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여장옥(Jang Ok Yeo),이창희(Chang Hee Lee),이선욱(Seon Uk Lee),이상혁(Sang Hyuk Lee) 대한두경부종양학회 2010 대한두경부 종양학회지 Vol.26 No.1
Non-lymphoid mesenchymal neoplasms of salivary gland origin are rare, accounting for 1.4% of major sal-ivary gland tumors. Of this group 30% were hemangiomas. Hemangiomas are the most common benign tumors in children, but are rare in old ages. 90% of hemangiomas arise in the first three decades of life. Hemangiomas are classified as capillary(including juvenile type), cavernous, or mixed in type. Salivary gland hemangioma is more common in the parotid(90%) and extremely rare in submandibular gland. We present two adult pa-tients, 69 and 60 years of age, who were referred for palpable mass in the parotid area and submandibular area, respectively. After surgical removal of the lesion, histopathologic examination showed characteristic feature of cavernous hemangioma. The rarity of such a lesion in these locations in old ages have prompted this case report.
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최정임,여장옥,진성민,이상혁,Choi, Jeong-Im,Yeo, Jang-Ok,Jin, Sung-Min,Lee, Sang-Hyuk 대한후두음성언어의학회 2011 대한후두음성언어의학회지 Vol.22 No.1
Background and Objectives: Vocal polyps arc one of the most frequent benign laryngeal diseases. They arc usually found at the midpoint of the vocal fold. They are mainly caused by vocal overuse. Vocal polyps arc usually removed surgically. Generally, age-related changes to speech are attributed to change in anatomy and physiology of the speech mechanism. These changes result in increased variability in the acoustic properties of speech with age. Still, not 'all studies of age-related changes in speech have taken differences between the young group and adult group after laryngeal microsurgery into account. The aim of this investigation was to compare improvement of acoustic analysis in young patients and elderly patients with vocal polyps, before and after the laryngeal microsurgery. Materials and Method: One hundred and twenty-eight patients who underwent laryngeal microsurgery for vocal polyps from 2008 through 2011 were reviewed retrospectively. 105 of the 128 patients under age 60 were classified as adult group (AG), and remaining 23 patients as elderly group (EG). The speech of AG and EG were evaluated before and after surgery for identification of differences for age group across measures of fundamental frequency (F0), Jitter, Shimmer and Maximum phonation time (MPT). Results: There were not significant differences between two groups for improvement of F0, Jitter, Shimmer, NHR, and MPT before and after surgery. The findings suggest that elderly group compares quite well with adult group in effectiveness of surgery. However, comparison between elderly group and young group (Age under 40) there was significant difference of improvement in Jitter and Shimmer. Conclusion: In general, the results of the present research showed significant improvement in vocal quality after phonosurgery of vocal polyp in both elderly and adult group. However, comparison of improvement between elderly group and young group, there were significant differences of improvement in jitter and shimmer. Therefore, in treatment planning of elderly group, we should consider age related changes of vocal cord.
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최현진,송윤경,여장옥,허세형,진성민,Choi, Hyun-Jin,Song, Yun-Kyung,Yeo, Jang-Ok,Huh, Se-Hyung,Jin, Sung-Min 대한후두음성언어의학회 2008 대한후두음성언어의학회지 Vol.19 No.2
Background and Objectives: The voice changes can occur in peritonsillar abscess and the labeling of this changes as a "muffled voice". The aim of this study was to investigate the changes in acoustic feature of voice before and after treatment in patients with peritonsillar abscess. Materials and Method: 12 patients with peritonsillar abscess were enrolled in the study. Acoustic analysis on sustained Korean vowels /a/, /i/ and /u/ were performed before and after treatment. Results: In patients with peritonsillar abscess, the first formant frequency (F1) and second formant frequency (F2) of /a/ were decreased. There was tendency of articulation of back-low vowel /a/ as back-high vowel /u/. F1 of /i/ and /u/ were increased, while F2 were decreased. There was tendency of articulation of front-high vowel /i/ as back-low vowel /a/. The third, forth, fifth formant frequency (F3, F4, F5) of /a/, /i/ and /u/ were decreased although statistically not significant. Conclusion: The anatomical and functional changes of oropharynx by peritonsillar abscess can cause changes in resonance and speech quality. We suggest that these changes could be the cause of 'muffled voice' in patients of peritonsillar abscess.
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이남훈,최현진,여장옥,이상혁 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.12
Even though pleomorphic adenoma is the most common benign tumor of the major salivary gland, such as the parotid gland, it is relatively rare in the minor salivary gland since it accounts for only 10% of all reported pleomorphic adenoma. The minor salivary gland spreads throughout the oral cavity from nasopharynx, oropharynx, to larynx, and pleomorphic adenoma can be possibly found in every one of them. However, pleomorphic adenoma of the larynx is very rare. We experienced a case of 59 year old woman who presented 3 months history of voice change, swallowing difficulty. She had huge pleomorphic adenoma originated from arytenoid area of larynx. We resected the mass by suprahyoid approach and obtained good postoperative results. We reporte this case with a review of literature. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:1147-50)
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갑상선 유두상암에서 림프절 전이 유무에 따른 Bcl-2, Bax 및 p27의 발현양상
이성진,진성민,이상혁,여장옥,이선욱,손진희,채승완,김동훈 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.3
Background and ObjectivesZZThe aim of this study was to investigate the relationship between the expression of Bcl-2, Bax, p27 and lymph node metastasis (LNM) in papillary thyroid cancer (PTC). Subjects and MethodZZThe thyroid tissue samples were obtained randomly from the department of pathology at Kangbuk Samsung Hospital. The specimens were from 72 patients, comprising 25 patients with thyroid nodular hyperplasia (TNH), 23 PTC without LNM, and 24PTC with LNM between January 2006 and May 2008. Immunohistochemical staining for Bcl-2, Bax, and p27 was performed, and quantified blindly by three pathologists who had no clinical information of the patients. Immunohistochemical expression was scored as high (>25% of cells stained) or low (0-25%). ResultsZZExpression of Bcl-2 was scored as high for 1 (4%) TNH, 3 (13%) PTC without LNM and 4 (17%) PTC with LNM cases. Expression of Bax was scored as high for 0 (0%)TNH, 9 (39%) PTC without LNH and 16 (67%) PTC with LNM cases. Expression of p27 was scored as high for 13 (52%) TNH, 12 (52%) PTC without LNM and 13 (54%) PTC with LNM cases. Expression of Bax in the PTC with LNM group was scored higher than TNH (p<.01) and PTC without LNM (p<.05). There was no statistically difference in the immunoreactivity for Bcl-2 and p27 among the three groups. However, some positive expressions of p27were noted at the cytoplasm of the PTC. ConclusionZZOur results suggest that immunohistochemical analysis of Bax may be helpful in the diagnosis of PTC and in the evaluation of lymph node metastatic potential in PTC. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:153-8
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