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난알부민으로 알레르기 비염이 유발된 마우스에서 형개의 개선효과
송대욱 ( Dea Uk Song ),허준 ( Jun Heo ),이성엽 ( Sungyub Lee ),김재현 ( Jae Hyun Kim ),이비나 ( Bina Lee ),민주희 ( Ju Hee Min ),김은영 ( Eun Young Kim ),손영주 ( Youngjoo Sohn ),정혁상 ( Hyuk Sang Jung ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.6
Objectives : The aim of this study was to evaluate the effect of Schizonepeta Spica water extract (SS) on the OVA-induced BLAB/c mice allergic rhinitis model. Methods : Thirty two BALB/c mice were equally assigned to 4 groups; the sham group, the control group, the cetirizine hydrochloride (Cet) treatment group, and the SS treatment group. Sham group was sensitized and challenged with saline, and the other groups were sensitized and challenged with OVA. The dosage of SS was 7.6 mg /kg·day, and Cet was 10 mg/kg·day. Nasal rubbing and sneezing were measured by the behavior observation. The concentrations of IL-1β, IL-10, TNF-α and MIP-2 in the sera of allergic rhinitis model were measured by mouse cytokine/chemokine magnetic bead panel kits. Total IgE and OVA-specific IgE were measured by ELISA method. Epithelial thickness and eosinophil infiltration of nasal septum was investigated by histological examination. Results : The clinical symptoms that increased in control group were significantly reduced in SS-treated group. Serum total IgE and OVA-specific IgE in the SS-treated group were significantly reduced compared to the control group. The concentration of IL-1β, IL-10, TNF-α and MIP-2 in SS-treated group showed a significant reduction compared to the control group. The infiltration of eosinophil into nasal tissues of SS-treated group decreased markedly compared to control group, and thickness of nasal septum in nasal mucosa showed a significant reduction compared to control group. Conclusions : According to the above result, it is suggested that SS may inhibit the early and late phase of allergic rhinitis reaction.
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유향흑호단(乳香黑虎丹)이 난소적출로 유발된 흰쥐의 골다공증 모델에 미치는 영향
금창준 ( Chang Jun Kum ),조창영 ( Chang Young Cho ),임정민 ( Jeong Min Lim ),송대욱 ( Dea Uk Song ),김재현 ( Jae Hyun Kim ),이비나 ( Bi Na Lee ),정혁상 ( Hyuk Sang Jung ) 한방재활의학과학회 2014 한방재활의학과학회지 Vol.24 No.3
Objectives Osteoporosis is an impending problem in the rapidly aging society. The purpose of this study is to identify the effects of Yoohyangheukho-dan (Ruxiangheihu-dan) on osteoporosis induced by ovariectomy in rats. Methods 24 rats were randomly assigned to a SHAM group, a control group, and a Yoohyangheukho-dan (Ruxiangheihu-dan) group (n=8). Ovaries were extracted and for 8 weeks, the rats were given dry feeds and Yoohyangheukho-dan (Ruxiangheihu-dan) group were given a mixture of dry feeds and Yoohyangheukho-dan (Ruxiangheihu-dan). At 8 weeks, their body weight, femur mass, tibia ash per body ratio, overall surface area and thickness of the trabeculae, overall surface area of the osteoblasts, and the number of osteoclasts were measured and levels of albumin, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total-cholesterol, calcium and estradiol were recorded. Results There was no significant difference in the weight of the femur and the tibia ash per body ratio. The Yoohyangheukho-dan (Ruxiangheihu-dan) group had significantly thicker trabeculae than the control group and showed a minimal increase of overall surface area of the trabeculae. The overall surface area of the osteoblasts and the number of osteoclasts decreased in the Yoohyangheukho-dan (Ruxiangheihu-dan) group. There were no statistically significant differences in AST, ALT, ALP, total cholesterol, phosphorus, and estradiol levels. On the contrary the Yoohyangheukho-dan (Ruxiangheihu-dan) group had significantly higher levels of Albumin, triglyceride, and calcium. Conclusions It can be concluded that oral intake of Yoohyangheukho-dan (Ruxiangheihu- dan) prevents the thinning process of the trabeculae. Thus, it may have positive effects on the treatment and prevention of osteoporosis in postmenopausal women. (J Korean Med Rehab 2014;24(3):29-37)
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