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알킬페놀 화합물의 HeLa cell (HL-60)의 세포독성에 대한 QSAR연구
김명길(Kim Myung-Gill),김재현(Kim Jae-Hyoun) 환경독성보건학회 2003 환경독성보건학회지 Vol.18 No.4
The purpose of the present study was to perform experiments of cytotoxicity using HeLa cell and to evaluate the possibility that QSAR is applicable 10 the cytotoxicity of alkylphenols. Higher toxicities were found in four alkylphenols in the following order: 4-n -Nonylphenol >4-tert-Octylphenol > 4-n-Octylphenol > 4-n-Heptylphenol. Whereas other alkylphenols were apparently less toxic. By using Percent Hydrophilic Surface Area (PHSA) quantitative structure-activity relationships (QSARs) models were developed: Cytotoxicity (%) = 90.14089-4.72224 PHSA (R²=0.2046, α=0.0265). It is concluded that some of the obtained data are useful to determine whether QSAR methods can be of general use in predicting that until further work is undertaken to develop QSARs for a much wider range of homologous series of alkylphenol compounds.
율피.솔잎.호프의 수성 아세톤 추출물에 의한 Melanin 생성 억제 효과
양민진(Min Jin Yang),김명길(Myung Gill Kim),임세진(Se Jin Lim),안형수(Hyung Soo Ann),안령미(Ryoung Me Ahn) 대한약학회 1999 약학회지 Vol.43 No.4
The skin whitening effects of pine needle extract, hop extract and chestnut inner shell extract were evaluated both in vitro and in B 16 mouse melanoma cell lines. Each extracts significantly inhibited tyrosinase activity, dopa auto-oxidation and melanin biosynthesis in vitro and in B 16 cell lines. In vitro, hop extract inhibited melanin biosynthesis 15 times stronger than kojic acid at 10 mcg/ml concentration. Each extracts were stronger inhibitors of melanin biosynthesis than kojic acid in B 16 mouse melanoma cell at less than 4mcg/ml concentration. These results show that extracts of pine needle, hop and chestnut inner shell could be developed as skin whitening component of cosmetics.
Aglycone유도체의 구조활성에 의한 생물활성도의 예측
김명길,김재현 동덕여자대학교 2002 생활과학연구 Vol.7 No.-
This study investigated to predict the activities of biological endpoints for the aglycones such as daidzein, glycitein and genestein, using QSAR software (PASS program). Also, activities of biological endpoints were measured for aglycones, and the effects of addition of OH substituents on 9 different endpoints were analyzed using the same QSAR procedures. Position-specific effects according to certain substitution patterns by the addition of OH substituents on the ring moiety showed equivalent or slightly higher than that of the unsubstituted aglycones of biological endpoints with increasing number as well as certain substitution patterns of OH. However multi-substituted daidzein showed an carcinogen activity lower than that of the unsubstituted one.
박테리아(E. Coli)의 AGB(alpha-glucosidase biosynthesis)를 이용한 중금속의 독성시험과 풀빅한에 의한 독성 억제효과
김재현,김명길,엄애선 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.1
Aim of the present study was the development of a bioassay which enables the detection of toxic effects of heavy metal ions to a bacterium, Escherichia coli. Inhibition effects of the metals on growth rates of the bacterium were studied in the absence or presence of fulvic acid. This method does not clearly differentiate among metals, hut does detect overall AGB inhibition rate (toxicity) for 5 different heavy metals. The toxicity of the metals in the absence of fulvic acid in the same testing conditions was significantly increased in following order: Hg<Ph, Zn<Cd<Cu, whereas the inhibition rate(toxicity) in the presence of FA was shown to be increased in following order: Cd<Ph, Hg<Cu<Zn. The results of the present study indicate that this simple and fast biomonitoring assay with direct exposure of E coli. might be a valuable supplement to analytical methods of contaminated media.