정신분열병의 시각자극 사건유발전위 P300에 대한 연구

오동훈,남정현,안동현,김석현,최준호,Oh, Dong-Hoon,Nam, Jung-Hyun,Ahn, Dong-Hyun,Kim, Seok-Hyun,Choi, Joon-Ho 대한생물정신의학회 2004 생물정신의학 Vol.11 No.1

Objective:Event-related potentials(ERPs) are electrical changes recorded at the surface of the scalp in response to stimulus presentation, and their latency and amplitude change according to cognitive processes. Through past studies of the auditory ERP in schizophrenia, the P300 has been reported to be statistically smaller and delayed in schizophrenia than comparison groups. However, studies of the visual ERP have not been systematically examined. The present study was designed to investigate the visual P300 in patients with schizophrenia and normal controls and to compare the pattern of P300 between them. Methods:The subjects were composed of patients(N=22) with schizophrenia by DSM-IV and normal controls(N=22). The visual ERPs were measured by the visual continuous performance test. P300 amplitude and latency measured on 5 scalp electrodes(Fz, Cz, Pz, $T_7$, $T_8$) were compared between patients and controls. Results:The P300 latencies measured on Fz, Cz, Pz, and $T_7$ electrodes were significantly longer in patients than controls(p<0.05). The P300 amplitudes in patients were smaller than controls. However, the difference between them was not statistically significant. Conclusion:Analysis of the visual ERPs showed that the P300 latency is significantly delayed and the P300 amplitude is slightly smaller in patients than controls. These results are similar to established studies of the auditory P300 in schizophrenia.

단일벽 탄소나노튜브 필름의 전기적 및 광학적 특성

오동훈,강영진,정혁,송혜진,조유석,김도진,Oh, Dong-Hoon,Kang, Young-Jin,Jung, Hyuck,Song, Hye-Jin,Cho, You-Suk,Kim, Do-Jin 한국재료학회 2009 한국재료학회지 Vol.19 No.9

Thin films of single-wall carbon nanotubes (SWNT) with various thicknesses were fabricated, and their optical and electrical properties were investigated. The SWNTs of various thicknesses were directly coated in the arc-discharge chamber during the synthesis and then thermally and chemically purified. The crystalline quality of the SWNTs was improved by the purification processes as determined by Raman spectroscopy measurements. The resistance of the film is the lowest for the chemically purified SWNTs. The resistance vs. thickness measurements reveal the percolation thickness of the SWNT film to be $\sim$50 nm. Optical absorption coefficient due to Beer-Lambert is estimated to be $7.1{\times}10^{-2}nm^{-1}$. The film thickness for 80% transparency is about 32 nm, and the sheet resistance is 242$\Omega$/sq. The authors also confirmed the relation between electrical conductance and optical conductance with very good reliability by measuring the resistance and transparency measurements.

열충격 단백질의 신경정신의학적 의의와 중요성

오동훈,양병환,최준호,Oh, Dong-Hoon,Yang, Byung-Hwan,Choi, Joonho 대한생물정신의학회 2007 생물정신의학 Vol.14 No.4

Recent researches have shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins(HSPs), also called 'molecular chaperones'. HSPs as molecular chaperones are the primary cellular defense mechanism against damage to the proteome, initiating refolding of denatured proteins and regulating degradation after severe protein damage. HSPs also modulate multiple events within apoptotic pathways to help sustain cell survival following damaging stimuli. HSPs are induced by almost every type of stresses including physical and psychological stresses. Our nervous system in the brain are more vulnerable to stress and damage than any other tissues due to HSPs insufficiency. The normal function of HSPs is a key factor for endogenous stress adaptation of neural tissues. HSPs play an important role in the process of neurodevelopment, neurodegeneration, and neuroendocrine regulation. The altered function of HSPs would be associated with the development of several neuropsychiatric disorders. Therefore, an understanding of HSPs activities could help to improve autoprotective mechanism of our neural system. This paper will review the literature related to the significance of HSPs in neuropsychiatric field.

부산북항 재개발에 따른 유동장 및 해수교환 변화 모의

오동훈,이중우,금동호,전성환,김강민,Oh, Dong-Hoon,Lee, Joong-Woo,Keum, Dong-Ho,Jun, Sung-Hwan,Kim, Kang-Min 한국항해항만학회 2006 한국항해항만학회지 Vol.30 No.10

부산항(북항) 재개발사업은 노후화된 북항 일반부두를 해양관광의 중심지역 그리고 부산시민을 위한 친수공간으로 개발하기 위해 그동안 많은 연구와 노력이 진행되어 왔으며, 현재 구체적인 방안이 모색되는 실행단계로 진입하였다. 한편, 재개발로 인한 유동장 및 해수교환의 변화는 환경적인 측면에서 중요한 검토사항 중 하나이다. 본 연구에서는 북항 재개발에 따른 일반적인 자료를 수집 분석하고, 이를 바탕으로 하여 재개발에 따른 유동장의 변화와 만 내 해수교환을 수치실험으로 검토하였다. 실험결과, 조류속 변화는 북항 및 내항에서 감소가 나타나고 주수로상에서 증가가 나타나고 있다. 해수교환 변화는 15일이 지난 준 정상상태에서 재개발 전후 공히 약 77% 내외에 달하는 것으로 나타났다. In connection with redevelopment of Busan North Port, there has been lots of studies and efforts for the development of superannuated North general piers into a center of marine tourism and waterfront for the citizens of Busan. Recently it has moved to the stage of execution, after several trials to find concrete solutions. On the other hand, the change of flow field and tidal exchange cuased by redevelopment is one of the important investigation subjects. This study deals with the change of flow field and water exchange after redevelopment using numerical simulation technique, based on the general data which were collected and analyzed. As a result of simulation, the speed of tidal currents are tended to decrease near the North and inner-port and increase at the main waterway. Furthermore, the tidal exchange had a tendency to be small both before and after redevelopment by about 77% in a quasi steady state, which is about 15 days after.

안구운동 민감 소실 및 재처리 요법(Eye Movement Desensitization and Reprocessing) 치료 후 국소 뇌 혈류 변화:두 증례의 SPECT 연구

오동훈,최준호,Oh, Dong-Hoon,Choi, Joonho 대한생물정신의학회 2004 생물정신의학 Vol.11 No.2

Over the last decade, EMDR(Eye Movement Desensitization and Reprocessing) has emerged as a promising new treatment for trauma and other anxiety-based disorders. However, neurobiological mechanism of EMDR has not been well understood. Authors report SPECT findings of two patients of PTSD before and after EMDR. Brain 99mTc-ECD-SPECT was performed before and after EMDR treatment. To evaluate the significance of changes in the regional cerebral perfusion, t-test was conducted on the resulting images using SPM99. In addition, clinical scales(CAPS, CGI, STAI) were employed to asses the changes in the clinical symptoms of the patients. After EMDR treatment, each showed significant improvement in clinical symptoms. The cerebral perfusion increased in bilateral dorsolateral prefrontal cortex, and decreased in the temporal association cortex. The differences in the cerebral perfusion between patients after treatment and normal controls decreased. These changes appeared mainly in the limbic area the and the prefrontal cortex. These results suggest that EMDR may show the therapeutic effect through 1) improvement in the emotional control by increased activity in the prefrontal cortex, 2) inhibited hyperstimuli on amygdala by deactivation of the association cortex, 3) inhibition on past trauma related memory, and 4) keeping the functional balance between the limbic area and the prefrontal cortex. This case report needs further replication from studies with larger sample.

유기 광기전 소자의 전기적 특성에 미치는 산소 플라즈마 처리의 영향

오동훈(Dong-Hoon Oh),이영상(Young-Sang Lee),박희두(Hee-Doo Park),신종열(Jong-Yeol Shin),김태완(Tae-wan Kim),홍진웅(Jin-Woong Hong) 대한전기학회 2011 대한전기학회 학술대회 논문집 Vol.2011 No.7

유기 광기전 소자의 전기적 특성에 미치는 산소 플라즈마 처리의 영향

오동훈(Dong-Hoon Oh),이영상(Young-Sang Lee),박희두(Hee-Doo Park),신종열(Jong-Yeol Shin),김태완(Tae-Wan Kim),홍진웅(Jin-Woong Hong) 대한전기학회 2011 전기학회논문지 Vol.60 No.12

An indium-tin-oxide (ITO) is normally used as a substrate in organic photovoltaic cells. We examined the effects of an oxygen (O₂) plasma treatment on the electrical properties of an organic photovoltaic cell. Experiments with four-point probe method and atomic force microscope revealed the lowest surface resistance of 17.64 Ω/sq and the lowest average surface roughness of 1.39 ㎚ at the plasma treatment power of 250 W. A device structure of ITO/CuPc/C60/BCP/Cs₂CO₃/Al was fabricated by thermal evaporation with and without the plasma treated ITO substrate. It was found that the power conversion efficiency of the cell with the plasma treated ITO is 65 % higher than the one without the plasma treated ITO.

가족력 유무에 따른 알코올중독환자의 임상적 특성

오동훈(Dong-Hoon Oh),김길숙(Gil-Sook Kim),오동열(Dong-Yul Oh) 한국중독정신의학회 1997 중독정신의학 Vol.1 No.1

Object:We attempted to clarify the clinical characteristics of alcoholics according to family history of alcoholism. Method:We examined 51 men alcoholics who had been admitted to alcoholic open ward in Seoul National Mental Hospital from June 1st 1996 to June 30th 1996 according to their family history of alcoholism. We perfomed semi-structured interview for demographic data, drinking history, and social consequences. Self-report questionnaires for severity of alcoholism(Alcoholism Screening Test of Seoul National Mental Hospital;NAST), depression(Korean Version Beck Depression Inventory;K-BDI) and anxiety(State-Trait Axiety Inventory;STAI-trait and state) were given to all subjects at least 2 weeks later after admission. Result: 1) The number of familial alcoholics were 22 and those of non familial alcoholics were 29. 2) Mean age on admission(p<0.05) and age when first diagnosed as alcoholism(p<0.05) was significantly younger in familial alcoholics than in non-familial alcoholics. 3) Familial alcoholics were scored significantly higher than non-familial alcoholics in Alcoholism Screening Test of Seoul National Mental Hospital(p<0.05), Korean Version Beck Depression Inventory(p<0.05), and State-Trait Anxiety Inventory(p<0.05). Conclusion:Therefore special attention is needed for familial alcoholics due to above clinical characteristics.

일본에서의 물리학 연구의 태동과 성장, 1880~1920

오동훈 ( Dong Hoon Oh ) 한국과학사학회 2003 한국과학사학회지 Vol.25 No.1

u-Eco City 비즈니스 전략 모색

오동훈(Oh Dong-Hoon),지성현(Sunghyun Ji),박선영(Sun-Young Park) 한국도시행정학회 2010 도시 행정 학보 Vol.23 No.4

Since u-Eco City as a inclusive concept of combined object of u-City and Eco-City is premised on both ubiquitous technology and low-carbon green growth which enables the integration of time and space by using information technology, it has a meaning of fusion of green technology. In order to setup the continuos development plan of u-Eco City as a new growth engine of our nation, business strategies for commercializing upgraded city-related goods have definitely been needed. Therefore, the purposes of the study are as follows; first, it analyzes the inside ability of u-Eco City good, second, it tries to detract core value for making business strategy optimized to u-Eco City, third, it setup business model for u-Eco City good, and finally it finds key success factor for successful business operation. From the above procedure, the study showed the three kinds of research outcomes. Firstly this study assumed four core values such as velocity, optimality, profitability, and infrastructure system. Secondly it proposed business model for u-Eco City. The important components of the business model comprised of core value, value proposition, and acting model. Thirdly it drew the 13 key success factors of u-Eco City business strategy with the business model. The results of the paper provide us with the essential and basic frame for enhancing value-added of u-Eco City good which contributes to our nation’s brand as a new growth engine of future economic environment in Korea.