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신성찬,김지민,권현근,천용일,이병주,Shin, Sung-Chan,Kim, Ji Min,Kwon, Hyun-Keun,Cheon, Yong-Il,Lee, Byung-Joo 대한후두음성언어의학회 2020 대한후두음성언어의학회지 Vol.31 No.2
Background and Objectives Presbyphonia is characterized by hoarse, breathy, weak vocal intensity. Extracellular matrix (ECM) in lamina propria (LP) of the vocal folds play an important role in voice production, and change of ECM according to the aging leads to the presbyphonia. The aim of this study was to investigate the histologic analysis of aging vocal fold of rat. Materials and Method Six and twenty two months old Sprague-Dawley rats (n=8, each group) were used and classified into young (six months old rats) and old (twenty two months old rats) group. Histologic analysis and immunohistochemical staining for ECM of LP were performed. Results Overall cellular density was significantly decreased in old rat group. Elastin fibers of LP were significantly decreased in old rat group. Type I collagen was significantly increased in old rat group. Type III collagen did not show significant difference. Hyaluronic acids did not show significant difference in Alcian blue staining and immunohistochemical staining. Conclusion Decreased general cellular density and elastin fiber and increased type I collagen were observed in the LP of vocal folds of aging rats. These ECM changes might to contribute the aging voice.
갑상선 수술 중 바늘과 피부 전극을 이용한 새로운 신경감시술
신성찬,서명구,천용일,이병주 대한갑상선학회 2022 International Journal of Thyroidology Vol.15 No.1
Intraoperative neuromonitorng (IONM) has gained wide acceptance as a useful adjunct in identifying andpreserving of recurrent laryngeal nerve (RLN) during thyroid surgery. The electromyographic endotracheal tube(EMG-ETT) method is the most widely used and well-validated method for thyroid IONM; however, malpositioningof the tube is a critical shortcoming of the EMG-ETT method. This is the main reason for the low positive predictivevalue of IONM in thyroid surgery. Needle and skin electrodes can obtain EMG signal regardless of patient positionand are easy to apply during surgery and is economical compared to EMG-ETT method. New IONM system usingneedle or skin electrodes would be an alternative method which can overcome shortcomings of EMG-ETT.
이하선, 측두골 및 안면신경을 침범한 침습 기저세포암 1예
신성찬,고의경,임윤성,이병주 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.4
Basal cell carcinoma (BCC) is the most common dermatologic cancer characterized by slow growing, less invasive and highly curable clinical course. But occasionally, BCC behaves aggressively with deep invasion and potential regional and distant metastasis. Several risk factors, including tumor size, duration, histologic type, and perineural invasion have been postulated as markers of the aggressive BCC phenotype. Tumors occuring along the nasolabial fold or the retroauricular area may be aggressive but that is still debated. Aggressive cases of BCC involving the parotid gland, the emporal bone and the facial nerve have been rarely reported. We report a case of aggressive basal cell carcinoma involving the parotid gland, the temporal bone, and the facial nerve with a review of the literature.
신성찬,이병주 대한이비인후과학회 부산,울산,경남 지부회 2017 임상이비인후과 Vol.28 No.2
From the year 2000, the Republic of Korea has entered an age society, where the proportion of elderly people over 65 is over 7%. Elderly patients require careful treatment because their overall physical function is diminished, the morbidity of comorbidity is high, and the incidence of complications is high. The comprehensive geriatric assessment is required to predict treatment related toxicity, and it can help physician and surgeon to make an optimal treatment plan for individual elderly patient. The purpose of this study is to evaluate the surgical management of patients with head and neck cancer.