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오약순기산(烏藥順氣散)이 고혈압과 동맥혈관에 미치는 영향
신형섭,고흥,김호현,Shin, Hyung-Sup,Ko, Heung,Kim, Ho-Hyun 한국한의학연구원 2004 한국한의학연구원논문집 Vol.10 No.2
Objectives : This experiments were performed to determine the effect of OYakSoonGi-San extract on hypertension in spontaneous hypertensive rat and norepinephrine-induced arterial contraction in rabbit. Methods : In order to define the effect of OYakSoonGi-San extract on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of OYakSoonGi-San extract-induced relaxation, OYakSoonGi-San extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, $N{\omega}-nitro-L-arginine$, methylene blue or tetraethylammonium chloride. Results : Blood pressure was significantly decreased five days after administration of OYakSoonGi-San extract. The relaxation effect of OYakSoonGi-San extract was dependent on the presence of endothelium, showing that OYakSoonGi-San extract-induced relaxation was not observed in the strips without endothelium. Also OYakSoonGi-San extract-induced relaxation was significantly inhibited in arterial strips which were contracted by high $K^+$. OYakSoonGi-San extract-indeced relaxation was significantly inhibited by the pre-treatment of $N{\omega}-nitro-L-arginine$ or methylene blue, but it was not observed in the strips pre-treated with indomethacin or tetraethylammonium chloride. When additive application of $Ca^{2+}$ in arterial strips which were pre-contracted by norepinephrine in a $Ca^{2+}$-free solution, arterial contraction was increased. But contractile response to $Ca^{2+}$ was attenuated by pre-treatment of OYakSoonGi-San extract. Conclusions : These results demonstrated that OYakSoonGi-San could be applied effectively to hypertension and may inhibit agonist-induced contraction through an decrease influx of extra-cellular $Ca^{2+}$ by the formation of nitric oxide in the vascular endothelial cells.
신형섭,이규호,박종화,Shin, Hyoung-Sub,Lee, Kyu-Ho,Park, Jong-Hwa 한국농공학회 2009 한국농공학회논문집 Vol.51 No.3
The objective of this study was to investigate the basic relationships between spectral reflectance and varying concentrations of sediment in surface waters. An experimental method for determining suspended sediment concentration (SSC) in the water by use of a spectroradiometer above the water surface, in visible and near-infrared (NIR) wavelengths, is applied. The main advantage of the method is the direct comparison of spectral reflectance and the SSC, but it requires an accurate knowledge of the water body and sediment. Therefore numerous spectroradiometric measurements are carried out in situ measurements, for SSC, ranging from zero to 100 percentage and two types of sediment applied in the water tank. The results indicate that the suspended sediment causes increasing spectral reflectance response in waters. We observed that spectral reflectance increases with SSC, first at the lower wavelengths (430-480 nm), then in the middle wavelengths (570-700 nm), and finally, in the NIR domain (800-820 nm); a characteristic maximum reflectance appears at 400-670 nm. Relationships between the wavelength, integral value, and the SSC were evaluated on the basis of the regression analysis. The regression curve for the relation between the wavelength, integral value, and the SSC were determined ($R^2$>0.98). Finally, the specular wavelength can be estimated to recognize the sediment and to improve SC estimation accuracy in the water.
마그네슘합금(AZ31B) 판재의 마찰교반 점용접시 접합특성에 미치는 툴 속도의 영향
신형섭,정윤철,최광,Shin, Hyung-Seop,Jung, Yoon-Chul,Choi, Kwang 대한용접접합학회 2011 대한용접·접합학회지 Vol.29 No.2
In this study, the friction stir spot welding (FSSW) of Mg alloy sheets has been tried using an apparatus devised with a CNC milling machine to give the precise control of joining condition including tool speed. The probe tool used is made of hard metal and composed of cylindrical shoulder and pin parts. The variation of morphologies formed after the friction stir spot welding depending on the plunge speed of the tool were investigated at each rpm of tool. The history of the temperature distribution and the vertical load induced during the spot welding with friction time were measured by using an Infrared Thermal Imager (THERMA CAMTM SC2000) and a loadcell located below the specimen fixture, respectively. Tensile-shear tests were also performed to evaluate the fracture load of welded specimens. In order to characterize the friction stir spot welding of Mg alloy sheets, the variation of the fracture load was discussed on micrographic observations, temperature distribution during the FSSW according to the plunge speeds of tool.