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아미노글리코사이드계 항생제의 투약간격에 따른 안전성 및 효과
이주은,김호순,신완균,조남춘,Lee, Ju Eun,Kim, Ho Soon,Shin, Wan Gyoon,Cho, Nam Chun 한국임상약학회 1998 한국임상약학회지 Vol.8 No.2
Improved knowledge of the time course of antimicrobial activity should provide useful information for designing optimal dosage regimen. In contrast to $\beta$-lactam, aminoglycosides tend to induce a prolonged postantibiotic effect against aerobic or facultative gram negative rods and clinical outcome was significantly correlated with achieving peak serum concentrations. The objective of this study was to compare the efficacy, safety of e same total daily dose of amikacin and gentamicin given either twice or thrice daily in the treatment of patients. Consecutive patients over 20 years old with a suspected or confirmed infection for which an aminoglycosides was indicated were eligible. Exclusion criteria were known allergy to aminoglycosides, renal impairment, granulocytopenia and pregnancy. Patients were treated with intravenous amikacin 15 mg/kg/day or gentamicin 4.5 mg/kg/day either in two devided or in three devided. Seventy-four patients with infection were enrolled in this study of amikacin twice daily (A2, n=29), gentamicin twice daily (G2, n=8) vs amikacin thrice daily (A3, n=30), gentamicin thrice daily (G3, n=7). Baseline characteristics were comparable in G2 and G3. The clinical cure rate (including partial improve) were $89.0\%\;and\;86.0\%$ in A2 group and A3 group respectively. The bacteriologic cure rate were $99.0\%\;and\;85.7\%$ in A2 group and in A3 group respectively. The clinical and bacteriologic effects were difficult to compare G2 with G3, because of the small numbers of patients. The serum creatinin rose in $3.44\%$ (1 in 29) of patients in the A2 group compared to $13.3\%$ (4 in 30) in e A3 group. Although audiometry was not performed, there was no clinical evidence of ototoxicity in any of the patients. In our opinion, twice-daily regimen of aminoglycosides is more effective and less nephrotoxic than thrice-daily regimen.
의사의 스테로이드 외용제 처방 현황 및 부작용 인지도에 대한 설문조사
박수진 ( Sujin Park ),최수안 ( Soo An Choi ),이주연 ( Ju-yeun Lee ),김은영 ( Eun Young Kim ),신완균 ( Wan Gyoon Shin ),김도영 ( Doyoung Kim ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.2
Background: Topical steroids are the most commonly prescribed anti-inflammatory agents in dermatology, and patients often experience various adverse events of topical steroid application. Patients’ awareness of adverse effects and understanding of coping strategies for these unwanted events are pivotal elements for the safe use of topical steroids. Objective: This study aimed to assess the prescribing pattern of topical steroids and patient education for safe use by dermatologists and non-dermatology specialists in Korea. Methods: A questionnaire was sent to dermatologists, pediatricians, and other specialists through an online survey. A total of 444 answers were analyzed; then, the numbers were adjusted according to the nationwide proportion of specialists prescribing topical steroids. The total number of respondents was set to 720 after the adjustment. Results: Dermatologists prescribed topical steroids to 49% of their patients, while other specialist doctors prescribed to 6.4% of the patients. Mid-potency steroids were most commonly prescribed (52.9%), followed by low/weak potency (37.6%), in adjusted analysis. Overall, 12.5% of all respondents and 14.5% of dermatologists reported adverse events due to topical steroids within the last month. The physicians spent 2.1 minutes on average (2.0 minutes for dermatologists) for patient education on proper use of topical steroids. The majority (79.1%) of physicians informed patients of the fact that the prescription contained steroids, while some were reluctant to disclose this information because of the negative perception about steroids in the general population. Conclusion: This survey provides thorough information on the current status of prescription, counseling condition, doctors’ perception of patients’ knowledge of adverse events, and proper use of topical steroids. (Korean J Dermatol 2021;59(2):100∼107)
식품의약품안전청의 의약품안전사용정보방 웹사이트 구축을 위한 컨텐츠 개발
지은희(Eunhee Ji),박효영(Hyo Yung Park),노혜진(Hyejin Noh),이동은(Dong Eun Lee),한나영(Nayoung Han),정소현(Sohyun Jeong),김인화(In-Wha Kim),신완균(Wan Gyoon Shin),오정미(Jung Mi Oh) 대한약학회 2012 약학회지 Vol.56 No.3
The purpose of this study was to construct database for a drug safety information website to serve as an access point of up-to-date resources for a wide variety of drug-safety information helping patients and healthcare professionals make well-informed decisions about medication use. All the contents developed were confirmed by the council of advisors who were the experts in drug safety. The detailed contents of database on frequently prescribed drug including 9 NSAIDs, 19 antibiotics, 24 cardiovascular, 21 metabolic, 14 respiratory, 20 digestive, 22 hormonal, 10 genitourinary, 10 anti-allergic, 27 antifungal/antiviral, and 71 neuropsychiatric agents were developed based on the approved drug labeling of the Korean FDA. A separately searchable database of drug-specific safety information for patients and health professionals was constructed for users in need of different depth of knowledge on using medications safely. The safety information on highly prevalent chronic diseases and drug classes was also developed. Finally the most recent global drug safety news was provided. The consumer directed information was developed in layman’s terms as means of proving user-friendly information. The creation of this type of website is part of the Korean FDA’s ongoing initiative to address and promote the safe use of medications for the public.
신완균,김양수,우준희,최강원 대한화학요법학회 1987 대한화학요법학회지 Vol.5 No.2
Vancomycin in an antibiotics produced by streptemyces orientalis. The emperical formula of vancomycin is C_(66) H_(75) Cl₂N₂O₄and molecular weight is 1,448. It has been in use as an antimicrobial agent for more than 20 years. Nonetheless, understanding of tis pharmacokinatic properties is incomplete. Recent novel clinical applications of vancomycin have stimulated reinvestigations of the pharmacokinetic properties of this drug. After intravenous administration, vancomycin is excreted by kidney, with virtually total recovery in urine. Distribution is consistent with a three compartment open pharmacokinetic toxicity, distribution, metabolism, haemodialysis, peritoneal dialysis and several diseases. The current review of protein binding of vancomycin show variety values as 55%, 53%, 65%, less than 10%. Our study of protein binding of vancomycin was 28.8±3.0% after evaluation of methodology & condition which may affect protein binding in method of equilibrium dialysis. Based on our study of protein binding of vancomycin by equilibrium dialysis, it is required to confirm equilibration depend on memberanes and volume shift.