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간흡충 감염가토의 담관에 대한 병리조직학적 변화 및 Lectin 반응에 관한 연구
양웅석(Ung Suk Yang),조몽(Mong Cho),백태현(Tae Hyun Paik),김상현(Sang Hyun Kim),주형준(Hyung Jun Joo),이동필(Dong Phil Lee),송근암(Geun Ahm Song),문한규(Han Gyu Moon) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
N/A Histopahological and histochemical studies were done in the bile ducts of clonorchis sinensis (CS) infested rabbits. The duration of clonorchis sinensis infestation in the rabbits was between 12 and 17 months and the number of clonorchis sinensis metacercariae which were infested orally was 50-150 per rabbit. Hematoxylin-eosin and avidin-biotin peroxidase complex lectin staining methods were used for this study. Pathological changes of the bile ducts of CS-infested rabbits were papillarv and adenomatous hyperplasia, goblet cells and mucus cells rnetaplasia, ductal wall fibrosis and infitra tion of eosinophils in the ductal wall. These pathological changes were noted both in peripheral and central protion of bile duct. The pathological changes of hyperplasia and metaplasia of ductal epithelium were more marked in the deep gland than surface one, and dysplasia of the epithelium was more marked in the suface gland than deep one. In clonorchis sinensis infested rabbits, the lectins of Soybean agglutinin (SBA), Dolichos biflours agglutinin (DBA) and Ulex europaeus agglutinin (UEA I) were labelled predominant]y in the luminal suface, supranuclear protion of epithelium, goblet cells, hyperplastic cells and metaplastic cells of deep gland . SBA and DBA were labelled weakly to intermediate and UEA I was labelled weakl y to strong, but Peanut agglutnin (PNA) was ]abelled very weakly to those sites in CS-infested rabbits. In non CS infested rabbits, lectins of SBA, DBA, and UEA I were only weakly labelled in the luminal surface of epithelium. In this study, IJEA i which binds specifically glycoprotein of fucose was more pronounced in rabbits infested with CS and so it is postulated that increased activity of fucosyl transferase should be associated with CS infestation.