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- 저자 : 안은모(Un Mo Ahn) (검색결과 4 건)
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서남원(Nam Won Seo),이천준(Cheon Jun Lee),김도형(Do Hyung Kim),안은모(Un Mo Ahn),여태홍(Tae Hong Yeo),김준홍(Jun Houg Kim),안선의(Sunn Ie Ahn),김동휘(Dong Hwi Kim),박은동(Un Dong Park) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.1
목적: 본 연구는 난소의 악성 생식세포종의 임상 병리학적 특징과 이에 따른 재발율 및 생존율을 알아보아 치료에 있어서 논란이 되는 여러 문제점들을 고찰하고자 함에 있다. 대상 및 방법: 1991년 8월부터 1998년 11월까지 고신대학교 부속 복음병원 산부인과에서 난소의 악성 생식세포종양으로 진단 및 치료 받은 환자 31명을 대상으로 조직학적 분포, 연령, 병기, 임상증상, 종양표지물질, 치료 방법, 추적 관찰의 결과등에 대해 후향적 조사를 하였다. 결과: 이 기간내에 전체 난소 악성종양에서 악성 생식세포종양이 차지하는 비율은 6.37%였다. 조직학적 분포로는 미성숙기형종이 10예(32.3%)로 가장 많았고 미분화배세포종 8예(25.8%) 내배엽동종양 7예(22.6%), 혼합배세포종 및 융모상피암이 각각 3예(9.7%)였다. 평균 발생 연령은 24.26세(10∼40세)였고 가장 흔한 증상은 복부동통(38.7%)이었다. FIGO 병기로는 Ⅰ기가 18예(58.0%)로 가장 많았고, Ⅲ기 5예(16.2%), Ⅱ기 3예(9.6%) 순이었다. 모든 대상 환자에서 초기 치료로 수술이 시행되었으며 9명의 환자에서 이차추시개복술 및 시험적 개복술이 시행되었고, 술후 보조적 항암화학요법으로는 VAC, VBP, EP, BEP, EMA와 EMA CO 복합항암화학요법이 투여되었다. 평균 추적 관찰기간은 26.0(±S.D.;±20.3)개월이었고, 2년 및 5년 생존율은 각각 91.97%(±S.E.;±0.05) 및 86.86%(±S.E.;±0.07)이었다. Objective: The purpose of this study was to review the clinicopathologic features, recurrent rate, survival rate and controversable issues in the treatment of the ovarian malignant germ cell tumors. Patients and Methods: From August, 1991 to November, 1998 thirty-one patients with malignant germ cell tumors of the ovary treated in the department of obstetrics and gynecology, Kosin University Medical college, were eligible and assessable. Demographic characteristics, symptoms, signs, stage, tumor grade, mode of therapy and results of follow up were reviewed retrospectively. Results: The patients with malignant germ cell tumor constituted 6.37% of all ovarian malignancies during this period. Histologic subtypes were 8 dysgerminoma(25.8%), 7 endodermal sinus tumor(22.6%), 10 immature teratoma(32.3%), 3 mixed germ cell tumor(9.7%), 3 choriocarcinoma(9.7%). The age of the patients ranged from 10 to 40 years (mean ±S.D.; 24.26 ± 7.51). The most common symptom was abdominal pain(38.7%). Most had stageⅠ(18 cases, 58.0%) or stageⅢ(5 cases, 16.2%) diseases. All patients underwent surgery as the initial treatment, and nine patients received more than one operation. Postoperative adjuvant chemotherapeutic regimens were VAC, VBP, EP, BEP, EMA, and EMA CO. The mean follow up duration was 26.0(± S.D.; ± 20.3) months. The 2-year and 5-year survival rate were 91.97%(± S.E.; ± 0.05) and 86.86%(± S.E.; ± 0.07).
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강태경(Tae Kyoung Kang),서남원(Nam Won Seo),김도형(Do Hyung Kim),안은모(Un Mo Ahn),여태홍(Tae Hong Yeo),김준홍(Jun Hong Kim),안선의(Sune Ie Ahn),김동휘(Dong Hwi Kim),박은동(Un Dong Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3
N/A Objective: The human MAGE 3 gene encodes tumor specific antigens that are recognized by autologue cytotoxic T lymphocytes (CTL). The MAGE 3 gene is expressed not only in melanoma but in the other malignant tumors as well. There is, however, little information on the expression of the gene in uterine cervical carcinomas. The author thus studied the expression of the MAGE 3 gene products in uterine cervical carcinoma and discuss the possibility of specific immunologic diagnosis using MAGE 3 gene products. Methods: The expression of MAGE 3 gene product in 17 normal tissues of the cervix, 32 cervical intraepithelial neoplasia (8 CINⅠ, 10 CINⅡ, 14 CIS), and 43 invasive cervical carcinomas was studied by immunohistochemistry using anti-MAGE 3 mAb 57B in paraffin sections. Results: No expression of MAGE 3 gene product was detected in normal cervical tissues and in cervical intraepithelial neoplasias. The expression of MAGE 3 gene product was detected in 30.2% (13/43) of invasive cervical carcinomas. The MAGE 3 gene product was stained as a cytoplasmic protein in cancer cells. No statistically significant differences were observed between MAGE 3 gene product expression status and clinicopathologic parameters. Conclusions: The MAGE 3 gene products was expressed in invasive cervical carcinoma tissues.
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김동휘,박은동,이천준,안은모,여태홍 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.3
Recently, the bcl-2 and p53 protein have been recognized as important factors that is contributed to programmed cell death. The objective of this study was to evaluate the prognostic significance of bcl-2 and p53 protein expression in uterine cervical carcinoma. The expression of bcl-2 and p53 in 59 cases of uterine cervical carcinoma (stage IB to IIB) were surgically treated from January 1993 to June 1994. The expression of bcl-2 and p53 was examined by immunohistochemical method using formalin fixed paraffin embedded tissue specimens. The 48 cases were squamous cell carcinoma and 11 cases were adenocarcinoma. The results were as follows: 1. The expression rate of bcl-2 protein was 28.8%(17/59) and there was no significant correlation between the expression of bcl-2 protein and the clinicopathologic parameters (histologic type, grade, FIGO stage, cervical invasion depth, lymph node metastasis, parametrial invasion, tumor size, neoadjuvant chemotherapy response, recurrence, survival). 2. The expression rate of p53 protein was 32.2%(19/59) and there was no significant correlation between expression of p53 protein and the clinicopathologic parameters. 3. There was significant correlation between and expression of bcl-2 and p53 protein (P 0.05). In conclusion, bcl-2 and p53 protein are thought to be possible factors in the carcinogenesis of uterine cervical carcinoma and correlate with progression of it. But further study will be required to clarify the role of bcl-2 and p53 in carcinogenesis of the uterine cervix.
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침윤성 자궁경부암조직에서 Ureaplasma urealyticum의 검출
김도형,김동휘,김준홍,강태경,박은동,여태홍,서남원,안은모,안선의 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
Objective : Mycoplasmas have been implicated in many diseases including cervicitis, urethritis, salpingitis, endometritis... and functioning as cofactors catalyzing the HIV disease state. The oncogenic potentiality of mycoplasma was only recently realized when they were shown causing chromosomal changes and in vitro cell transformations through gradual progressive chromsomal loss and translocation. Few study has been reported the prevalence of mycoplasma infection in human cancers and suggested that there was a connection between these organisms and human cancers. The objective of this study was to determine the relationship between Ureaplasma urealyticum infection and cervical cancer. Methods : The detection frequency of Ureaplasma urealyticum in 52 invasive cervical cancer tissues and 17 normal cervical tissues was studied using PCR. Results : U. urealyticum DNA was detected in 8 out of 52(15.4%) invasive cervical cancer tissues and 1 out of 17(5.9%) normal cervical tissues. No statistic significance was observed between the detection frequency of Ureaplasma urealyticum and clinicopathologic parameters. The prevalence of Ureaplasma urealyticum in invasive cervical tissues was 15.4% and this rate was higher than 5.9% in normal cervical tissues but there was no statistic significance. Conclusions : With respect to clinicopathologic parameters of cervical cancer, there was no significant relation between U. urealyticum infection and cervical cancer. There is, however, few study and case on cervical cancer internally and externally. It is considered that more studies on the subject with much cases should be made.
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