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손진선,최배영 국제차문화학회 2023 차문화ㆍ산업학 Vol.62 No.-
The purpose of this study is to figure out the tea life behavior patterns of MZ generation women and to identify the relationship between tea life and wellness. For this purpose, an in-depth interview was conducted with 10 women in their 20s and 30s who have experienced tea life for more than 6 months, and the data were analyzed according to the MEASC model. The results of this study can be summarized as follows: First, the motivation of MZ generation women's tea life was induced for the health of mind and body, through the recommendation of family, or through education at university. Second, the exploration of tea life information consisted of various channels such as online (e.g., YouTube/Instagram/blog), offline (e.g., acquaintance recommendation/club activity/reading/pop-up store/expo visit), and online/offline (e.g., SNS and pop-up store). Third, tea drinking action was not only practiced by individuals at home or at work, but also with family members and school club members. In addition, communal drinking among MZ generation women naturally led to the sharing of tea drinking experiences. Fourth, MZ generation women confirmed the wellness that tea life brings to them and provided self-feedback.
Jinseon Son(손진선),Jinhee Choi(최진희) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5
An adverse outcome pathway (AOP) is a framework that organizes the predictive relationships between molecular initiating events (MIEs), key events (KEs), and adverse outcomes (AOs), which contributes to providing evidence based mechanistic insights. Meanwhile, integrating and utilizing the massive and heterogeneous data from different biological levels is a laborious and time intensive process, brings a challenge in AOP’s construction. Fortunately, mining available publicly database through computational and bioinformatics approaches can make the mass of biological information into better serve as the basis for creating expert-derived AOPs in a much more efficient way. The Comparative Toxicogenomics Database (CTD, http://ctdbase.org/), as a comprehensive, continuously updated and publicly available database, provides manually curated associations between and among chemicals, genes, phenotypes, diseases captured from the scientific literatures. The chemical-phenotype module of CTD provides numerous opportunities for users to unravel the complex interaction between environmental exposure and molecular and functional changes in organisms. As a part of OECD AOP program, the AOP Wiki (http://aopkb.org) serves as the primary repository of qualitative information for the international AOP development effort, provides insights to identify the upstream or downstream of KEs. We present a case study discerning the role of silver nanoparticles (AgNPs) in influencing phenotypes preceding infertility, a disease related to reproductive toxicity. Combining CTD’s phenotype-disease inference data, AgNPs-phenotypes were anchored to infertility. Through integrating analysis in AOP wiki knowledge base, filtered phenotypes were linked to key events consisting of AOPs and assembled together based on upstream and downstream relationships. A subset of 13 phenotypes were filtered from CTD as potential key events. Selected phenotypes were used to construct a predictive AOP connecting AgNPs to infertility. Independent MIEs represent a curated interaction between AgNPs and 11 genes are directly annotated to infertility from CTD’s disease core. This study will help address the existing knowledge gaps for future experimental verification. Furthermore, this study will help discover and connect information to expand the predictive AOPs, as well as interrelate other AOPs to generate hypotheses about chemical exposures and environmentally influenced disease.
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한솔아,손진선,김형태,김시인,서혜선 한국보건의료기술평가학회 2018 보건의료기술평가 Vol.6 No.1
Objectives: To evaluate the risk of infections by long-term oral corticosteroid use in elderly patients with severe asthma. Methods: This is a retrospective cohort study using nationally representative data, namely Health Insurance Review and Assessment Service-Aged Patient Sample 2015, that included medical and pharmacy claims of approximately 1 million elderly patients aged 65 or older. We included severe asthma patients who were classified as step 5 of Global Initiative for Asthma (GINA) guideline. Multivariate logistic regression was performed to compare incidence of infection in severe asthma patients continuously exposed ≥3 months oral corticosteroids (OCS) with severe asthma patients who continuously exposed ≥3 months tiotropium. Results: A total of 45 patients in OCS group and 107 patients in tiotropium group were identified. The odds of developing associated any infections were slightly higher but not significant in OCS group compared to those in tiotropium group; odds ratio (OR)=1.50, 95% confidence interval (CI)=0.67−3.36. In sub-group analysis, the odds of developing pneumonia were slightly lower (OR=0.78, 95% CI=0.30−2.00) and developing fungal infection were higher (OR=2.30, 95% CI=0.89−6.00) in OCS group compared to tiotropium group but both were not significant. Conclusion: Infections are known as oral corticosteroid related complication. However, the results of relationship between OCS use and incidence of infection were not significant. Further studies are warranted to evaluate the incidence of oral corticosteroids related infection