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RISS 인기검색어
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- 저자 : 양민진(Min Jin Yang) (검색결과 3 건)
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율피.솔잎.호프의 수성 아세톤 추출물에 의한 Melanin 생성 억제 효과
양민진(Min Jin Yang),김명길(Myung Gill Kim),임세진(Se Jin Lim),안형수(Hyung Soo Ann),안령미(Ryoung Me Ahn) 대한약학회 1999 약학회지 Vol.43 No.4
The skin whitening effects of pine needle extract, hop extract and chestnut inner shell extract were evaluated both in vitro and in B 16 mouse melanoma cell lines. Each extracts significantly inhibited tyrosinase activity, dopa auto-oxidation and melanin biosynthesis in vitro and in B 16 cell lines. In vitro, hop extract inhibited melanin biosynthesis 15 times stronger than kojic acid at 10 mcg/ml concentration. Each extracts were stronger inhibitors of melanin biosynthesis than kojic acid in B 16 mouse melanoma cell at less than 4mcg/ml concentration. These results show that extracts of pine needle, hop and chestnut inner shell could be developed as skin whitening component of cosmetics.
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율피 추출물에 의한 Tyrosinase 활성억제 및 Melanin 생성억제 효과
양민진(Min Jin Yang),임세진(Se Jin Lim),안형수(Hyung Soo Ahn),김명애(Myoung Ae Kim),안령미(Ryung Me Ahn) 한국환경보건학회 1999 한국환경보건학회지 Vol.25 No.1
The inhibitory effects of chestnut bark extracts (CIS, CIS-gel, CIS jelly) were investigated in vitro and in B-16 mouse melanoma cells on melanin biosynthesis which is closely related to hyperpigmentation. These extracts inhibited tyrosinase activity which converts dopa to dopachrome in the biosynthetic process and the extracts inhibited the production of melanin from dopachrome by auto-oxidation. B-16 cells treated by chestnut bark extracts showed that the viability was over 85% in MTT assay. Melanin production was inhibited significantly by chestnut bark extracts in vitro and in B-16 cells. Especially CIS showed 15 times stronger inhibition of melanin production than kojic aicd in vitro. CIS-gel and CIS showed much stronger inhibition of melanin production under concentration of 4 ㎍/㎖ than kojic acid in B-16 cells. These results suggest that the chestnut bark extracts can be used for a whitening agent of the skin.
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만성 C 형간염바이러스 감염에서 Core 단백과 NS3 단백에 대한 말초혈액단핵세포의 면역반응
윤연숙,이기호,최요한,정숙향,양민진 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.3
Badqground/Aims' The aims of our study are to assess the frequency of peripheral blood mononuclear cell (PBMC) proliferation and cytokine profiles to hepatitis C virus (HCV) core protein and NS3 protein to search the potential immunosuppressive effect of HCV core in chronically HCV-infected patients. Subjects and Methods' Thirty two anti-HCV-positive patients with chronic liver diseases, eight HBsAg-positive patients with chronic liver diseases, and six healthy adults were the subjects of our study. Using recombinant HCV core and NS3, proliferative response of PBMC and cytokine production were determined. Results' Fifty nine percent and thirteen percent of patients with HCV-related chronic liver diseases showed positive PBMC proliferation to HCV core and NS3, respectively. Thirty four percent and fifty nine percent of patients with HCV-related chronic liver diseases showed significant production of interferon-gamma to HCV core and NS3, respectively. IL-4 production was negligible. When the PBMC were treated with HCV core and NS3 concurrently, or HCV core and phytohemagglutinin conaxvently, the stimulation indices were significantly decreased compared to those treated either with NS3 or PHA without core. Conclusions' Although about two thirds of chronically HCV-infected patients with liver diseases showed the PBMC proliferation and Th 1 type cytokine profile, they could not eradicate the viral infection. This ineffective immune response seems to play a role in the pathogenesis of chronic inflammatory liver disease resulting in liver cirrhosis and hepatocellular carcinoma. HCV core showed a potential immunosuppressive effect, which has important meaning for the mechanism of HCV persistence. (Korean J Hepatol 2001;7:292-298)
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