뇌지주막하 출혈 후 뇌혈관 연축에 대한 동맥내 Papaverine 주입의 치료효과

신준재,이재환,신용삼,허승곤,김동익,이규창,Shin, Jun Jae,Lee, Jae Whan,Shin, Yong Sam,Huh, Seung Kon,Kim, Dong Ik,Lee, Kyu Chang 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.3

Objective : To clarify the benefits and therapeutic effects of intra-arterial papaverine infusion on the symptomatic cerebral vasospasm, we analyzed the results of treatment in 32 patients retrospectively. Methods : A total of 510 patients underwent surgical clipping or endovascular intra-aneurysmal treatment for ruptured intracranial aneurysm between May, 1996 and June, 1999. The delayed ischemic deficit(DID) was developed in 90 of 510 patients. Of these 90 patients, 32 developed symptomatic vasospasm inspite of using modest "3H therapy". The brain CT scan was taken before the intra-arterial infusion of papaverine. The 32 patients underwent 42 intra-arterial papaverine infusion. The symptomatic vasospasm was divided into three groups : deterioration of mental status(Group 1), appearance of a focal neurologic deficit(Group 2), or both(Group 3). We measured Glasgow Coma Scale(GCS), arterial diameters, and cerebral circulation time(CCT) at the time of pre- and postangioplasty. Results : The number of patients in group 1, 2 and 3 were 26, 7, 9 respectively. Eighteen cases showed improvement of GCS more than 2 scores, 16 more than 1, and 8 showed no change of GCS. Average cerebral circulation time(CCT) was decreased ranging from 0.0%-67.5%, and arterial diameters were increased in 21 cases ranging from 1 to 4 folds. Conclusion : Intra-arterial papaverine infusion seemed to have therapeutic effects on symptomatic vasospasm by improving the neurological signs and increasing the arterial diameter. We suggest that intra-arterial papaverine infusion would be an useful adjunctive therapeutic modality in symptomatic vasospasm.

상위 경추 수질내의 신경절교종

신준재,오성한,윤도흠,김태승,Shin, Jun Jae,Oh, Sung Han,Yoon, Do Heum,Kim, Tae Seung 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.2

Gangliogliomas are benign tumors, composed of neoplastic astrocytes and nerve cells. They are rare, account for 0.4-6.25% of all primary central nervous system neoplasms. Gangliogliomas affect predominantly infants or young adults. Gangliogliomas are preferentially encountered supratentorially, predominantly affecting the temporal lobe. Spinal gangliogliomas affect predominantly the cervical spinal cord. We report a case of cervical ganglioglioma which was successfully removed surgically, with a review of literature.

신규 살조제 Thiazolidindione 유도체 (TD49)의 해양생물에 대한 생물 농축도 조사

신준재(Jun-Jae Shin),김시욱(Si-Wouk Kim),조훈(Hoon Cho),김성준(Seong-Jun Kim) 한국생물공학회 2012 KSBB Journal Vol.27 No.2

In this study, a newly synthesized thiazolidinedione derivative, TD49 with a highly selective algicide to red tide, was examined in order to evaluate the bioconcentration on aquatic organisms of coast. BAF (accumulation of TD49 by aquatic food chain) and BCF (accumulation of TD49 by sea water) were examined employing the shrimp (Fenneropenaeus chinensis) as the feed organism, and the olive flounder Paralichthys olivaceus as a consumer in marine ecosystem. Bioconcentration degree in sea water showed that the order in P. olivaceus was viscera > gill > muscle. The average BCF values of TD49 were 67.70, 63.32 and 20.25 at viscera, gill and muscle, respectively. Bioaccumulation degree using feed showed that the order in the organs of P. olivaceus was viscera > gill > muscle. The average BAF values of TD49 were 175.89, 114.88 and 32.59 at viscera, gill and muscle, respectively. When compared with two results, the accumulation by the food and water was higher than that by water. After the elimination experiment in sea water, the TD49 concentration was 2.81 nmole/g in the viscera and were not found in the gill and the muscle. More than 50% of the accumulated TD49 were eliminated from viscera in 7 days and all the accumulated TD49 were eliminated from gill and muscle in 7 days. On the other hand, the octanol/water partition coefficient (log Kow) was measured to be 3.66 and experimental BCF of this study was 67.7.

신규 살조물질인 Thiazolidinedione 유도체 (TD49)의 해양생태계에 대한 급성독성평가

임은채(Eun-Chae Yim),신준재(Jun-Jae Shin),박인택(In-Taek Park),한효경(Hyo-Kyung Han),김시욱(Si-Wouk Kim),조훈(Hoon Cho),김성준(Seong-Jun Kim) 한국생물공학회 2010 KSBB Journal Vol.25 No.6

A thiazolidinedione derivative, TD49 with the highly selective algicide to red tide was newly synthesized and its acute toxicity was examined in order to evaluate the effect on aquatic ecosystems of coast. Major three species having important role in the food chain of marine ecosystem, such as Skeletonema costatum of microalgae, Daphnia magna of crustacea, Paralichthys olivaceus of flatfish fingerling were employed for the acute toxicity assessment. EC50 or LC50 as the assessment criterion was investigated to each specie, and NOEC (No Observed Effect Concentration) and PNEC (Predicted No Effect Concentration) from most sensitive specie to toxicity of TD49 were further calculated. EC50 of S. costatum in 96-hour, EC50 of D. magna in 48-hour, and LC50 of P. olivaceus in 72-hour for TD49 were 0.34 μM, 0.68 μM, and 0.58 μM, respectively. NOEC from the results of S. costatum was estimated to be 0.20 μM and PNEC was estimated as 3.40 nM by applying factor value of 100 to EC50 0.34 μM of S. costatum. In addition, it was revealed that Solutol used as the dispersing agent of TD49 had very little toxic influence under the concentration range of 0~0.4 μM used in TD49 toxicity experiment. Although the estimated concentration of TD49 that will be sprayed onto the coastal field for the algicide is higher than NOEC value, it is considered that the spraying concentration would not be a considerable problem due to a dilution effect by tide at the opened coast.

신규 살조물질인 Thiazolidinedione 유도체 (TD53)의 해양생태계에 대한 급성독성평가

임은채(Eun-Chae Yim),신준재(Jun-Jae Shin),박인택(In-Taek Park),한효경(Hyo-Kyung Han),김시욱(Si-Wouk Kim),조훈(Hoon Cho),김성준(Seong-Jun Kim) 한국생물공학회 2011 KSBB Journal Vol.26 No.1

In order to perform an acute toxicity assessment of a new algicide, thiazolidinedione derivative (TD53) with enhanced solubility and lower toxicity to marine ecosystem, representative 3 organisms: plant plankton (Skeletonema costatum), animal plankton (Daphnia magna), fish (Paralichthys olivaceus) related in the food chain of marine ecosystem according to OECD standard methods were employed in the exposure experiment. The exposure assessment showed that EC50 of S. costatum in 96-hour, EC50 of D. magna in 48-hour and LC50 of P. olivaceus in 72-hour for TD53 were 1.53 μM, 0.61 μM and 2.14 μM respectively. NOEC (No Observed Effect Concentration) and PNEC (Predicted No Effect Concentration) were calculated to be 0.25 μM and 6.10 nM, respectively from EC50 of most sensitive strain, D. magna. Comparing with the results of toxicity assessment previously performed by using Ulva pertusa Kjellman accepted as an ISO standard method, the values of PNEC showed 3.7 times lower toxicity in case of this study employing 3 organisms, indicating that if the organisms which are more representative and sensitive in marine ecosystem are further investigated, more accurately and validly predicted toxicity of TD53 could be applied in field.

전두골에 발생한 방사선 속발 골육종 -증례보고-

강형래 ( Hyoung Lae Kang ),신준재 ( Jun Jae Shin ),박상근 ( Sang Keun Park ),황용순 ( Yong Soon Hwang ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2006 대한뇌종양학회지 Vol.5 No.1

This is a case of a 21-year-old woman who was treated primitive neuroectodermal tumor(PNET) when she was 12-yearold. At that time, we performed radical surgery, radiation therapy, and chemotherapy. Forehead mass has developed after 11 years. On computed tomography, high density mass was detected on frontal bone and this lesion was removed by surgical operation. After surgery, chemotherapy was done at two times. The histological diagnosis was postradiation osteosarcoma. Postradiation osteosarcoma is a rare complication of radiation therapy. It has histologically been high-grade and poor prognosis. However, complete remission was obtained in our case after a couple of surgical operation, chemotherapy. This is the first case of postradiation osteosarcoma to be reported in the domestic. We treated a patient who developed osteosarcoma in the frontal bone 11 years after radiotherapy for PNET in the cerebellum and achieved favorable outcome.

임상 : 신경정신과질환과 뇌하수체병변이 동반된 환자의 분석

김승국 ( Seung Kook Kim ),박상근 ( Sang Keun Park ),황용순 ( Yong Soon Hwang ),신준재 ( Jun Jae Shin ),신형식 ( Hyung Shik Shin ),김태홍 ( Tae Hong Kim ) 대한뇌종양학회 2011 대한뇌종양학회지 Vol.10 No.1

Purpose: The possible toxic effect of chronic neuroleptic drug on the neuroendocrine system has been well documented, and hyperprolatinemia is a common side-effect of antipsychotics. Recently we experienced 12 schizophrenic patients with pituitary lesions. It can be postulated that pituitary dysfunction may cause schizophrenia, or neuroleptic drugs may induce pituitary lesion in the patient with schizophrenia. We analyzed these patients and reviewed related literatures. Materiala and Methods: From October 2007 to April 2009, ten patients who had been treated at department of psychiatry under the diagnosis of schizophrenia (6 patients) and other psychiatric diseases (6 patients) were enrolled in this study. The pituitary lesions were detected by MRI and consulted to neurosurgical department. Various possible clinical information, medication history, radiological finding and result of neurosurgical management were analyzed. Result: Radiological findings of twelve patients with pituitary lesions were definite pituitary tumors in 6, cystic lesions in 3 and suspicious tumorous lesions in 3 patients. Medicated drugs at psychiatric department were risperidone, clozapine and other antidepressants. We had operated for 4 patients who had schizophrenia concomitant with definite pituitary tumors. After surgery psychological symptoms of these patients were improved in spite of minimized neuroleptic drugs. The pituitary lesions in the none operated patients were diminished or unchanged during the suitable observation period. Conclusion: Neuroleptic drug may act as toxic effect on pituitary gland by blocking predominantly dopamine receptors of the D2 class as well as other receptors to varying degrees. We experienced 10 psychiatric patients with pituitary lesions. It may be considered that neuroleptic drugs enhance pituitary lesions, or high prolactin level aggravates schizophrenic symptoms.