MPP+로 유도된 신경 독성에 대한 녹각의 보호 효과

여수정 경락경혈학회 2020 Korean Journal of Acupuncture Vol.37 No.2

Objectives : Parkinson’s disease, a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra. There is no clear treatment or remedy for Parkinson’s disease; therefore, the development of novel therapies related to anti-inflammatory and antioxidant effects is required. This study was performed to evaluate the neuroprotective effect of water extracts from Cervi Cornu (CC) in dopaminergic cells. Methods : We studied effects of CC on apoptosis, cell death and inflammation in SH‐SY5Y neuroblastoma cells treated by methylpyridinium ion (MPP+). SH-SY5Y cell line was treated with CC for 24 hours and then 500 μM MPP+ for 18 hours. Results : Cervi Cornu treatment inhibited the decrease in tyrosine hydroxylase (TH) expression and decreased the activation of inflammatory factors mitochondrial cytochrome C oxidase (COX2) and inducible NO synthase (iNOS) against MPP+ neurotoxicity. Apoptosis factors BCL2 associated X, apoptosis regulator (BAX) levels were decreased and B-Cell CLL/Lymphoma 2 (BCL2) levels were increased. Conclusions : These results suggest that CC treatment had neuroprotective effects in the SH‐SY5Y neuroblastoma cells against toxicity induced by MPP+. The results suggest new possibilities of CC for the treatment of Parkinson’s disease. .

경혈 위치교육 평가지원시스템의 개발계획 수립과 제작

여수정,남동현 경락경혈학회 2019 Korean Journal of Acupuncture Vol.36 No.1

Objectives : Teaching the standardized acupuncture point locations and improving the accuracy of acupoint locations through objective evaluation is a very important part of Korean medicine education. The aim of this study is to develop a dummy system for evaluation and support of teaching acupoint location in meridian and acupoints classes and to introduce the developed system. Methods : We established a protocol for the development of the system. The protocol included definition of usage purpose, definition of its essential performance, and set of scope. The system compares the amount of light at the target acupoint with the amount of light at the other sites to determine whether the target acupoint is properly specificated. Results : A prototype of the system was built according to the protocol and consists of light emitter, dummy, control/operation, input part and output part. The light emitter projects laser beam passing through the skin of the dummy. Light sensors were attached inside the acupoints of the dummy. Three types of light sensors were selected depending on the location of the acupoints. The arithmetic, input, and output parts were constructed using Arduino and Raspberry pi boards. The developed system was applied in class. Conclusions : It is thought that the dummy system for evaluation and support of teaching acupoint location can be used as a training model in order to help teach standardized acupoint locations and objective evaluation.

등척성 체간 운동이 젊은 성인의 근지구력과 균형능력에 미치는 영향

여수정,안창식 한국신경근육물리치료학회(구 한국신경근육재활학회) 2021 한국신경근육재활학회지 Vol.11 No.1

This study aims to identify the effects of an isometric trunk exercise program on muscle endurance and balance ability in young adults. Fourteen young adults volunteered to participate in this study. Isometric muscle endurance tests (trunk curl in supine, hyperextension of trunk in prone, and arm-supporting side bridge) and one-leg standing test were used to measure muscle endurance and balance of subjects. Isometric trunk exercises were performed for 30 minutes, twice per week for 6 weeks (a total of 12 sessions), including upper and lower abdominal drawing, abdominal bracing, posterior pelvic tilting, supine bridge exercise, and alternating raising of limbs in quadruped position. After the intervention, significant improvements were found for all items of muscle endurance and balance (p<.05). These findings suggest that an isometric trunk exercise program might be favorably used to enhance muscle endurance if the trunk and balance in young adults. Further studies need to support our findings.

파킨슨병 동물 모델에서 도파민세포의 감소와 관련된 Slc6a4 발현의 증가

여수정 ( Sujung Yeo ) 경락경혈학회 2021 Korean Journal of Acupuncture Vol.38 No.3

Objectives : Parkinson’s disease is a neurodegenerative disease caused by a decrease in the dopaminergic neurons in the substantia nigra. The abnormal expression of solute carrier family 6 member 4 (Slc6a4) has been reported in patients with Parkinson’s disease. Methods : In this study, we used MPTP to examine the changes in the expression of Slc6a4 in the brain of mice with Parkinson’s disease and investigate its effect on dopaminergic neuronal cell death. Results : In the examination of the Slc6a4 expression in the substantia nigra of MPTP-treated mice for 4 weeks. The gene expression was increased compared to the normal group. To investigate the relationship between Slc6a4 and dopaminergic neurons, we performed a study using siRNA of Slc6a4 in the dopaminergic neuronal cell line SH-SY5Y. Using the siRNA of Slc6a4 to evaluate gene expression, it revealed that the tyrosine hydroxylase (TH) expression increases when Slc6a4 decreases. Moreover, this confirms its effects on the dopaminergic neurons. Additionally, through the evaluation of factors related to apoptosis, in particular, it was established that the value of bax/bcl2 decreased and was affected. These results suggest that a decreased Slc6a4 expression induces an increase in TH expression, providing a mechanism of action for dopaminergic neurons regulated by Slc6a4 expression. Conclusions : Slc6a4 is deemed to be involved in the regulation of dopaminergic neurons, suggesting that an increased Slc6a4 expression induced by MPTP may influence a reduction of dopaminergic neurons.

금침과 스테인레스침을 이용한 온침에서의 부위별 온도측정 연구

여수정 ( Su Jung Yeo ) 경락경혈학회 2013 Korean Journal of Acupuncture Vol.30 No.3

Objectives: The warm needling technique is the method combining the effects of acupuncture needle with those of moxibustion. We need to standardize the characteristics of the warm needling technique, in order to get more systematic and objective results in operation and effects and then get more clinical abilities in these fields. Methods: In this study, using labview system on the warm needling technique, we measured and compared partial temperature changes according to the kind of needle. We studied relations of moxa cones of various sizes with the peak combustion temperature. Results and Conclusions: When we measured the warm needling`s partial temperature, temperature measured at 1 and 2 cm below the head, according to the kind of needle, gold needle got the higher result on the peak than SS304 stainless steel needle. In the case of combustion of the moxa cones, cones weighing 0.4 g and 0.8 g, respectively, and the apex ignition method with gold needle showed the higher result than the apex ignition method with stainless steel needle, when we measured the effective stimulus time at 2 cm below the head and the mean temperature during the effective stimulus time. Although more research to standardize the characteristics of the warm needling technique will be needed, we suggest, according to these results, that warm needling of gold needle combined with moxa cone of 0.4 or 0.8 g is effective.

당뇨병 환자 대상 집중관리프로그램이 혈액성상 및 당뇨지식에 미치는 효과

여수정(Su-Jeong Yeo),김복희(Bok-Hee Kim) 대한지역사회영양학회 2018 대한지역사회영양학회지 Vol.23 No.2

온침소재의 열전달특성에 관한 연구

여수정 ( Su Jung Yeo ),정지현 ( Jee Hyun Chung ),김영곤 ( Young Kon Kim ),구성태 ( Sung Tae Koo ),이민규 ( Min Kyu Lee ),임사비나 ( Sabina Lim ) 경락경혈학회 2014 Korean Journal of Acupuncture Vol.31 No.3

Objectives : Warm needling is the method combining the effects of acupuncture and moxibustion. In modern clinics, warm needling is only affected by treatment time or frequency. We need to study the physical characteristics of warm needles currently used in clinics in order to develop more efficient and economical treatments. Methods : We collected various warm needle specimens and analyzed chemical constitutions, measured heat transfer velocity, micro Vicker`s hardness and specific resistance. We studied the relationship between heat transfer velocity and micro Vicker`s hardness as well as that between heat transfer velocity and specific resistance. Results : The heat transfer velocity of the Silver_HL was 3.3 mm/sec, of the Au alloy group was 1.3∼2.6 mm/sec, and Silver_IN, Silver_ZK and SS groups was less than 0.3 mm/sec. We therefore concluded that the needle composed of Ag has the best heat transfer velocity. In the Micro Vicker`s hardness test, Vicker`s hardness of the Au alloy group was 159∼170 Hv, of Silver_HL was 181 Hv, and of the Silver_IN, Silver_ZK, SS group was 450.8∼519 Hv. In the Silver_IN, Silver_ZK and SS groups, hardness was inversely proportial to thermal conductivity. In the specific resistance test, the specific resistance ofSilver_HL was the lowest, that of the Au alloy group was the second lowest, and that of the Silver_IN, Silver_ZK, SS groups were the highest. Conclusions : We concluded that the needle composed of Ag has the best heat transfer velocity, highest electric conductivity and thermal conductivity, therefore the needle composed of Ag is suitable for warm needling.

전남지역 일부 고혈압ㆍ당뇨병 등록ㆍ관리센터 이용자의 일반특성, 자기효능감 및 식생활관리 실태 연구

여수정(Su Jeong Yeo),신인우(In Woo Shin),김복희(Bok Hee Kim) 한국지역사회생활과학회 2015 한국지역사회생활과학회지 Vol.26 No.4

Selenization 온도가 Cu<SUB>2</SUB>ZnSnSe<SUB>4</SUB> 박막의 특성에 미치는 영향

여수정(Soo Jung Yeo),강명길(Myeng Gil Gang),문종하(Jong-Ha Moon),김진혁(Jin Hyeok Kim) 한국태양광발전학회 2015 Current Photovoltaic Research Vol.3 No.3

The kesterite Cu2ZnSnSe4 (CZTSe) thin film solar cells were synthesized by selenization of sputtered Cu/Sn/Zn metallic precursors on Mo coated soda lime glass substrate in Ar atmosphere. Cu/Sn/Zn metallic precursors were deposited by DC magnetron sputtering process with 30 W power at room temperature. As-deposited metallic precursors were placed in a graphite box with Se pellets and selenized using rapid thermal processing furnace at various temperature (480°C~560°C) without using a toxic H2Se gas. Effects of Selenization temperature on the morphological, crystallinity, electrical properties and cell efficiency were investigated by field emission scanning electron microscope (FE-SEM) and X-ray diffraction (XRD), J-V measurement system and solar simulator. Further details about effects of selenization temperature on CZTSe thin films will be discussed.

족삼리 좌우측 자침에 대한 BOLD 반응

여수정 ( Su Jung Yeo ),배성인 ( Seong In Bae ),최일환 ( Il Whan Choe ),장건호 ( Geon Ho Jahng ),임사비나 ( Sabina Lim ) 경락경혈학회 2014 Korean Journal of Acupuncture Vol.31 No.1

Objectives: There has been some controversy about the modulatory effects on brain function during acupuncture on each side of the same acupoint. This study was designed to investigate and compare the blood oxygen level-dependent(BOLD) responses of acupuncture on each side of ST36. Methods: Fourteen healthy subjects were recruited for imaging and received acupuncture or placebo stimulations either on the left or on the right acupoint of ST36 in each scan. For the voxel-wise statistical analysis, one sample T-test and the within-subject analysis of variance(ANOVA) test were performed using SPM8 software. Results: This study showed that acupuncture on each side of ST36 showed different BOLD signal patterns. Higher BOLD responses after acupuncture stimulations at the left ST36 compared to the right were observed mainly in the parahippocampal gyrus(BA 28), dorsolateral prefrontal cortex(DLPFC, BA 44), thalamus, culmen and claustrum. We investigated the different neural responses between rest and activation periods of placebo and acupuncture stimulations on each side of ST36. Acupuncture at the right ST36 elicited activation mainly in the insula, supplementary motor area(SMA) and anterior cingulate cortex(ACC), while acupuncture at the left ST36 elicited activation mainly in the insula, primary somatosensory cortex(SI, BA 2) and DLPFC(BA 44). Conclusions: To our knowledge, this is the first reported functional MRI study directly comparing when needling at the right and at the left side of ST36. This study`s preliminary results proved to be evidence of acupuncture`s different effects when performed on opposite sides of an acupoint.