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오숙경 ( Sook Kyung Oh ),이명희 ( Myung Hee Lee ),이병희 ( Byung Hee Lee ),서지영 ( Ji Yung Seo ),정민석 ( Min Suk Jung ),박장호 ( Jang Ho Park ),이준상 ( Joon Sang Lee ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6
Cardiac myxoma is the most common primary cardiac tumor, but ventricular myxoma accounts for only 5% of the cases. We report a case of a 62-year-old woman with a left ventricular myxoma emerging from the ventricular side of the mitral valve that led to left ventricular outflow tract obstruction. The patient complained of chest discomfort and dyspnea. A mobile intracardiac mass was seen on echocardiography. The mass was excised and confirmed to be a myxoma by histopathological examination. She was discharged from the hospital without complications and remains asymptomatic. (Korean J Med 2012;83:781-785)
Anti-TNF-α 치료를 받은 강직성 척추염 환자들의 체중과 골밀도 변화
이장원 ( Jang Won Lee ),정민석 ( Min Suk Jung ),김동현 ( Dong Hyun Kim ),이승현 ( Seung Hyun Lee ),오숙경 ( Sook Kyung Oh ),조영선 ( Young Sun Jo ),변상환 ( Sang Hwan Byun ),남경민 ( Kyoung Min Nam ),이충원 ( Choong Won Lee ) 대한내과학회 2013 대한내과학회지 Vol.85 No.5
Background/Aims: To determine the changes in body weight and bone mineral density in patients with ankylosing spondylitis (AS) receiving anti-tumor necrosis factor-α (TNF-α) treatment. Methods: Thirty-one patients with AS (25 males and 6 females) who fulfilled the Modified New York Criteria for AS were included in this retrospective study. All patients had active disease that eventually required anti-TNF-α treatment. Each patient received anti-TNF-α treatment (etanercept 25 mg twice weekly or adalimumab 40 mg twice monthly) for more than 2 years. Body weight, disease activity as Bath ankylosing spondylitis disease activity index (BASDAI), C-reactive protein, erythrocyte sedimentation rate (ESR), lumbar bone mineral density (LBMD), and femoral bone mineral density (FBMD) were measured at baseline and at 1 and 2 years after initiating anti-TNF-α treatment. Results: There was a significant increase in mean body weight at 1 year (1.1 ± 3.8 kg) and at 2 years (1.7 ± 4.8 kg) compared with baseline. The gains in mean BMD of the lumbar spine were significant at 1 year (0.4 ± 0.4) and 2 years (0.5 ± 0.7) compared with baseline. Mean BMD of the femur was also increased at 1 year (0.08 ± 0.7) and 2 years (0.1 ± 0.8) compared with baseline, but these differences were not statistically significant. There were significant decreases in BASDAI at 1 year (-3.3 ± 2.8) and at 2 years (-3.6 ± 2.8) compared with baseline. Conclusions: This study showed significant increases in body weight, lumbar BMD, and BASDAI at 1 year and 2 years in patients with ankylosing spondylitis after receiving anti-TNF-α treatment. (Korean J Med 2013;85:489-494)