고주파정맥경화요법을 이용한 대복재정맥 정맥류의 치료 예 -예보-

오병민 ( Byung Min Oh ),박동재 ( Dong Jae Park ),이석종 ( Seok Jong Lee ),나건연 ( Gun Yoen Na ),김도원 ( Do Won Kim ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.12

N/A Background : For the treatment of primary varicose vein of greater saphenous vein(GSV) due to reflux from incompetent saphenofemoral junction(SFJ), several methods such as ligation and stripping, or duplex-guided sclerotherapy have traditionally been introduced. As for sclerotherapy, the recurrence rate has been reported to be very high. In spite of higher success rate, traditional high ligation with stripping of GSV requires several days` admission with general anesthesia and several more days before returning to normal daily life. New modalities, which are less invasive and possibly have lower recurrence to rate with a chance for early ambulation are being proposed. They are such as endovenous radiofrequency(RF) therapy, endovenous laser therapy, etc. Objective - We tried to evaluate the efficacy and safety of endovenous RP therapy as an alternative to high ligation and stripping in case of GSV varicosity in mild to moderate degrees. Methods : Both GSV varicosities and varicosed tributaries are marked by doppler and/or ultrasonic imaging. A catheter connected to RF generator is inserted proximally through the incision of vein wall percutaneously, usually above or below the knee. After confirming position of the SFJ using ultrasound, the catheter is progressed as far as to 1-2㎝ below the SFJ. Then, the generator is activated and the catheter withdrawn slowly for complete heating and occlusion of the target vein. Additional ambulatory phlebectomy or sclerotherapy is optional. We wrap the limbs with self-adhesive short stretch bandage for 2-3 days and encourage the patient to walk regularly and wear compressive stocking later. Results : We performed endoluminal RF treatment on 10 legs of 9 patients(5 males & 4 females). Follow-up intervals varied from 2 to 10 months. Patients were generally satisfied with improvement of symptom. On the clinical evaluation with doppler and duplex examination, there were a few blood flows except only some segments of GSV in 7 patients. Conclusion : Although endoluminal RF therapy may have a somewhat higher recurrence rate than that of traditional high ligation with stripping of GSV, endoluminal RF therapy is expected to have several advantages over traditional surgery, including less invasiveness, no need for admission or general / spinal anesthesia, earlier return to normal daily life, and finally easy performance, especially for the dermatologist. (Korean J Dermatol 2002:40(12) : 1498∼1504)

유산균 발효 식혜의 품질 특성 및 기능성 평가

오병민(Byung-min Oh),전현일(Hyun-Il Jun),오현화(HyeonHwa Oh),조승화(Seung-Wha Jo),정도연(Do-Youn Jeong),김영수(Young-Soo Kim),송근섭(Geun-Seoup Song) 한국식품영양과학회 2020 한국식품영양과학회지 Vol.49 No.8

본 연구에서는 국내산 쌀의 활용도를 높이고자 국내산 막걸리에서 분리한 유산균을 활용하여 유산균 발효 식혜(SFLAB)를 제조했으며, 그에 따른 이화학적 특성 및 기능성을 평가하였다. 쌀막걸리에서 분리한 5종의 유산균 중에서 식혜를 기질로 하는 젖산 발효에 적합한 유산균으로 총산도 함량이 가장 높은 Lactobacillus plantarum LM001을 선정하여 이를 이용해 제조한 SFLAB의 이화학적 특성 및 기능성의 결과는 다음과 같다. SFLAB의 수용성 고형분, 환원당, pH, 총산도, 생균수 및 TPC는 각각 9.38~11.30°Brix, 68.39~89.11 ㎎/mL, 2.80~4.54, 0.01~0.52%, 6.33~8.43 ㏒ CFU/mL 및 0.64~0.68 ㎎/mL였으며, 젖산 발효가 진행됨에 따라 수용성 고형분, 환원당, pH 및 TPC는 감소하였으나 총산도와 생균수는 증가하였다. SFLAB의 유기산은 oxalic acid, lactic acid, pyroglutamic acid 3종이 검출되었고 lactic acid가 총 유기산(185.23~988.31 ㎎%)의 78.10~97.30%를 함유하여 주요 유기산으로 나타났으며, 유리당은 총 유리당(6,719.33~9,685.52 ㎎%)의 87.80~96.79%를 함유한 maltose가 주요 유리당으로 나타났다. 항산화 활성(DPPH 라디칼 소거 활성, ABTS 라디칼 소거 활성 및 환원력)은 각각 58.65~66.90%, 46.09~39.57% 및 0.39~0.46으로 젖산 발효가 진행됨에 따라 각각 1.4배, 1.2배 및 1.2배가 감소하였으나, lipase 저해 활성은 0.71~60.61%로 85배 증가하였다. 항균 활성은 Bacillus cereus KACC 10097, KACC 13064 및 KACC 13066에서만 활성을 확인하였다. 결과적으로 SFLAB의 항산화 활성은 감소했을지라도 항비만과 항균 활성이 증가하였기에 새로운 형태의 기능성 강화식품으로서의 가능성이 있다고 판단된다. This study was carried out to investigate the effects of lactic acid bacteria on the quality and functional characteristics of Sikhye. Of the five lactic acid bacteria strains isolated from Makgeolli, lactic acid bacterium Lactobacillus plantarum LM001, showing the highest total acidity, was selected for the production of Sikhye fermented by lactic acid bacteria (SFLAB). Soluble solids, reducing sugar, pH, total acidity, viable cell count, and total phenolic content of SFLAB were 9.38∼11.30°Brix, 68.39∼89.11 ㎎/mL, 2.80∼4.54, 0.01∼0.52%, 6.33∼8.43 ㏒ CFU/mL, and 0.64∼0.68 ㎎/mL, respectively. As lactic acid fermentation progressed, soluble solids, reducing sugar, pH, and total phenolic content increased, whereas total acidity and viable cell count decreased. The major organic acid and free sugar contents of SFLAB were lactic acid (144.66∼961.63 ㎎%) and maltose (8,504.01∼6,503.92 ㎎%), respectively. Lipase inhibitory and antimicrobial activities for Bacillus cereus of SFLAB increased as lactic acid fermentation progressed. These results suggest that SFLAB may be useful as a potential functional food for enhancing health.

민감성 피부에서 각종 젖산 자상 검사의 결과 비교

오병민 ( Byung Min Oh ),김도원 ( Do Won Kim ),이석종 ( Seok Jong Lee ),나건연 ( Gun Yoen Na ),정상립 ( Sang Lip Jung ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.5

N/A Background : There is no clear dermatologic definition to describe sensitive skin which usually includes subjective and psychological meanings. Some individuals exhibit exaggerated response, especially on the face, ranging from itching to intense adverse reaction like erythema, wheal, and eczema in comparison to normal ones when exposed to external irritants, allergens, environmental changes or internal stimulants. Objective : To diagnose sensitive skin, lactic acid sting test is well known to represent a person who has subjective symptoms like itching, burning, prickling and stinging. We tried to compare several lactic acid sting tests to search for sensitive skin conveniently and rationally. Methods : A total of 50 panelists (25 people of sensitive group and 25 people of control group, respectively) were selected by the method of self-assessment questionnaires related to sensitive skin. The panelists were tested on face, by conditioning 3 variances (5% or 10% Lactic acid, Hydration, Hilltop chamber), in 2 week intervals, 8 times totally. Results : When lactic acid sting tests were performed using Hilltop chamber, there were more positive responders in sensitive group(p<0.05). There was statistically a significant difference between the 2 groups in the comparison of mean values of lactic acid sting scores (p<O.05). Sensitive group showed higher sting scores and exhibited much more difference with time (p<0.05). Conclusion : Our experiment showed that occlusive technique using Hilltop chamber was an inspiring and useful method of several lactic acid sting tests to find out sensitive skin. (Korean J Dermatol 2003;41(5) 569~577)

유산균 발효 식혜 첨가 떡볶이 떡의 품질 특성 및 유통기한 설정

전현일(Hyun-Il Jun),오병민(Byung-min Oh),오현화(HyeonHwa Oh),정도연(Do-Youn Jeong),김영수(Young-Soo Kim),송근섭(Geun-Seoup Song) 한국식품영양과학회 2020 한국식품영양과학회지 Vol.49 No.8

본 연구에서는 국내산 쌀의 활용도를 높이고자 항비만과 항산화 활성이 있는 유산균 발효 식혜(SFLAB)를 사용하여 유산균 발효 식혜 첨가 떡볶이 떡(TTSFLAB)을 제조하였으며, SFLAB 첨가량에 따른 TTSFLAB의 품질 특성 및 유통기한을 살펴보았다. TTSFLAB는 SFLAB 첨가량이 증가할수록 수용성 고형분, 환원당, 총산도, TPC, a<SUP>*</SUP>, b<SUP>*</SUP> 및 항산화 활성은 증가하였으나 pH와 L<SUP>*</SUP>은 감소하였다. SFLAB 첨가량별로 제조한 TTSFLAB를 저장온도(10℃, 20℃, 30℃)와 저장기간별로 분석한 pH와 총산도는 저장기간이 길어질수록 pH는 감소하고 총산도는 증가하였다. 한편 총균, E. coli 및 Bacillus cereus는 저장기간과 저장온도가 증가할수록 각 미생물 수가 증가하였는데 SFLAB의 첨가량이 증가할수록 미생물의 생장속도를 지연시키는 것으로 나타났다. 결과적으로 떡볶이 떡을 살균 처리하지 않고 SFLAB의 첨가만으로도 유통기한을 2~4일 증가시킨 것은 매우 긍정적인 효과라고 판단된다. This study was carried out to investigate the effects of Sikhye fermented by lactic acid bacteria (SFLAB) on the quality characteristics and shelf-life of Tteokbokki tteok. Soluble solids, reducing sugar, pH, total acidity, and total phenolic content (TPC) in 0% Tteokbokki tteok added with Sikhye fermented by lactic acid bacteria (TTSFLA) were 0.60°Brix, 4.23 ㎎/g, 5.52, 0.03%, and 0.04 ㎎/g, respectively. As addition of TTSFLAB increased, soluble solids, reducing sugar, total acidity, and total phenolic content increased. Among the five TTSFLABs, 100% TTSFLAB showed the highest antioxidant activity as well as TPC. The antioxidant activities of 100% TTSFLAB were 2.94, 4.22, 3.29, and 6.17 times higher than those of 0% TTSFLAB in terms of DPPH radical assay, ABTS radical assay, reducing power, and ORAC, respectively. The microbiological properties of TTSFLAB based on total viable count, E. coli, and Bacillus cereus were investigated at different fermentation temperatures and periods, to determine shelf-life. As fermentation temperatures and periods increased, these parameters also increased remarkably. Total viable count showing the shortest shelf-life (9∼13 days at 10℃, 5∼7 days at 20℃, and 3∼5 days at 30℃, respectively) was selected as an indication parameter for shelf-life prediction of TTSFLAB. These results suggest that SFLAB may be useful as a potential functional food ingredient for enhancing health and shelf-life.

신경섬유종증에 동반된 신경절신경종 2예

이원채 ( Won Chae Lee ),오병민 ( Byung Min Oh ),장윤환 ( Yun Hwan Jang ),이석종 ( Seok Jong Lee ),정상립 ( Sang Lip Chung ),이수경 ( Soo Kyung Lee ),배한익 ( Han Ik Bae ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.4

Ganglioneuroma is the benign tumor exclusively composed of fully differentiated mature ganglion cell, Schwann cells and fibrous tissue. It develops most commonly in the posterior mediastinum and retroperitoneum but cutaneous involvement is exceedingly rare. Cutaneous tumor showing ganglion cells includes the following three entities: 1) primary ganglioneuroma, 2) well differentiated cutaneous metastasis from neuroblastoma, and 3) ganglioneuroma associated with von Recklinghausen`s neurofibromatosis. Among them, the third has been considered as a neurofibroma with entrapment of ganglion cell. We described 2 cases of ganglioneuroma associated with von Recklinghausen neurofibromatosis and reviewed the histopathological and immunohistochemical findings. (Korean J Dermatol 2003;41(4) : 470-473)

피부로 전이된 자궁경부 유래의 신경내분비 세포암

박동재 ( Dong Jae Park ),오병민 ( Byung Min Oh ),이석종 ( Seok Jong Lee ),나건연 ( Gun Yeon Na ),김도원 ( Do Won Kim ),정상립 ( Sang Lip Chung ),곽은경 ( Eun Kyung Kwak ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.4

Neuroendocrine carcinoma is known to have features of neuroendocrine and epithelial differentiation through immunochemical and biochemical investigation and Merkel cell carcinoma is a rare primary malignancy of the skin belonging to the broad spectrum of tumors of the neuroendocrine system. Small cell carcinoma of uterine cervix, also a kind of neuroenodcrine carcinoma, is rarely reported and it is much more exceptional in the world that cervical carcinoma metastases to distant skin. Further more this may be the first case of a uterine neuroendocrine carcinoma metastasizing to the skin in Korean medical literature. We report a case of 74-year-old woman who presented with a somewhat fixed subcutaneous nodule measuring 2.5 ㎝ × 0.8 ㎝ on the left side of forehead. A biopsy of the nodule revealed a poorly differentiated carcinoma under the muscle without involvement of upper structures and it showed neuroendocrine differentiation by immunohistologic studies. Before appearing as cutaneous manifestation 2 months ago, she had showed a history of abnormal vaginal bleeding and diagnosed as a cervical neuroendocrine carcinoma, especially small cell carcinoma histologically. (Korean J Dermatol 2003;41(4) : 484-488)

Polymorphisms in the MC1R (Melanocortin-1 Receptor), Arg163Gln and Va192Met, are Involved in Susceptibility to Vitiligo

나건연 ( Gun Yoen Na ),박춘식 ( Choon Sik Park ),오병민 ( Byung Min Oh ),박지영 ( Jee Young Park ),이국형 ( Kuk Hyeong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2002 초록집 Vol.40 No.20

성인에서 발생한 단발성 근섬유종 1예

이정주,오병민,이석종,김도원,정상립,금윤섭 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.8

Solitary myofibroma is a recently described, benign neoplasm of superfical soft tissue, which represents the adult counterpart of infantile myofibromatosis. In Korean literature, only one case has been reported, and we report an additional case of solitary myofibroma in a 57-year-old man. He presented with 2-month history of asymptomatic slightly elevated pale-skin-colored nodule occurring on the right side of philtrum. A histopathologic examination revealed diffuse proliferation of fibroblasts and spindle cells with a whorled arrangement and grouped fascicles. The tumor cells were positively stained for vimentin and smooth muscle actin.

일란성 쌍생아에서 발생한 카포시 수두양 발진

이석종,정상립,오병민,김도원,류효섭 대한피부과학회 2002 대한피부과학회지 Vol.40 No.6

Kaposi's varriceiliform eruption is characteristic syndrome of disseminated vesiculopustules superimposed on variable pre-existing dertnatoses. Among these, atopic dermatitis is most common disease. We report two casts of Kaposi's varicelliform eruption associated with atopic dermatitis in a pair of identical twins. Diagnosis was made by the history, clinical feature, histologic examination and serologic test. These patients' condition was much improved by the treatment with antiviral agent and antibiotics.

소아에서 발생한 양측성 대상포진 1 예

이정주,황성주,김도원,정상립,이석종,오병민 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.11

Noncontiguous bilateral herpes zoster is very rare, especially in a child. Herpes zoster duplex bilateralis means that both halves of the body are involved with the disease. A 4 - year-old female, previously healthy, was presented with painful grouped papulovesicles on an erythematous base on both sides of the trunk (left T5 dermatome & right T7,8 dermatomes). Tzanck smear showed multinucleated giant cells and the histopathologic findings were consistent with herpes viral infection. She was treated with oral acyclovir for 7 days without any significant complication.