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신현규,성현제,Shin, Hyun-Kyoo,Sung, Hyun-Jea 한국한의학연구원 1996 한국 한의학연구소 논문집 Vol.2 No.1
Oriental medicine is a traditional medical are that has maintained its medical system only in Korea, Japan and China, nowadays, it is required to systematize the Oriental medicine modernly as well as prove remedical value of it for public welfare and hygiene, medical studies about geriatric disease and ageing are valued highly in researchs of future medical service which were excuted by Korea, Japan and Germay. consequently, future - estimating project of the Oriental medicine which keeps and accent on research datas that have a curative effect highly must be constructed. in the cause of this, effieient and systematic subject selection should be preceded to accomplish an advisable planning of the Oriental medicine.
대학부속한방병원 및 국립의료원 한방진료부 뇌졸증환자에 대한 한방치료 현황 분석
신현규,Shin, Hyun-Kyoo 한국한의학연구원 1995 한국 한의학연구소 논문집 Vol.1 No.1
The clinical study was carried out on 1737 cases of inpatient and outpatient which have been diagnosed as C.V.A at hospital attached to 8 colleges of oriental medicine in Korea or National Medical Center from January 1st 1994 to December 31st 1994. The results were as follows; 1. In this study, the case of Occlusive C.V.D was 70.1%, Cerebral hemorrhage was 20.5%, Transient ischemic attack (T.I.A) was 5.3%, Subdural hemorrhage was 3.0%, Subarachnoid hemorrhage was 0.8% 2. It was confirmed by C.T (20%), E.K.G. (19%), X-ray (19%), Urinalysis (19%), Hematoscopy (20%). 3. The mean days of hospital treatment was 27.88 days, mean days of ambulation was 70.34 days. The mean days of hospital treatment of Occlusive C.V.D, Cerebral hemorrhage, T.I.A., Subdural hemorrhage, Subarachnoid hemorrhage were 25.79, 39.32, 12.49, 16.23, 23.40 days, respectively. The mean days of ambulation of Occlusive C.V.D, Cerbral hemorrhage, T.I.A., Subdural hemorrhage, Subarachnoid hemorrhage were 74.40, 93.68, 69.10, 29.75, 32.57 days, respectavely. 4. Oriental medical treatment of C.V.A was mainly Acupuncture (25%), Paper of Chinese herbs (22%), Chinese physiotherapy (14%), Extract of Chinese herbs (11%). 5. Oriental medical physiotherapy for C.V.A was mostly E.S.T., Kinesiatrics, electric negative therapy, others Aerohydrotherapy, interferential current therapy (I.C.T.), Carbon, Samhogi, T.E.N.S., Ultra-sound, Infra-red, Microwave, T.D.P., Ultraviolet, S.S.P., Chinese herbs beth, Prarffin bath, Magnetic treatment and tractions.
내부열원을 갖는 Top-vented 원통형 밀폐공간에서의 자연대류에 관한 실험적 연구
강권호,신현규,신치범,유재석,김철,박영무,Kang, Kweon-Ho,Shin, Hyun-Kyoo,Shin, Chee-Burm,Yoo, Jai-suk,Kim, Chul,Park, Young-Moo 한국에너지학회 1996 에너지공학 Vol.5 No.2
본 연구에서는 감손우라늄칩을 처리하기 전의 시험단계로서 감손우라늄칩의 산화처리시 발생되는 산화열에 의한 산화장치 내부의 온도상승 및 외부로의 열전달을 해석하기 위해 산화장치 내부에 히터를 설치하여 실험을 수행하였다. 히터의 발생열량을 달리하면서 시간에 따른 열전달 특성을 알아내기 위하여 열유속, Nusselt 수, Grashof수와 Rayleigh 수를 구하고, Nusselt 수와 Rayleigh 수의 관계를 구하였다. An experimental study was conducted on the natural convection heat transfer with a heat source (heater) in a top-vented cylindrical enclosure. Using an Air Controlled Oxidizer (ACO) for treatment of depleted uranium chips, the heat transfer characteristics of the ACO was studied with various heat generation. Heat flux, Nusselt number, Grashof number and Rayleigh number were obtained and the relation between Nusselt number and Rayleigh number was derived.
Herpes simplex 바이러스의 유전학적 특성에 관한 연구
강봉주,최환수,최선미,신현규,조동욱,박갑주,Kang, Bong-Joo,Choi, Whan-Soo,Choi, Sun-Mi,Shin, Hyun-Kyoo,Cho, Dong-Wuk,Park, Kap-Joo 한국한의학연구원 1995 한국 한의학연구소 논문집 Vol.1 No.1
In order to facilitate the molecular characterization of the Herpes simplex Virus types 1 and types 2 genome DNAs, a gene library of cloned restriction frtgments have been produced. The Vero cells were infected with HSV-1 and HSV-2. 48 hours after infection, the infected cells Ivere Iysed, and multinucleated giant cells were observed approximately at seventy-two hours postinfection. The multiplication of HSV-1 and HSV-2 was observed in Vero cells using electromicroscopy. The nucleocapsids in nuclei were obseryed, and the assembled virions were budded out through the vacuole, and the virions were released from the cells. HSV-1 and HSV-2 was analyzed by digestion of their genome DANs with restriction ensymes. HSV-1 and HSV-2 genome DNAs were digested with BarnHI, Bgfl respectively. The BarnHI rlestriction fragments of HSV-1 and HSV-2 genome DNAs were twenty-seven fragments and thair molecular sizes were ranging $0.70{\sim}15.08$, $4.4{\sim}31.0$ tilobases. The BglII restriction fragments of HSV-1 and HSV-2 genome DNAs were sixteen, eighteen fragments and thair molecular sizes were ranging $4.8{\sim}30.0$, $1.2{\sim}25.0$ kilobases. And then BglII restriction frgments were cloned in Escherichia coli(E.coil) using the plasmid vector pBacPAK9.
Chiness hamster lung cell(CHL)에서 십전대보탕 염색체 이상 시험
마진열,황대선,이남헌,하혜경,유영법,신현규,Ma, Jin-Yeul,Huang, Dae-Sun,Lee, Nam-Hun,Ha, Hye-Kyung,Yu, Young-Beob,Shin, Hyun-Kyoo 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.2
Objectives : This study was to assessment the toxicity of Sipjeondaebo-tang(Shiquan dabu-decoction) by Chromosomalanomaly test. Methods : Sipjeondaebo-tang(Shiquan dabu-decoction) water-extract in vivo Chromosomalanomaly test was performed using chiness hamster lung cell line. Results : Sipjeondaebo-tang water extract was negative in Chromosomalanomaly test at the doses of 0, 625, 1250 and $2500{\mu}g/m\ell$ at 6h and 24h.(S9- fraction). Chromosomalanomaly test(S+fraction) was also negative at the doses of 0, 1250, 2500 and $5000{\mu}g/m\ell$. Conclusions : It was concluded that Sipjeondaebo-tang extract did not induce Chromosomalanomaly in the chiness hamster lung cell.
마충제,이남헌,마진열,하혜경,유영법,신현규,Ma, Choong-Je,Lee, Nam-Hun,Ma, Jin-Yeul,Ha, Hye-Kyung,Yu, Young-Beob,Shin, Hyun-Kyoo 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.2
Objective : The purpose of this report was to provide the information activity and safety of Palmul-tang by analyzing domestic/international papers and theses about Palmul-tang, Methods: Domestic/international papers and theses related to Palmul-tang were reviewed and analyzed, These papers were then classified by year, experimental method and subject, Results: The following results were obtained in this study. 1. The study of Palmul-tang started from 1985 and was continuously increased. The study was mainly forcused on experimental model rather than clinical study. 2. As these studies were classified by subject, papers related to immune intensification were most abundant by 20 papers, Besides there were several papers related to cardiovascular activity, reproductive activity, anti-apoptotic activity and cerebral hemodynamics. 3. Among the papers related to immune intensification. the studies on recovery of fatigue were mostabundant by 10 papers and the studies of on immune cell and cytokine express were six. In addition to. several studies were associated with anti-cancer activity and anti-allergic activity. Recovery of fatigue was determined by measurement of fatigue markers in a living body such as lactate. CPK, pyruvate and triglyceride and assessment of exercise capability of animals such as swimming test. slopped plate test. Rota-rod test, and activity cage test after Palmul-tang treatment. 4. According to experimental data. it is supported that Palmul-tang has been used as Qi and Blood intensifier with immune intensification and recovery of fatigue. 5. The paper related to safety of Palmul-tang was only one paper which is studied on acute toxicity of Palmul-tang with experiment with ICR mouse. There was no study on evaluating safety by observing liver and kidney functions after Palmul-tang treatment Conclusion: Palmul-tang is being used in various ways associating with immune intensification. cardiovascular activity and reproductive activity. However. studies on efficacy and mechanism of Palmul-tang should be conducted at the molecular biology level and studies on safety of Palmul-tang need to be completed at the clinical level.
ICR 마우스를 이용하여 사물탕(四物湯)의 급성 독성에 관한 연구
마진열,유영법,하혜경,황대선,마충제,신현규,Ma, Jin-Yeul,Yu, Young-Beob,Ha, Hye-Kyung,Huang, Dae-Sun,Ma, Choong-Je,Shin, Hyun-Kyoo 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.2
Objectives: Samul-tang(Siwu-tang) has been traditionally prescribed a medicine as a restorative. Methods: In this study, we investigated the acute toxicity about water-extracted Samul-tang(Siwu-tang). Twenty-five mice completed 14 days of oral Samul-tang(Siwu-tang) at the respective doses of 0(control group), 2560, 3200, 4000 and 5000mg/kg. Results: We observed survival rates, general toxicity, change of body weight, and autopsy. Conclusions: Compared with the control group, we could not find any toxic alteration in all treated groups (2560, 3200, 4000 and 5000mg/kg). $LD_{50}$ of Samul-tang(Siwu-tang) was over 5000mg/kg and it is very safe to ICR mice.