아토피피부염 병변에서의 CCL1의 특이적 발현

안인수 ( In Su Ahn ),김혜원 ( Hye One Kim ),박천욱 ( Chun Wook Park ),이철헌 ( Cheol Heon Lee ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.5

Background: Chemokines represent a superfamily of small cytokine-like chemoattractive proteins, which regulate leukocyte trafficking under homeostatic and inflammatory conditions. There have been previous reports that chemokine (C-C motif) ligand 1 (CCL1), a member of the family of chemoattractive proteins, is increasingly expressed in atopic dermatitis. Objective: We aimed to evaluate the quantity and the pattern of CCL1 expression in atopic dermatitis (AD). Methods: Biopsy specimens were taken from atopic skin and normal-appearing skin of AD patients as well as psoriatic skin of psoriasis patients. Quantitative real-time PCR analyses and immunohistochemistry of CCL1 expression were performed, and the quantity of CCL1 expression in acute AD was compared with those of normal-appearing atopic skin and psoriatic skin. The serum level of CCL1 was measured by ELISA. Results: CCL1 was most often expressed in acute atopic skin lesions, and the absolute amount of CCL1 18s rRNA in lesional atopic skin was 14.5-fold higher than that in non-lesional atopic skin. Moreover, CCL1 was expressed within the basal layer of the epidermis as well as in the dermis of the lesional atopic skin. However, CCL1 was expressed mostly in the dermis. Conclusion: Therefore, CCL1 represents a chemokine that is associated with flare-up of AD, and it may play an important role as a trigger of AD in the initiation and amplification of atopic skin inflammation in the acute phase. (Korean J Dermatol 2011;49(5):393∼397)

왼쪽 다리에 발생한 낭종형 에크린 나선종

안인수 ( In Su Ahn ),정보영 ( Bo Young Chung ),이희봉 ( Hee Bong Lee ),최지훈 ( Ji Hoon Choi ),안혜경 ( Hye Kyoung Ahn ),김혜원 ( Hye One Kim ),박천욱 ( Chun Wook Park ),이철헌 ( Cheol Heon Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.5

Eccrine spiradenoma is a benign tumor that is differentiated into the direction of an eccrine gland. It is usually presents as a solitary, slowly-growing, intradermal or deeply subcutaneous nodule on the head and trunk. We report on a case of 32-year-old woman with a solitary, solid mass on the left leg that she`d had for 6 months. The mass was a 2.5×2×0.5 cm sized, round shaped, well demarcated solitary skin-colored nodule. The mass in our case was a relatively large and painful eccrine spiradenoma, and the mass showed cystic formation. The cyst was surrounded by cords of tumor cells. Hyaline materials were seen focally. There were two types of cells. Large pale nuclei existed adjacent to the cyst. Small dark nuclei existed at the periphery. To clarify the histogenesis of this tumor, immunohistochemical staining using various antibodies was also performed. We herein report on an unusual case of a large cystic eccrine spiradenoma. (Korean J Dermatol 2010;48(5):409~412)

논단 (1) - 도시 공원 녹지의 소나무 군락식재 적정 모델개발과 적용(1)

한봉호,안인수,Han, Bong Ho,Ahn, In Su 한국조경수협회 2013 造景樹 Vol.132 No.-

산지형 도시공원 내 보행약자를 위한 산책로 조성 연구 -우면산도시자연공원을 대상으로-

한봉호,배정희,안인수,이경재,Han, Bong-Ho,Bae, Jung-Hee,Ahn, In-Su,Lee, Kyong-Jae 한국조경학회 2009 韓國造景學會誌 Vol.36 No.6

This study was undertaken to provide a basis for planning trail standards, providing rights of movement, improvement of health and the experience of nature for at-risk walkers for application to the Umyen Park site. This study researched related laws, manuals, scholastic writing and the established site, a raku-raku mountain trail in Osata, Japan. By referencing these results and similar standards, a conceptual trail plan for at-risk walkers was created. The plan suggests five points -- accessibility, convenience, social aspects, economic efficiency, and environmentally-friendliness -- and referenced an evaluation of outdoor living environments for the elderly. The planning standards are comprised of four steps that are ranked in order and are related to the selection of location, trail structure, route patterns, and equipment. Plans for trails catering to at-risk walkers in Umyen Park were then based on these standards. As a result, it was found that the mountain has both a high elevation and abundant natural resource, both of which must be taken into account during planning. This study is valuable because it is one of the first studies of trail plans for at-risk walkers made in mountainous urban parte. Subsequent research can use the standards of this study for further evaluation while future modifications must reflect changing needs and details. 본 연구는 보행약자의 이동권 확보와 건강증진 및 체험공간 제공을 위하여 산지형 도시공원성 기준 내 산책로 조성을 목적으로 조성기준을 수립하고 실제 사례지에 적용하였다. 문헌 및 사례연구를 바탕으로 보행약자 산책로 조성의 개념을 제시하고 관련된 유사기준을 참고로 산책로 조성 기준을 마련하였다. 보행약자 산책로 조성 개념은 노인주거시설 외부환경 설계 개념을 근거로 접근성, 편의성, 사회성, 경제성, 자연친화성의 5가지로 제시하였고 조성단계별 적용방안을 도출하였다. 산책로 조성 기준은 순서에 따라 입지적지 선정, 노면구조 설정, 노선배치, 시설배치의 네 단계로 구분되며 각 단계별 조성 기준을 제시하였다. 산책로 조성 기준을 우면산도시자연공원에 적용하여 보행약자 산책로 조성입지 선정, 노선배치 및 시설배치를 실시하였다. 그 결과 조망점과 탐방자원이 풍부한 산지에 완경사의 산책로 조성은 한계가 있었으나 우리나라 보행약자 산책로 조성의 초기 연구인 점에서 본 연구의 가치가 있으며 향후 본 연구결과를 기초로 산책로 조성을 실시하고 이용 후 연구를 통해 세부적인 사항들에 대한 심도 깊고 현실성 있는 기준 제시가 필요하였다.

만성 두드러기 환자에서 자가혈청 피부반응 검사와 Helicobacter pylori 감염에 관한 연구

최지훈 ( Ji Hoon Choi ),안인수 ( In Su Ahn ),이희봉 ( Hee Bong Lee ),김혜원 ( Hye One Kim ),박천욱 ( Chun Wook Park ),이철헌 ( Cheol Heon Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.7

Background: Although the pathogenesis of chronic idiopathic urticaria (CIU) has not yet been fully elucidated, previous studies have identified functional histamine-releasing autoantibodies against the α-subunit of the high affinity IgE receptor (Fc εRI) and Helicobacter pylori (H. pylori) infection. Objective: To investigate a possible association of autoimmunity and H. pylori infection with chronic idiopathic urticaria. Methods: We prospectively performed autologous serum skin tests (ASST) and urea-breath tests (UBT) on patients with CIU. We also checked clinical features. Amoxicillin and clarithromycin combined with a proton pump inhibitor was administrated as therapy for 1 week to patients that were UBT positive. We rechecked the UBT test 4 weeks later and rechecked the clinical features 6 weeks after eradication of the infection. Results: A positive result to the ASST was experienced by 56 patients (39.2%) with CIU; UBT was found in 48 patients (62.5%) with CIU. There were no significant differences in clinical features between patients with positive tests and those with negative tests. After eradication, 26 of 30 (86.7%) patients that were UBT positive showed significant clinical remission of the urticaria. Conclusion: According to our results, ASST is not helpful for predicting the severity or clinical course of CIU, but eradication of H. pylori in patients with chronic urticaria induces clinical remission of the urticaria. (Korean J Dermatol 2009;47(7):798~802)

태양광입지선정을 위한 지형분석방법 소개 및 영향분석

김영득(Kim, Young-Deug),안인수(Ahn, In-Soo),김민수(Kim, Min-Su),장정호(Chang, Jeong-Ho),장문성(Chang, Moon-Soung) 한국신재생에너지학회 2008 한국신재생에너지학회 학술대회논문집 Vol.2008 No.10

In design PV(photovoltaic) system, there are many important factors to consider for best site selection. It is essential to understand to know the amount of sunlight available and how to minimize the shadings. This study presents basic concepts for understanding sun's position and insolation. also gives easy tools for topography analysis. Finally, this study shows some theoretical calculations of power generation losses and disadvantages in economic feasibility.

태양광입지선정을 위한 지형분석방법 소개 및 영향분석

김영득(Kim, Young-Deug),안인수(Ahn, In-Soo),김민수(Kim, Min-Su),장정호(Chang, Jeong-Ho),장문성(Chang, Moon-Soung) 한국신재생에너지학회 2008 신재생에너지 Vol.4 No.4

In design PV (photovoltaic) system, there are many important factors to consider for best site selection. It is essential to understand to know the amount of sunlight available and how to minimize the shadings. This study presents basic concepts for understanding sun's position and insolation. also it gives easy tools for topography analysis. Finally, this study shows some theoretical calculations of power generation losses by topographic obstacle's elevations and disadvantages in economic feasibility, that is about 7million won loss per year for case of 10 degree topography elevation with assuming average Korea's topography elevation as 5 degree.

소아청소년 아토피피부염 환자의 삶의 질

조수익 ( Soo Ick Cho ),김진혜 ( Jin Hye Kim ),정보영 ( Bo Young Chung ),안인수 ( In Su Ahn ),김혜원 ( Hye One Kim ),박천욱 ( Chun Wook Park ),이철헌 ( Cheol Heon Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.5

Background: The symptoms of atopic dermatitis (AD) can limit a patient`s physical and psychosocial development as well as lower their overall quality of life (QOL). These problems may have a greater effect on patients during childhood and adolescence, whose physical and psychosocial developments are vigorously ongoing. Objective: The purpose of this study was to identify the correlation between the QOL and clinical disease severity in children and adolescents with AD. Methods: Forty-six AD patients aged from 7 to 18 years were included in this study. A questionnaire based on Children`s Dermatology Life Quality Index (CDLQI) was used to determine QOL. Eczema area and severity index (EASI) were examined to evaluate the severity of AD. Results: The mean score of CDLQI was 12.83±6.52. Among the 10 categories, itching, treatment, and sleep showed the highest scores, whereas teasing, friendships, and school or holiday work had the lowest scores (p<0.01). The mean EASI score was 8.51±8.64. CDLQI and EASI scores showed significant correlation (p<0.001). Among the 10 categories of CDLQI and EASI score, the sleep, itching, and clothes categories displayed high correlation with the EASI score (p<0.001). There was no statistically significant difference between the different age groups or between boys and girls. Patients with head and neck skin lesions showed problems with personal relationships and treatment (p<0.05). Conclusion: AD affects the QOL of children and adolescents with AD as the severity of the disease increases. In managing AD patients, not only evaluating the clinical severity of the disease but also evaluating QOL is necessary, and emotional support could be helpful to increase the QOL of childhood and adolescent AD patients. (Korean J Dermatol 2011;49(5):415∼421)

눈 주변에 발생한 알레르기 접촉 피부염 3예

이희봉 ( Hee Bong Lee ),정보영 ( Bo Young Chung ),안인수 ( In Su Ahn ),김혜원 ( Hye One Kim ),박천욱 ( Chun Wook Park ),이철헌 ( Cheol Heon Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.5

The use of ophthalmic drugs and contact lens solutions has increased and allergic contact dermatitis due to these agents has also recently increased. The first case was a 67-year-old female patient who developed allergic contact dermatitis after application of Latano(R): The patch test with the ingredients in Latano(R) showed positive reaction to latanoprost and benzalkonium chloride. The second case was a 63-year-old female patient who developed allergic contact dermatitis after application of Ecolicin(R), Tolon(R), Forus(R) and Uniten-F(R): The patch test showed a positive reaction to Tolon(R). She didn`t want further evaluation. The third case was a 51-year-old female patient who developed allergic contact dermatitis after application of Terramycin(R) eye ointment: the patch test with the ingredients of Terramycin(R) eye ointment showed a positive reaction to polymyxin B. When contact dermatitis occurs in periorbital areas, topical ophthalmic ointment or lens cleanser needs to be considered as a causative agent. (Korean J Dermatol 2010;48(5):429~434)

두피에 발생한 에크린 한공종 2예

정보영 ( Bo Young Chung ),조수익 ( Soo Ick Cho ),안인수 ( In Su Ahn ),김혜원 ( Hye One Kim ),박천욱 ( Chun Wook Park ),이철헌 ( Cheol Heon Lee ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.8

Eccrine poroma is a benign neoplasm that originates from an eccrine sweat duct. Although it is most commonly found on the soles of the feet, it has also been unusually observed on many other areas of the skin, such as the nose, neck, chest, and scalp. We report two cases of eccrine poroma occurring on the scalp, which is an unusual location. (Korean J Dermatol 2011;49(8):768∼771)