1 showed clear association with the actin, as observed by confocal microscopy, suggesting that actinin binding motif in the cytoplasmic domain of ICAM-1 is important for the proper localization of ICAM-1 on the cell membrane. However, based on adhesion assay, we found that the cytoplasmic domain of ICAM-1 is not essential for the binding of lymphocytes which were activated by SDF-1α. On the other hand, ICAM-1-mediated receptor-ligand clustering event was significantly inhibited in the cells expressing ICAM-1 mutants without α-actinin or whole cytoplasmic domain. Taken together, these results suggest that ICAM-1 cytoplasmic domain is not essential for the adhesion but important for the ligand-receptor-mediated membrane projection of endothelial cells before trans-endothelial migration of lymphocytes.
김미혜(Kim, Mi-Hye),김한나(Kim, Han Na),신윤미(Shin, Yoon-Mee),오현미(Oh, Hyun-Mi),이정섭(Lee, Jeong-Seop) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.12
본 연구는 S시에 거주하는 근무경력 3년 이상의 지역사회 정신보건간호사 9명의 참여로 2014년 11월 7일부터 2014 년 12월 21일까지 정신보건간호사들의 폭력경험의 의미 및 본질을 현상학적 접근방법으로 밝히고자 시도된 질적 연구이다. 연구결과 정신보건간호사의 폭력 경험은 ‘폭풍우를 만난 쪽배’, ‘망망대해’, ‘푯대를 잃어가는 쪽배’, ‘방향키를 다시 잡은 선장’의 4개 범주와 11개의 주제모음 등으로 나타난 것을 볼 때, 정신보건간호사들이 경험하는 환자로부터의 폭력은 전문가 의 안전을 위협할 뿐 아니라 정신보건 간호사의 정체성에도 영향을 미치는 것으로 볼 수 있다. 이는 환자에 대한 양질의 서비스 제공을 위협할 수 있으므로 심각한 현실 문제로 받아들여야 할 것이다. 또한 폭력 발생 예방에 대한 대책마련과 함께 폭력 피해 당사자인 간호사에 대한 간호조직의 지지프로그램 개발이 무엇보다 선행되어 정신보건간호사들의 안전과 질 높 은 간호업무 수행을 위해 실제적인 대책을 마련해야 할 것으로 사료되어 진다. This study is a qualitative study to disclose the meaning and reality of violence experiences of the mental health nurses by the phenomenological approach. This study is done with the participation of 9 community mental health nurses who have work experiences more than 3 years in the city of S, from Nov 7, 2014 till Dec 21, 2014. The result of the study revealed that the violence experiences of this study participants may be categorized into 4 categories, 'a small boat running into a storm', 'open sea', 'a small boat lost of the sign post', 'a captain controlling the rudder' and may be identified with 11 theme cluster and 32 theme.Therefore violence from patients who have experienced mental health nurse could be found to affect even the identity of the mental health nurse as well as threaten safety of professionals. This may threaten the quality of service provided to the patient, so we have to accept reality as a serious problem. Also it has been preceded by what the support program development of the nursing organization for the nurse who is violence victims with preparing for violence Prevention. As the result we suggest that you prepare a practical measures for the safety and quality nursing services performed by mental health nurses.
노년기 고혈압 관리 대상자의 체질량지수, 허리둘레에 의한 비만정도와 영양소 섭취 상태 비교 연구
서경희(Kyung Hee Seo),이혜진(Hye Jin Lee),임부돌(Bu Dol Lim),최윤정(Yun Jung Choi),오현미(Hyun Mee Oh),윤진숙(Jin Sook Yoon) 대한지역사회영양학회 2009 대한지역사회영양학회지 Vol.14 No.6
Hypertension and obesity are important modifiable risk factors for cardiovascular disease, the leading cause of death in Korea. Therefore, we assessed the association between dietary pattern and obesity in hypertensive patients to formulate health promotion strategies for the older population. Dietary information was collected from hypertensive patients visiting community health education and information center by using 24 hour recall method. The 2005 DRIs for Koreans was used to evaluate the dietary adequacy. When subjects were categorized by body mass index (BMI) as normal, overweight and obese, no significant difference in energy intake was found among groups. Dietary intakes of folate, and vitamin C in obese hypertensive patients were significantly lower than in normal weight patients (p < 0.05). When we compare the nutritional status by waist circumferences, dietary intakes of zinc, vitamin A, thiamin, vitamin C and folate were significantly lower in the obese group. Vegetable intake was significantly lower in the obese group according to BMI as well as waist circumference. Energy intake from carbohydrate was significantly higher in obese hypertensive patients (p < 0.05). Obese hypertensive patients had a higher risk of nutritional inadequacy compared to normal weight patients. Our results indicated the need for developing interventions that encourage greater consumption of vegetables while cutting down salt intake with wise selection of staple foods, for obese hypertensive patients. (Korean J Community Nutrition 14(6): 831~845, 2009)