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NMR-based Fragment Screening of Inhibitors Against p300 CH1 and HIF-1α CTAD Interaction
어유미,심명보,Thuy Nguyen Thi Phuong,Phuong Pham Hoa,안대로,안희철 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.10
NMR spectroscopy of p300 CH1 and HIF-1α CTAD complex was conducted to investigate the conformational status of the complex and to screen the protein–protein interaction inhibitors. The individual p300 CH1 and HIF-1α CTAD were unstructured or partially structured; however, the complex had well-defined folded structure. Since the 1H-15N HSQC spectrum of p300 CH1 or HIF-1α CTAD in the free state was completely different from that in the bound state, it was possible to discriminate whether the protein was in the complex state or not. Fragment compounds were titrated to p300 CH1 and HIF-1α CTAD complex and some showed inhibition of protein–protein interaction based on the analyses of NMR spectra. The result shows that NMR-based screening is possible to discover the fragment chemicals which inhibit the formation of p300 CH1 and HIF-1α CTAD complex.
Baby Giraffe Rope-Pulled Out of Mother Suffering from Dystocia without Proper Restraint Device
용환율,박석현,최명근,정소영,구대창,유종태,유미진,유미현,어경연,여용구,강신근,김헌열 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.1
A 4-year-old female reticulated giraffe (Giraffa camelopardalis reticulata), at Seoul Zoo, Gwacheon, Korea had a male calf with no help of proper restraint devices. The mother giraffe was in a danger of dystocia more than 7 hours in labor after showing the calf’s toe of the foreleg which protruded from her vulva. After tugging with a snare of rope on the metacarpal bone of the calf and pulling it, the other toe emerged. Finally, with two snares around each of metacarpal bones, the calf was completely pulled out by zoo staff. After parturition, the dam was in normal condition for taking care of the calf and her progesterone hormone had also dropped down to a normal pre-pregnancy.