기능성 위장장애

양웅석,Yang, Ung-Suk 한국생명보험의학회 1998 保險醫學會誌 Vol.17 No.-

담석의 내시경적 치료

양웅석,Yang, Ung-Suk 한국생명보험의학회 2000 保險醫學會誌 Vol.19 No.-

소화성 궤양의 진단과 치료

양웅석,Yang, Ung-Suk 한국생명보험의학회 1997 保險醫學會誌 Vol.16 No.-

소화성 궤양에 대한 Famotidine ( Gaster ) 의 치료효과

양웅석(Ung Suk Yang) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1

N/A Famotidinei(Gaster R ) is new H2-receptor blocker with an amide structure at the side chain of thiazole. We have treated 40 cases of endoscopically diagnosed peptic ulcers with famotidine for evaluation of the therapeutic efficiency. Famotidine was administered 20 mg two times daily for 4 weeks and then followed up by endoscopy. Over all improvement of peptic ulcers by endoscopy noted in 77.5% of the patients. 17 out of 22 cases (77.3%) of gastric ulcers and 14 out of 18 cases (77.7%) of duodenal ulcers had been healed up in 4 weeks. Manifestations of peptic ulcer had been improved in 33 out of 40 cases (82.5%) after 4 weeks medication with famotidine. No significant clinical side effects had been noticed with 4 weeks medication. In conclusion, famotidine is effective and safe medicine for the treatment of peptic ulcer diseases.

건강검진을 위해 내원한 한국건강성인의 인체계측지

양웅석(Ung Suk Yang),조중현(Jung Hyun Cho) 대한내과학회 1999 대한내과학회지 Vol.56 No.5

N/A Objectives : It is known that nutritionally depressed patients are approximately 40 to 50% among all of the hospitalized patients and these patients are more vulnerable to complications and delaying in recovery from their diseases than nutritionally normal patients . Exact nutritional assessment and support are one of important measures in treatment of the disease. Both subjective and objective methods of nutritional assessment has been applied usually for exact nutritional assessment and anthropometry has been used for objective assessment of nutritional state. Methods : Author measured of anthropometry such as weight, height, triceps skin folds, midarm muscle circumference, and midarm circumference in order to get standard values of anthropometry in 2926 healthy korean adults from five different districts in Korea. Results: The mean values of the height of Korean were 169±5.9 cm in male, and 156.3±7.9 cm in female and the mean values of 50 percentile of the height were 170 cm in male and 157 cm in female. The mean values of the body weight were 64.2±20.2 kg in male, and 54.5±7.4 kg in female and the mean values of 50 percentile of the body weight were 63 kg in male, and 54 kg in female. The mean values of TSF were 11.7±7.1 mm in male, and 18.5±7.6 mm and the mean values of 50 percentile of the TSF were 10 mm in male, and 18.0 mm in female. The mean values of the MAC were 26.7±3.3 cm in male, and 25.77±.90 cm in female and the mean values of 50 percentile of the MAC were 26.5 cm in male, and 26 cm in female. The mean values of the MAMC were 23.0±3.5 cm in male, and 19.95±3.0 cm in female and the mean values of 50 percentile of the MAMC were 23.0 cm in male, and 19.8 cm in female. Conclusion : The values of this study could be used as the korean standard values having some errors due to different study members, because it was done in large subjects who are living in five different districs in Korea.

상부위장관출혈환자의 (上部胃腸管出血患者) 임상적 (臨床的) 관찰

양웅석(Ung Suk Yang) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1

N/A Clinical observations were given on the 279 cases of upper gastrointestinal hemorrhage admitted to the Pusan University Hospital and Wallace Memorial Baptist Hospital over a period of 5 years from Jan. 1976 to Dec. 1980 and the following result were given. 1) Sex incidence of UGI-hemorrhage revealed male predominance with a ratio of 9:1 and peak age group were 4th and 5th decades. 2) Incidence of hematemesis associated with melena was noted in 78.8%. And melena was in 20.1% 3) Frequency of UGI-hemorrhage prior to admission was third time in 46.7% first time in 36.6%, and second time in 16. 5%. 4) Severity of UGI-hemorrhage was noted massive bleeding in 39.4,moderate bleeding in 34.8% and mild bleeding in 25.6%. G) Endoscopic examinations were performed within 24 hours in 15.7%, 48 hours in 33.6%, and anothers were within 7 days in 73.4%. 6) Causes of UGI-hemorrhage were gastric ulcer(32.6%), esophageal varix(25.1%), duodenal ulcer(12.9%), hemorrhagic gastritis(10.4%), gastric cancer(6.1%), Mallory-Weiss syndrome (3.9%) and marginal ulcer(2.5%). Cause of hemorrhage was not found in 2.5%. 7) UGI-hemorrhage associated with other upper gastrointestinal diseases were noted in 29.1% 8) Operations were done in 55 cases and causative diseases of these cases were gastric ulcer duodenal ulcer(18.1%), esophageal varix bleeding(12.7%), gastric cancer(9.1%) and Mallory-Weiss syndrome(l. 8%). 9) Eleven cases of UGI-hemorrhage were died from esophageal varix bleeding, hepatic failure and hepatic failure with re-bleeding of esophageal varix.

간흡충 감염가토의 담관에 대한 병리조직학적 변화 및 Lectin 반응에 관한 연구

양웅석(Ung Suk Yang),조몽(Mong Cho),백태현(Tae Hyun Paik),김상현(Sang Hyun Kim),주형준(Hyung Jun Joo),이동필(Dong Phil Lee),송근암(Geun Ahm Song),문한규(Han Gyu Moon) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6

N/A Histopahological and histochemical studies were done in the bile ducts of clonorchis sinensis (CS) infested rabbits. The duration of clonorchis sinensis infestation in the rabbits was between 12 and 17 months and the number of clonorchis sinensis metacercariae which were infested orally was 50-150 per rabbit. Hematoxylin-eosin and avidin-biotin peroxidase complex lectin staining methods were used for this study. Pathological changes of the bile ducts of CS-infested rabbits were papillarv and adenomatous hyperplasia, goblet cells and mucus cells rnetaplasia, ductal wall fibrosis and infitra tion of eosinophils in the ductal wall. These pathological changes were noted both in peripheral and central protion of bile duct. The pathological changes of hyperplasia and metaplasia of ductal epithelium were more marked in the deep gland than surface one, and dysplasia of the epithelium was more marked in the suface gland than deep one. In clonorchis sinensis infested rabbits, the lectins of Soybean agglutinin (SBA), Dolichos biflours agglutinin (DBA) and Ulex europaeus agglutinin (UEA I) were labelled predominant]y in the luminal suface, supranuclear protion of epithelium, goblet cells, hyperplastic cells and metaplastic cells of deep gland . SBA and DBA were labelled weakly to intermediate and UEA I was labelled weakl y to strong, but Peanut agglutnin (PNA) was ]abelled very weakly to those sites in CS-infested rabbits. In non CS infested rabbits, lectins of SBA, DBA, and UEA I were only weakly labelled in the luminal surface of epithelium. In this study, IJEA i which binds specifically glycoprotein of fucose was more pronounced in rabbits infested with CS and so it is postulated that increased activity of fucosyl transferase should be associated with CS infestation.

기능성 소화불량증과 기능성 변비를 동시에 호소하는 환자에서 주석산 시사프리드의 증상 개선 효과 및 안전성

양웅석(Ung Suk Yang),조중현(Joong Hyean Cho),구자영(Ja Young Koo),이광웅(Kwang Ung Ri),조성락(Seoung Rak Cho),한상영(Sang Young Han),박희욱(Hee Ug Park),송근암(Geun Am Song),주형준(Hyung Jun Chu),김도하(Do Ha Kim),이준상(Joon Sang Le 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.1

N/A Backgrounds/Aims: This study was performed prospectively to evaluate the short - term effect of cisapride tartrate on the frequency and the degree of symptoms in patients with functional dyspepsia and functional constipation. Methods: One-hundred thirty-two patients with a mean age of 44.7 years in men and 43.1 years in women, who presented with symptoms of both functional dyspepsia and functional constipation were recruited, and the frequency and the degree of symptoms corresponding to functional dyspepsia and functional constipation were assessed by an interview in 10 hospitals respectively. In an open, multicenter trial, 132 patients received 10 mg of cisapride tartrate three times a day (TID) for 8 weeks. Patients wrote a defecation diary for 8 weeks and checked symptom scores, which represented the degree of symptoms of dyspepsia and constipation, at the 4th and 8th week. Results: The frequently reported symptoms of functional dyspepsia were epigastric fullness (2.34 0.80), bloating (2.05 0.82), early saety (1.67 0.99), anorexia (1.04 0.95) and nausea (0.94 0.93). The mean defecation frequency per week was 3.07 2.35 and patients showed subjective symptom scores as follows; 97.0 25.26 % in the rate of sense of incomplete evacuation, 1.85 0.73 in the hardness of stool and 1.62 0.57 in difficulty to pass stool. After adminstration of cisapride tartrate in the case of functional dyspepsia, 66.1% of patients at the 4th week and 81.5 % of patients at the 8th week showed good or excellent improvements. In the case of functional constipation, 82.7%of patients also showed good or excellent improvements. Overall improvements of symptoms in both functional dyspepsia and functional constipation were 78.2% at the 8th week. Conclusion: Cisapride tartrate reduced the frequency and the degree of symptoms in functional dyspepsia and functional constipation without significant adverse effects.(Korean Journal of Gastrointestinal Motility 2001;7:36-46)

양성 식도협착에 부우지 및 풍선확장술의 효과

양웅석(Ung Suk Yang),박승근(Seung Keun Park),강대환(Dae Hwan Kang),송철수(Chul Soo Song),송근암(Geun Am Song),조몽(Mong Cho) 대한내과학회 1998 대한내과학회지 Vol.54 No.5

N/A Objectives: The causes of benign esophageal stricture were postoperative, corrosive, peptic and after esophageal sclerotheraphy, etc. The patients mainly suffered from dysphagia and insufficient nutrition. Recently, balloon and bougie dilatation were introduced to these patients. This study was performed to evaluate the effectiveness and safety of both procedures in different types of strictures Methods: 32 patients who presented dysphagia enrolled from March 1996 to August 1997 who visited Pusan National University Hospital. Balloon dilatation was performed on 22 patients and bougie on 10 patients. Results: 1) The causes of stricture were postoperative (18 cases), corrosive (10 cases), hypertensive LES (2 cases), peptic (1 case) and web (1 case). 2) Overall cure rate was 59% in e dilatation and 40% in balloon dilatation 3) The cure rate of postopertive stricture was 59% which is significantly higher than that of corrosive stricture (27%), and cure rate of hypertensive LES peptic stricture and web was 100%. 4) Tje cure rate of carrosive stricture was significantly higher on bougie dilatation than balloon dilatation. 5) The cure rate of postoperative stricture was similiar between balloon and bougie dilatation 6) The length of stricture was inversly affected on cure rate of both dilatation procedures. 7) Overall complication was 5.6% and similiar between balloon and bougie dilatation. Conclusions: These results suggested that bougie dilatation was recommended on corrosive stricture and balloon dilatation on postopertive stricture

공간점유간병소 및 췌병소에 대한 초음파 유도하 세침흡입 세포진에 관한 연구

양웅석(Ung Suk Yang),조중현(Joong Hyeon Cho),김영훈(Young Hoon Kim),강영진(Young Jin Kang),이강희(kang Hee Lee),허윤(Yun Huh),문한규(Han Kiu Moon),유방현(Bang Hyeon Liu) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1

N/A Liver biopsy by Menghini technique has a relatively low sensitivity and high risk in diagnosing space occupying lesions of the liver. Moreover, any biopsy method except exploratory laparotomy has not been useful in pancreatic lesions. Recently ultrasonically guided percutaneous fine needle aspiration cytodiagnosis is widely used in evaluating space occupying lesions of the liver and deep-seated organ, such as pancrea, because of its high sensitivity, safety and simplicity. Ultrasonically guided percutaneous fine needle aspiration cytodiagnosis was carried out to evaluating its diagnostic performance in 20 patients with space occupying lesions of the liver and in 3 patients with pancreatic lesions who were admitted to the Pusan National University Hospital from Oct. 1985 to Jan. 1986. The results were as follows: 1) Clinically diagnosis before ultrasonically guided percutaneous fine needle aspiration cytodiagnosis were primary hepatoma in 16 patients, liver abscess in 2 patients, hepatic cyst in 2 pateints, pancreatic cancer in 2 patients. 2) The cytodiagnosis in space occupying lesions of liver were as follows: The 14 patients of the 16 patients with clinically primary hepatoma were positive. All of the 2 patients with suspected liver abscess were confirmed. And all of the 2 patients with suspected heaptic cyst were same as clinical diagnosis. 3) The cytodiagnosis of the pancreatic lesions were as follows: Of the two patients with suspected pancreatic cancer one was positive and the negative patient were confirmed pancreatic cancer by the exploratory laparotomy. One patient with clinically pancreatic cyst was revealed as pancreatic cyst by the cytodiagnosis. 4) There was no complication in performing ultrasonically guided percutaneous fine needle aspiration cytodiagnosis.